Search Results for "immune system diseases"

Experiment #00000084

SOD1 Research July 2026

Genetic Testing _gates_from_genetic_testing Drug Delivery Systems _gates_to_drug_delivery_systems _gates_from_drug_delivery_systems Superoxide Dismutase-1 _gates_to_superoxide_dismutase_1 Protein Aggregates _gates_from_protein_aggregates Oxidative Stress

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Experiment #00000082

Microbiota-derived acetate can alleviate neurological inflammation and neurodegeneration induced by hypoxia via the upregulation of brain-derived neurotrophic factor (BDNF).

Hypoxia _gates_from_hypoxia Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Acetic Acid _gates_to_acetic_acid _gates_from_acetic_acid Neuroinflammation _gates_to_neuroinflammation

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Experiment #00000081

How does the gut microbiome modulate inflammation?

Microbial Dysbiosis _gates_from_microbial_dysbiosis Permeability _gates_to_permeability _gates_from_permeability Bacterial Translocation _gates_to_bacterial_translocation _gates_from_bacterial_translocation Toll-Like Receptor 4 _gates_to_toll_like_receptor_4

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Experiment #00000080

Prenatal iron deficiency (ID) exacerbates the risk of sudden infant death syndrome (SIDS) by modulating the expression of the hypothalamic orexin system, impairing homeostatic arousal mechanisms during hypoxia.

Anemia, Iron-Deficiency _gates_from_anemia__iron_deficiency Hypothalamic-Hypophyseal System _gates_to_hypothalamic_hypophyseal_system _gates_from_hypothalamic_hypophyseal_system Sudden Infant Death _gates_to_sudden_infant_death _gates_from_sudden_infant_death Orexins _gates_to_orexins

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Experiment #00000079

Why do seemingly perfectly healthy infants suddenly pass away in their sleep?

Infant, Newborn _gates_from_infant__newborn Autonomic Nervous System _gates_to_autonomic_nervous_system _gates_from_autonomic_nervous_system Death, Sudden _gates_to_death__sudden _gates_from_death__sudden Sudden Infant Death _gates_to_sudden_infant_death

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Experiment #00000078

Activated STING triggers inflammatory cytokines that directly drive astrocytic AQP4 depolarization; dampening this pathway restores the perivascular endfoot morphology necessary for glymphatic flow.

Metabolic Stress _gates_from_metabolic_stress DNA, Mitochondrial _gates_to_dna__mitochondrial _gates_from_dna__mitochondrial cGAS-STING Pathway _gates_to_cgas_sting_pathway _gates_from_cgas_sting_pathway Neuroinflammation _gates_to_neuroinflammation

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Experiment #00000075

Polystyrene nanoplastics (PS-NPs) may act as a scaffold for the recruitment and accumulation of WDR44 at the lysosomal membrane, thereby accelerating the de novo aggregation of alpha-synuclein in the early stages of PD.

Nanoplastic exposure _gates_from_nanoplastic_exposure Lysosomal Storage Diseases _gates_to_lysosomal_storage_diseases _gates_from_lysosomal_storage_diseases alpha-Synuclein _gates_to_alpha_synuclein WDR44 _gates_from_wdr44 Protein Aggregates

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Experiment #00000074

OGT (O-GlcNAc transferase) modulation via pharmacological agonists can prevent degeneration of cranial nerves following traumatic or surgical stress.

Trauma/Stress _gates_from_trauma_stress Ferritinophagy/Oxidative Stress _gates_to_ferritinophagy_oxidative_stress Autophagy _gates_from_autophagy N-Acetylglucosaminyltransferases _gates_to_n_acetylglucosaminyltransferases _gates_from_n_acetylglucosaminyltransferases Neuronal Survival

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Experiment #00000073

Can botulinum toxin A (BTX-A) be repurposed from cosmetic/spasticity applications in order to treat oculomotor palsy and have utilization with endoscopic endonasal approaches to skull base tumors to protect cranial nerves?

