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Experiment #00000105
Gap Analysis: There is no PubMed data showing wet lab data or analysis of TPD-43 proteinopathy found (or not found) in the Cochlear, Spiral, or Scarpa's Ganglion of Amyotrophic Lateral Sclerosis patient data post mortem.
Amyotrophic Lateral Sclerosis
_gates_from_amyotrophic_lateral_sclerosis
TDP-43 proteinopathy
_gates_to_tdp_43_proteinopathy
_gates_from_tdp_43_proteinopathy
Spiral Ganglion
_gates_to_spiral_ganglion
Peripheral Nerves
_gates_from_peripheral_nerves
_gates_to_amyotrophic_lateral_sclerosis
Noise-Induced Hearing Loss
_gates_from_noise_induced_hearing_loss
DNA-Binding Proteins
_gates_to_dna_binding_proteins
_gates_from_dna_binding_proteins
Autophagy
_gates_to_autophagy
_gates_from_autophagy
Hearing Disorders
_gates_to_hearing_disorders
+10 more
View Results
Experiment #00000074
OGT (O-GlcNAc transferase) modulation via pharmacological agonists can prevent degeneration of cranial nerves following traumatic or surgical stress.
Trauma/Stress
_gates_from_trauma_stress
Ferritinophagy/Oxidative Stress
_gates_to_ferritinophagy_oxidative_stress
Autophagy
_gates_from_autophagy
N-Acetylglucosaminyltransferases
_gates_to_n_acetylglucosaminyltransferases
_gates_from_n_acetylglucosaminyltransferases
Neuronal Survival
_gates_to_neuronal_survival
Stress, Physiological
_gates_from_stress__physiological
Neuroinflammation
_gates_to_neuroinflammation
_gates_from_neuroinflammation
Acetylglucosamine
_gates_to_acetylglucosamine
_gates_from_acetylglucosamine
Neuronal Death
_gates_to_neuronal_death
Enzyme Inhibitors
_gates_from_enzyme_inhibitors
Glycosylation
_gates_to_glycosylation
_gates_from_glycosylation
Nerve Tissue Proteins
_gates_to_nerve_tissue_proteins
_gates_from_nerve_tissue_proteins
Neurodegenerative Diseases
_gates_to_neurodegenerative_diseases
+21 more
View Results
Experiment #00000073
Can botulinum toxin A (BTX-A) be repurposed from cosmetic/spasticity applications in order to treat oculomotor palsy and have utilization with endoscopic endonasal approaches to skull base tumors to protect cranial nerves?
Botulinum Toxins, Type A
_gates_from_botulinum_toxins__type_a
Muscle Relaxation
_gates_to_muscle_relaxation
_gates_from_muscle_relaxation
Neuroprotection
_gates_to_neuroprotection
Oculomotor Nerve Diseases
_gates_from_oculomotor_nerve_diseases
BTX-A
_gates_to_btx_a
_gates_from_btx_a
Surgery
_gates_to_surgery
Natural Orifice Endoscopic Surgery
_gates_from_natural_orifice_endoscopic_surgery
Multimodal Neuromonitoring
_gates_to_multimodal_neuromonitoring
Skull Base Neoplasms
_gates_from_skull_base_neoplasms
Neuromonitoring (not BTX-A)
_gates_to_neuromonitoring__not_btx_a_
_gates_to_botulinum_toxins__type_a
Contracture
_gates_to_contracture
Skull Base
_gates_from_skull_base
_gates_to_natural_orifice_endoscopic_surgery
+18 more
View Results
Experiment #00000038
Map the direct mechanical and axonal transport pathways connecting intranasal administration or trigeminal nerve delivery to the clearance of TDP-43 aggregates in sporadic ALS, and the delivery of CRISPR-Cas/ASO gene therapies targeting C9orf72 hexanucleotide repeat expansions in the cerebellum and brainstem.
Intranasal Route
_gates_from_intranasal_route
Blood-Brain Barrier
_gates_to_blood_brain_barrier
C9orf72 Protein
_gates_to_c9orf72_protein
_gates_from_c9orf72_protein
Brain
_gates_to_brain
Intranasal Administration
_gates_from_intranasal_administration
Cranial Nerves
_gates_to_cranial_nerves
_gates_from_cranial_nerves
Biological Transport
_gates_to_biological_transport
_gates_from_brain
Drug Delivery Systems
_gates_from_drug_delivery_systems
DNA-Binding Proteins
_gates_to_dna_binding_proteins
Neural Pathways
_gates_from_neural_pathways
Central Nervous System
_gates_to_central_nervous_system
+15 more
View Results
Reference Abstract
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Source: PubMed
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