PathMap Literature Based Discovery Engine

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Experiment #00000137

Organic solvent exposure as an environmental risk factor associated with multiple sclerosis pathogenesis.

Genetic susceptibility _gates_from_genetic_susceptibility Environmental exposures _gates_to_environmental_exposures _gates_from_environmental_exposures Solvents _gates_to_solvents _gates_from_solvents Incidence _gates_to_incidence
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Experiment #00000132

Discovery: Considering PubMed #41177462, intranasal S-GEVs co-functionalized with ApoE peptides may bypass the cribriform plate and target astrocytic LRP1 receptors in order to suppress NF-κB and may resolve some neuroinflammation in Alzheimer's and ALS.

Administration, Intranasal _gates_from_administration__intranasal Blood-Brain Barrier _gates_to_blood_brain_barrier Apolipoproteins E _gates_from_apolipoproteins_e Low Density Lipoprotein Receptor-Related Protein-1 _gates_to_low_density_lipoprotein_receptor_related_protein_1 Signal Transduction _gates_from_signal_transduction
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Experiment #00000130

Targeted alteration of the oral microbiome via a single polyphenol- and fiber-dense meal plan creates an immediate shift in the microbial composition of involuntary nocturnal microaspiration droplets. Upon entry into the lower respiratory tract, this eubiotic bacterial influx acts as an acute molecular signal that rapidly modulates microglia reactivity and neuroinflammation via the lung-brain axis, bypassing systemic colonic metabolite transport.

Dietary modification _gates_from_dietary_modification Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Respiratory Aspiration _gates_to_respiratory_aspiration _gates_from_respiratory_aspiration Microglia _gates_to_microglia
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Experiment #00000129

COPD Dietary Idea: According to PubMed literature, he following lunchtime meal plan provides nutrients needed for production and regulation of tryptophan and 3-IPA and may help reduce COPD flare-ups, while also providing mucosal support for clearance of debris from the lungs: -2x slices sourdough bread, lightly spread with extra virgin olive oil, garlic, and ginger, with 2x slices of cooked turkey and spinach, with nutritional yeast and hi-maize corn starch mixed into the EVOO (for mucosal system support) -a spinach-based salad with 1 Tbsp EVOO -3 oz pomegranate juice mixed with 3 oz cherry juice

Tryptophan _gates_from_tryptophan Gut Microbiota _gates_to_gut_microbiota _gates_from_gut_microbiota Indolepropionic Acid _gates_to_indolepropionic_acid IPA _gates_from_ipa Lung
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Experiment #00000119

Hypothesis: Considering PubMed #41177462, Intranasally administered GDEVs, specifically spermidine-modified ginger extracellular vesicles, may offer a multi-target therapeutic strategy for C9orf72-associated ALS by crossing the blood-brain barrier via olfactory routes to potentially deliver gene-editing components, support axonal translation, restore STMN2 expression, and attenuate neuroinflammation.

Spermidine _gates_from_spermidine Olfactory Bulb _gates_to_olfactory_bulb Drug Delivery Systems _gates_from_drug_delivery_systems Stathmin 2 _gates_to_stathmin_2 Eukaryotic Initiation Factor-5A _gates_from_eukaryotic_initiation_factor_5a
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Experiment #00000112

Exploration of fermentation of plant roots used as a gut-brain axis mediator to reduce microglia activation and inflammation.

Plant Roots _gates_from_plant_roots Fermentation _gates_to_fermentation _gates_from_fermentation Gut-Brain Axis _gates_to_gut_brain_axis _gates_from_gut_brain_axis Microglia _gates_to_microglia
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Experiment #00000109

Clinically prescribed periodic "fasting" (caloric restriction), combined with dietary modification to include Omega-3 polyunsaturated fatty acids from fish and monounsaturated fats from olive oil, dietary fibers, and polyphenols from rich plant compounds may lower or balance toxic accumulated ceramides (like C16:0) via inhibition and metabolic processing in order to reduce organ aging and improve Circadian Efferocytosis Oscillation.

Caloric Restriction _gates_from_caloric_restriction Ceramides _gates_to_ceramides _gates_from_ceramides Insulin Resistance _gates_to_insulin_resistance Efferocytosis _gates_from_efferocytosis Inflammation
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Experiment #00000107

Restored Clearance of Senescent Neutrophils: Suggested Studies for Limiting Organ Aging

Neutrophils _gates_from_neutrophils Chronic Inflammation (Inflammaging) _gates_to_chronic_inflammation__inflammaging_ Chronic Inflammation _gates_from_chronic_inflammation Efferocytosis _gates_to_efferocytosis Pharmacological Phenomena _gates_from_pharmacological_phenomena
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Experiment #00000100

Hypothesis: Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging

Aging _gates_from_aging Phagocytosis _gates_to_phagocytosis _gates_from_phagocytosis Neutrophils _gates_to_neutrophils _gates_from_neutrophils _gates_to_aging Indoleacetic Acids
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Experiment #00000094

Hypothesis: If studied by scientists, pickled ginseng may be found to have therapeutic use in treating gut dysbiosis, potentially acting as a pathway to reduce neuroinflammation in some neurodegenerative diseases such as ALS.