Botulinum Toxins, Type A _gates_from_botulinum_toxins__type_a Muscle Relaxation _gates_to_muscle_relaxation _gates_from_muscle_relaxation Neuroprotection _gates_to_neuroprotection Oculomotor Nerve Diseases _gates_from_oculomotor_nerve_diseases BTX-A

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Experiment #00000071

Do any recent non-proliferative diabetic retinopathy clinical trials reveal anything about Amyotrophic Lateral Sclerosis?

Diabetic Retinopathy _gates_from_diabetic_retinopathy ALS _gates_to_als Retinal Diseases _gates_to_retinal_diseases _gates_from_retinal_diseases Neurodegenerative Diseases _gates_to_neurodegenerative_diseases _gates_from_neurodegenerative_diseases

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Experiment #00000070

What types of infections might cause a high C-Reactive Protein result?

Pathogen presence _gates_from_pathogen_presence Immunity, Innate _gates_to_immunity__innate _gates_from_immunity__innate C-Reactive Protein _gates_to_c_reactive_protein _gates_from_c_reactive_protein Biomarkers _gates_to_biomarkers

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Experiment #00000066

Are there any wellness alternatives for Von Willebrand Disease?

von Willebrand Diseases _gates_from_von_willebrand_diseases Multidisciplinary Care _gates_to_multidisciplinary_care _gates_from_multidisciplinary_care Transcutaneous Electric Nerve Stimulation _gates_to_transcutaneous_electric_nerve_stimulation Electric Stimulation Therapy _gates_to_electric_stimulation_therapy _gates_from_electric_stimulation_therapy

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Experiment #00000065

Does pathologically seeded TDP-43 exit the retina via anterograde axonal transport along the optic tract to midbrain hubs, enter the systemic circulation inside extracellular vesicles, and subsequently traffic into pancreatic beta-cells to accelerate type 2 diabetes phenotypes?

TAR DNA-Binding Protein 43 _gates_from_tar_dna_binding_protein_43 Extracellular Vesicles _gates_to_extracellular_vesicles Systemic circulating EVs _gates_from_systemic_circulating_evs Insulin-Secreting Cells _gates_to_insulin_secreting_cells Axonal Transport _gates_to_axonal_transport

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Experiment #00000064

Lon Protease, Alternaria; IL-33; TSLP; alarmins; asthma; chronic rhinosinusitis; fungal allergen; innate lymphoid cells

Alternaria _gates_from_alternaria Alarmins _gates_to_alarmins _gates_from_alarmins Immunity, Innate _gates_to_immunity__innate _gates_from_immunity__innate Lon-Peptidase _gates_to_lon_peptidase

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Experiment #00000062

NESCO-induced pyroptosis in the peritoneal microenvironment might be attenuated by the upregulation of 11-oxygenated androgens in the systemic circulation.

Endometriosis _gates_from_endometriosis Tumor Microenvironment _gates_to_tumor_microenvironment Androgens _gates_from_androgens _gates_to_endometriosis Disease Models, Animal _gates_from_disease_models__animal NESCO and Androgens

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Experiment #00000057

Amyotrophic Lateral Sclerosis breakthrough updates as of July 2026

Systemic Disease _gates_from_systemic_disease Gene Expression Regulation _gates_to_gene_expression_regulation

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Experiment #00000056

Sarcopenia and Amyotrophic Lateral Sclerosis: Biological Pathways and Analysis

Motor Neuron Disease _gates_from_motor_neuron_disease Neuromuscular Junction Diseases _gates_to_neuromuscular_junction_diseases _gates_from_neuromuscular_junction_diseases Muscle Weakness _gates_to_muscle_weakness NMJ instability _gates_from_nmj_instability Sarcopenia

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Experiment #00000054

What dietary habits are beneficial towards reducing excess/harmful tyramine in order to improve liver and gut health?

