PathMap Literature Based Discovery Engine

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Experiment #00000115

Ebola Virus Outbreak Solution Hypothesis: Oral ginger-derived extracellular vesicles may serve as an acid-stable, inexpensive, and supply-chain ready clinical solution to deliver 6-shogaol to macrophages, triggering CASA autophagy to degrade EBOV VP40 and halt viral egress.

Ginger extract _gates_from_ginger_extract Autophagy _gates_to_autophagy Autophagy (CASA) _gates_from_autophagy__casa_ Viral Matrix Proteins _gates_to_viral_matrix_proteins Proteolysis _gates_from_proteolysis

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Experiment #00000114

Biohack, Anti-Ebola Hypothesis 1: PDEV-to-macrophage siRNA targeting VP40 Load the plant vesicles with synthetic siRNAs designed to silence VP40 transcription directly inside the macrophage. Exploration of dietary, pharmacological, and repurposed solutions to achieve this.

PDEV isolation _gates_from_pdev_isolation RNA, Small Interfering _gates_to_rna__small_interfering _gates_from_rna__small_interfering Macrophage Activation _gates_to_macrophage_activation _gates_from_macrophage_activation Gene Silencing _gates_to_gene_silencing

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