Ginseng _gates_from_ginseng Gut Microbiota _gates_to_gut_microbiota _gates_from_gut_microbiota Neuroinflammation _gates_to_neuroinflammation _gates_from_neuroinflammation Neurodegenerative Diseases _gates_to_neurodegenerative_diseases
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Experiment #00000093

What is the core mechanism that Almased uses to improve metabolism and liver function and can the mechanism be repurposed as a therapeutic in neurodegenerative disease via the gut-brain axis?

Dietary Therapy _gates_from_dietary_therapy Intestinal Mucosa _gates_to_intestinal_mucosa _gates_from_intestinal_mucosa Inflammation Mediators _gates_to_inflammation_mediators Pro-inflammatory mediators _gates_from_pro_inflammatory_mediators Gastrointestinal Microbiome
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Experiment #00000082

Microbiota-derived acetate can alleviate neurological inflammation and neurodegeneration induced by hypoxia via the upregulation of brain-derived neurotrophic factor (BDNF).

Hypoxia _gates_from_hypoxia Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Acetic Acid _gates_to_acetic_acid _gates_from_acetic_acid Neuroinflammation _gates_to_neuroinflammation
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Experiment #00000081

How does the gut microbiome modulate inflammation?

Microbial Dysbiosis _gates_from_microbial_dysbiosis Permeability _gates_to_permeability _gates_from_permeability Bacterial Translocation _gates_to_bacterial_translocation _gates_from_bacterial_translocation Toll-Like Receptor 4 _gates_to_toll_like_receptor_4
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Experiment #00000078

Activated STING triggers inflammatory cytokines that directly drive astrocytic AQP4 depolarization; dampening this pathway restores the perivascular endfoot morphology necessary for glymphatic flow.

Metabolic Stress _gates_from_metabolic_stress DNA, Mitochondrial _gates_to_dna__mitochondrial _gates_from_dna__mitochondrial cGAS-STING Pathway _gates_to_cgas_sting_pathway _gates_from_cgas_sting_pathway Neuroinflammation _gates_to_neuroinflammation
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Experiment #00000074

OGT (O-GlcNAc transferase) modulation via pharmacological agonists can prevent degeneration of cranial nerves following traumatic or surgical stress.

Trauma/Stress _gates_from_trauma_stress Ferritinophagy/Oxidative Stress _gates_to_ferritinophagy_oxidative_stress Autophagy _gates_from_autophagy N-Acetylglucosaminyltransferases _gates_to_n_acetylglucosaminyltransferases _gates_from_n_acetylglucosaminyltransferases Neuronal Survival
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Experiment #00000064

Lon Protease, Alternaria; IL-33; TSLP; alarmins; asthma; chronic rhinosinusitis; fungal allergen; innate lymphoid cells

Alternaria _gates_from_alternaria Alarmins _gates_to_alarmins _gates_from_alarmins Immunity, Innate _gates_to_immunity__innate _gates_from_immunity__innate Lon-Peptidase _gates_to_lon_peptidase
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Experiment #00000054

What dietary habits are beneficial towards reducing excess/harmful tyramine in order to improve liver and gut health?

Dietary Proteins _gates_from_dietary_proteins Aromatic-L-Amino-Acid Decarboxylases _gates_to_aromatic_l_amino_acid_decarboxylases _gates_from_aromatic_l_amino_acid_decarboxylases Tyramine _gates_to_tyramine _gates_from_tyramine Gastrointestinal Diseases _gates_to_gastrointestinal_diseases
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Experiment #00000047

Does blast-induced mild traumatic brain injury (mTBI) drive progressive tau/TDP-43 seeding by disrupting astrocytic AQP4 glymphatic clearance and activating microglial cGAS-STING neuroinflammation? #mTBI #Glymphatic #cGASSTING

Blast Injuries _gates_from_blast_injuries Aquaporin 4 _gates_to_aquaporin_4 _gates_from_aquaporin_4 Glymphatic System _gates_to_glymphatic_system _gates_from_glymphatic_system Protein Aggregates _gates_to_protein_aggregates
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Experiment #00000042

#PITRM1 #ALS #Microglia #Mitochondria

PITRM1 protein, human _gates_from_pitrm1_protein__human Unfolded Protein Response _gates_to_unfolded_protein_response Mitochondrial Stress _gates_from_mitochondrial_stress DNA, Mitochondrial _gates_to_dna__mitochondrial _gates_from_dna__mitochondrial Neuroinflammation
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Experiment #00000041

What is the biological/molecular pathway that causes sarcopenia with the scope of COPD? Do the quads serve as a pathological progression indicator?