Dietary Proteins _gates_from_dietary_proteins Aromatic-L-Amino-Acid Decarboxylases _gates_to_aromatic_l_amino_acid_decarboxylases _gates_from_aromatic_l_amino_acid_decarboxylases Tyramine _gates_to_tyramine _gates_from_tyramine Gastrointestinal Diseases _gates_to_gastrointestinal_diseases

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Experiment #00000048

The ALS-T2D comorbidity is driven by a bidirectional, exosome-mediated proteostatic collapse. Peripheral tissues (muscle, pancreas) dictate CNS TDP-43 stability via exosomal miRNAs (miR-126a-5p) and glucose-dependent modifications (O-GlcNAcylation). Conversely, pharmacological activation of ubiquitin-peptidases (e.g., Acarbose targeting USP46) or restitution of glycolytic cofactors (F2,6BP) represent novel, cross-disciplinary therapeutic targets capable of halting systemic proteinopathy.

Diabetes Mellitus, Type 2 _gates_from_diabetes_mellitus__type_2 Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles DNA-Binding Proteins _gates_to_dna_binding_proteins _gates_from_dna_binding_proteins Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis

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Experiment #00000047

Does blast-induced mild traumatic brain injury (mTBI) drive progressive tau/TDP-43 seeding by disrupting astrocytic AQP4 glymphatic clearance and activating microglial cGAS-STING neuroinflammation? #mTBI #Glymphatic #cGASSTING

Blast Injuries _gates_from_blast_injuries Aquaporin 4 _gates_to_aquaporin_4 _gates_from_aquaporin_4 Glymphatic System _gates_to_glymphatic_system _gates_from_glymphatic_system Protein Aggregates _gates_to_protein_aggregates

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Experiment #00000046

How does knitting help improve mental health?

Knitting _gates_from_knitting Psychophysiology _gates_to_psychophysiology _gates_from_psychophysiology Neurotransmitter Release _gates_to_neurotransmitter_release _gates_from_neurotransmitter_release Anxiety _gates_to_anxiety

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Experiment #00000041

What is the biological/molecular pathway that causes sarcopenia with the scope of COPD? Do the quads serve as a pathological progression indicator?

Pulmonary Disease, Chronic Obstructive _gates_from_pulmonary_disease__chronic_obstructive Systemic Inflammatory Response Syndrome _gates_to_systemic_inflammatory_response_syndrome _gates_from_systemic_inflammatory_response_syndrome Signal Transduction _gates_to_signal_transduction _gates_from_signal_transduction Muscular Atrophy _gates_to_muscular_atrophy

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Experiment #00000040

Can inhaled COVID-19 vaccinations be used to help treat COPD?

Pulmonary Disease, Chronic Obstructive _gates_from_pulmonary_disease__chronic_obstructive Administration, Inhalation _gates_to_administration__inhalation _gates_from_administration__inhalation Immunity, Mucosal _gates_to_immunity__mucosal Mucous Membrane _gates_to_mucous_membrane _gates_from_mucous_membrane

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Experiment #00000038

Map the direct mechanical and axonal transport pathways connecting intranasal administration or trigeminal nerve delivery to the clearance of TDP-43 aggregates in sporadic ALS, and the delivery of CRISPR-Cas/ASO gene therapies targeting C9orf72 hexanucleotide repeat expansions in the cerebellum and brainstem.

Intranasal Route _gates_from_intranasal_route Blood-Brain Barrier _gates_to_blood_brain_barrier C9orf72 Protein _gates_to_c9orf72_protein _gates_from_c9orf72_protein Brain _gates_to_brain Intranasal Administration

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Experiment #00000031

Why are frontotemporal dementia and c9orf72 ALS considered different diseases if they are both driven by the same abnormal expansion of a GGGGCC (G₄C₂) sequence in the first intron of the C9orf72 gene? Is it logical to think that CRISPR therapeutics for FTD potentially be used for ALS as well?

C9orf72 expansion _gates_from_c9orf72_expansion Gene Expression Regulation _gates_to_gene_expression_regulation _gates_from_gene_expression_regulation Protein Aggregation, Pathological _gates_to_protein_aggregation__pathological _gates_from_protein_aggregation__pathological CRISPR-Cas Systems _gates_to_crispr_cas_systems

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Experiment #00000030

Can AI and single-cell RNA sequencing help map cryptic TDP-43 splicing errors in sporadic ALS to design BBB-penetrant CRISPR gene therapies before neurotoxicity begins?

Single-Cell Analysis _gates_from_single_cell_analysis RNA Splicing _gates_to_rna_splicing _gates_from_rna_splicing Blood-Brain Barrier _gates_to_blood_brain_barrier _gates_from_blood_brain_barrier Neurotoxicity Syndromes _gates_to_neurotoxicity_syndromes

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Experiment #00000029

Why do people get tinnitus and are there any wellness alternatives to help reduce the impact it has on lifestyle and comfort?

Cochlear Diseases _gates_from_cochlear_diseases Neuronal Plasticity _gates_to_neuronal_plasticity _gates_from_neuronal_plasticity Tinnitus _gates_to_tinnitus _gates_from_tinnitus Health Promotion _gates_to_health_promotion

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Experiment #00000025

How does sarcopenia feel versus Amyotrophic Lateral Sclerosis fasciculations or age-related proximal myopathy?

Sarcopenia _gates_from_sarcopenia Clinical Symptomatology _gates_to_clinical_symptomatology Muscular Atrophy _gates_to_muscular_atrophy ALS _gates_from_als Neuromuscular Diseases _gates_to_neuromuscular_diseases

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Experiment #00000018

Can smoking cigarettes cause dysbiosis?

Tobacco Smoke Pollution _gates_from_tobacco_smoke_pollution Epithelium _gates_to_epithelium _gates_from_epithelium Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Immune System Diseases _gates_to_immune_system_diseases

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Experiment #00000017

How does the gut-brain axis play a role in Alzheimer's Disease? Is there a potential link for gut-brain axis for other neurological disorders such as Amyotrophic Lateral Sclerosis?

Dysbiosis _gates_from_dysbiosis Intestinal Permeability _gates_to_intestinal_permeability _gates_from_intestinal_permeability Systemic Inflammatory Response Syndrome _gates_to_systemic_inflammatory_response_syndrome _gates_from_systemic_inflammatory_response_syndrome Neuroinflammation _gates_to_neuroinflammation

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Experiment #00000014

Under certain conditions, can hyperexcited retinal ganglion cells misfire corollary discharge(s) unexpectedly?

Oculomotor Motor Command _gates_from_oculomotor_motor_command Corollary Discharge _gates_to_corollary_discharge _gates_from_corollary_discharge Sensory Processing, Sensory _gates_to_sensory_processing__sensory Retinal Ganglion Cells (RGCs) _gates_from_retinal_ganglion_cells__rgcs_ Visual Perception

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Experiment #00000012

If a toxin with a thermodynamic affinity for Zinc GREATER THAN that of Glutamate AND LESS THAN that of RGNEF, under certain conditions a pathway exists wherein the toxin could shuttle synaptic retinal zinc to RGNEF, thus potentially ultimately resulting in the retinal TDP-43 proteinopathy seen in the retina post mortem in Sporadic Amyotrophic Lateral Sclerosis

Synaptic Zinc _gates_from_synaptic_zinc Receptors, Glutamate _gates_to_receptors__glutamate _gates_from_receptors__glutamate Zinc Dyshomeostasis in RGCs _gates_to_zinc_dyshomeostasis_in_rgcs _gates_from_zinc_dyshomeostasis_in_rgcs TDP-43 Proteinopathy _gates_to_tdp_43_proteinopathy

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Experiment #00000011

Do persistent viral reservoirs or latent viral reactivations trigger mitochondrial dysfunction and promote long-term T-cell exhaustion in patients with severe post-exertional malaise

Virus Latency _gates_from_virus_latency Antigen persistence _gates_to_antigen_persistence _gates_from_antigen_persistence Reactive Oxygen Species _gates_to_reactive_oxygen_species _gates_from_reactive_oxygen_species T-Cell Exhaustion _gates_to_t_cell_exhaustion

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Guaranteed to find unpublished literature based discoveries.