Pulmonary Disease, Chronic Obstructive _gates_from_pulmonary_disease__chronic_obstructive Systemic Inflammatory Response Syndrome _gates_to_systemic_inflammatory_response_syndrome _gates_from_systemic_inflammatory_response_syndrome Signal Transduction _gates_to_signal_transduction _gates_from_signal_transduction Muscular Atrophy _gates_to_muscular_atrophy
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Experiment #00000040

Can inhaled COVID-19 vaccinations be used to help treat COPD?

Pulmonary Disease, Chronic Obstructive _gates_from_pulmonary_disease__chronic_obstructive Administration, Inhalation _gates_to_administration__inhalation _gates_from_administration__inhalation Immunity, Mucosal _gates_to_immunity__mucosal Mucous Membrane _gates_to_mucous_membrane _gates_from_mucous_membrane
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Experiment #00000028

Are there any vitamins or supplements that have either old or recent clinical trial evidence of being beneficial for preventing or reducing migraines that may have been overlooked? I cannot afford the current migraine medications.

Dietary Factors _gates_from_dietary_factors Mitochondrial Dysfunction _gates_to_mitochondrial_dysfunction _gates_from_mitochondrial_dysfunction Hyperacusis _gates_to_hyperacusis Neurogenic Inflammation _gates_from_neurogenic_inflammation Dietary Supplements
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Experiment #00000027

How does eating legumes and vegetables help restore gut-brain axis homeostasis?

Vegetables _gates_from_vegetables Gastrointestinal Microbiome _gates_to_gastrointestinal_microbiome _gates_from_gastrointestinal_microbiome Inflammation _gates_to_inflammation _gates_from_inflammation Neuroprotection _gates_to_neuroprotection
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Experiment #00000020

Does age-related gut dysbiosis drive sarcopenia by activating the cGAS-STING inflammatory pathway to suppress satellite cell renewal?

Gastrointestinal Microbiome _gates_from_gastrointestinal_microbiome Inflammation _gates_to_inflammation _gates_from_inflammation cGAS-STING Pathway Activation _gates_to_cgas_sting_pathway_activation _gates_from_cgas_sting_pathway_activation Satellite Cells _gates_to_satellite_cells
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Experiment #00000017

How does the gut-brain axis play a role in Alzheimer's Disease? Is there a potential link for gut-brain axis for other neurological disorders such as Amyotrophic Lateral Sclerosis?

Dysbiosis _gates_from_dysbiosis Intestinal Permeability _gates_to_intestinal_permeability _gates_from_intestinal_permeability Systemic Inflammatory Response Syndrome _gates_to_systemic_inflammatory_response_syndrome _gates_from_systemic_inflammatory_response_syndrome Neuroinflammation _gates_to_neuroinflammation
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Experiment #00000011

Do persistent viral reservoirs or latent viral reactivations trigger mitochondrial dysfunction and promote long-term T-cell exhaustion in patients with severe post-exertional malaise

Virus Latency _gates_from_virus_latency Antigen persistence _gates_to_antigen_persistence _gates_from_antigen_persistence Reactive Oxygen Species _gates_to_reactive_oxygen_species _gates_from_reactive_oxygen_species T-Cell Exhaustion _gates_to_t_cell_exhaustion
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Experiment #00000004

Can the identified lysosomal-targeted acidic nanoparticles (AcNPs) or specific small-molecule chaperones effectively reverse established alpha-synuclein aggregation in chronic exposure models, and do they provide neuroprotection against subsequent environmental pollutant insults?

Lysosomal Storage Diseases _gates_from_lysosomal_storage_diseases alpha-Synuclein _gates_to_alpha_synuclein Alpha-synuclein aggregation _gates_from_alpha_synuclein_aggregation Molecular Chaperones _gates_to_molecular_chaperones Lysosomes _gates_from_lysosomes
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Experiment #00000002

Does chronic latent Epstein-Barr Virus (EBV) reactivation drive microglial activation and subsequent myelin destruction in Multiple Sclerosis via the activation of the cGAS-STING innate immune pathway?

Epstein-Barr Virus Infections _gates_from_epstein_barr_virus_infections Microglial Activation _gates_to_microglial_activation _gates_from_microglial_activation cGAS-STING Signaling _gates_to_cgas_sting_signaling _gates_from_cgas_sting_signaling Demyelinating Diseases _gates_to_demyelinating_diseases
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