SOD1 Research July 2026

Microbiota-derived acetate can alleviate neurological inflammation and neurodegeneration induced by hypoxia via the upregulation of brain-derived neurotrophic factor (BDNF).

How does the gut microbiome modulate inflammation?

Prenatal iron deficiency (ID) exacerbates the risk of sudden infant death syndrome (SIDS) by modulating the expression of the hypothalamic orexin system, impairing homeostatic arousal mechanisms during hypoxia.

Why do seemingly perfectly healthy infants suddenly pass away in their sleep?

Activated STING triggers inflammatory cytokines that directly drive astrocytic AQP4 depolarization; dampening this pathway restores the perivascular endfoot morphology necessary for glymphatic flow.

Polystyrene nanoplastics (PS-NPs) may act as a scaffold for the recruitment and accumulation of WDR44 at the lysosomal membrane, thereby accelerating the de novo aggregation of alpha-synuclein in the early stages of PD.

OGT (O-GlcNAc transferase) modulation via pharmacological agonists can prevent degeneration of cranial nerves following traumatic or surgical stress.

Can botulinum toxin A (BTX-A) be repurposed from cosmetic/spasticity applications in order to treat oculomotor palsy and have utilization with endoscopic endonasal approaches to skull base tumors to protect cranial nerves?

Do any recent non-proliferative diabetic retinopathy clinical trials reveal anything about Amyotrophic Lateral Sclerosis?

What types of infections might cause a high C-Reactive Protein result?

Are there any wellness alternatives for Von Willebrand Disease?

Does pathologically seeded TDP-43 exit the retina via anterograde axonal transport along the optic tract to midbrain hubs, enter the systemic circulation inside extracellular vesicles, and subsequently traffic into pancreatic beta-cells to accelerate type 2 diabetes phenotypes?

Lon Protease, Alternaria; IL-33; TSLP; alarmins; asthma; chronic rhinosinusitis; fungal allergen; innate lymphoid cells

NESCO-induced pyroptosis in the peritoneal microenvironment might be attenuated by the upregulation of 11-oxygenated androgens in the systemic circulation.

Amyotrophic Lateral Sclerosis breakthrough updates as of July 2026

Sarcopenia and Amyotrophic Lateral Sclerosis: Biological Pathways and Analysis

What dietary habits are beneficial towards reducing excess/harmful tyramine in order to improve liver and gut health?

Does blast-induced mild traumatic brain injury (mTBI) drive progressive tau/TDP-43 seeding by disrupting astrocytic AQP4 glymphatic clearance and activating microglial cGAS-STING neuroinflammation? #mTBI #Glymphatic #cGASSTING

How does knitting help improve mental health?

What is the biological/molecular pathway that causes sarcopenia with the scope of COPD? Do the quads serve as a pathological progression indicator?

Can inhaled COVID-19 vaccinations be used to help treat COPD?

Why are frontotemporal dementia and c9orf72 ALS considered different diseases if they are both driven by the same abnormal expansion of a GGGGCC (G₄C₂) sequence in the first intron of the C9orf72 gene? Is it logical to think that CRISPR therapeutics for FTD potentially be used for ALS as well?

Can AI and single-cell RNA sequencing help map cryptic TDP-43 splicing errors in sporadic ALS to design BBB-penetrant CRISPR gene therapies before neurotoxicity begins?

Why do people get tinnitus and are there any wellness alternatives to help reduce the impact it has on lifestyle and comfort?

How does sarcopenia feel versus Amyotrophic Lateral Sclerosis fasciculations or age-related proximal myopathy?

Can smoking cigarettes cause dysbiosis?

How does the gut-brain axis play a role in Alzheimer's Disease? Is there a potential link for gut-brain axis for other neurological disorders such as Amyotrophic Lateral Sclerosis?

Under certain conditions, can hyperexcited retinal ganglion cells misfire corollary discharge(s) unexpectedly?

Do persistent viral reservoirs or latent viral reactivations trigger mitochondrial dysfunction and promote long-term T-cell exhaustion in patients with severe post-exertional malaise

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