PathMap Literature Based Discovery Engine
Share your Discovery:
Guaranteed to find unpublished literature based discoveries.
SOD1 Research July 2026


How does the gut microbiome modulate inflammation?


Why do seemingly perfectly healthy infants suddenly pass away in their sleep?


What types of infections might cause a high C-Reactive Protein result?


Amyotrophic Lateral Sclerosis breakthrough updates as of July 2026


The ALS-T2D comorbidity is driven by a bidirectional, exosome-mediated proteostatic collapse. Peripheral tissues (muscle, pancreas) dictate CNS TDP-43 stability via exosomal miRNAs (miR-126a-5p) and glucose-dependent modifications (O-GlcNAcylation). Conversely, pharmacological activation of ubiquitin-peptidases (e.g., Acarbose targeting USP46) or restitution of glycolytic cofactors (F2,6BP) represent novel, cross-disciplinary therapeutic targets capable of halting systemic proteinopathy.


Diabetes Mellitus, Type 2
_gates_from_diabetes_mellitus__type_2
Extracellular Vesicles
_gates_to_extracellular_vesicles
_gates_from_extracellular_vesicles
DNA-Binding Proteins
_gates_to_dna_binding_proteins
_gates_from_dna_binding_proteins
Amyotrophic Lateral Sclerosis
_gates_to_amyotrophic_lateral_sclerosis
How does knitting help improve mental health?


What is the biological/molecular pathway that causes sarcopenia with the scope of COPD? Do the quads serve as a pathological progression indicator?


Pulmonary Disease, Chronic Obstructive
_gates_from_pulmonary_disease__chronic_obstructive
Systemic Inflammatory Response Syndrome
_gates_to_systemic_inflammatory_response_syndrome
_gates_from_systemic_inflammatory_response_syndrome
Signal Transduction
_gates_to_signal_transduction
_gates_from_signal_transduction
Muscular Atrophy
_gates_to_muscular_atrophy
Can inhaled COVID-19 vaccinations be used to help treat COPD?


Pulmonary Disease, Chronic Obstructive
_gates_from_pulmonary_disease__chronic_obstructive
Administration, Inhalation
_gates_to_administration__inhalation
_gates_from_administration__inhalation
Immunity, Mucosal
_gates_to_immunity__mucosal
Mucous Membrane
_gates_to_mucous_membrane
_gates_from_mucous_membrane
Why are frontotemporal dementia and c9orf72 ALS considered different diseases if they are both driven by the same abnormal expansion of a GGGGCC (G₄C₂) sequence in the first intron of the C9orf72 gene? Is it logical to think that CRISPR therapeutics for FTD potentially be used for ALS as well?


C9orf72 expansion
_gates_from_c9orf72_expansion
Gene Expression Regulation
_gates_to_gene_expression_regulation
_gates_from_gene_expression_regulation
Protein Aggregation, Pathological
_gates_to_protein_aggregation__pathological
_gates_from_protein_aggregation__pathological
CRISPR-Cas Systems
_gates_to_crispr_cas_systems
Can smoking cigarettes cause dysbiosis?


How does the gut-brain axis play a role in Alzheimer's Disease? Is there a potential link for gut-brain axis for other neurological disorders such as Amyotrophic Lateral Sclerosis?


Dysbiosis
_gates_from_dysbiosis
Intestinal Permeability
_gates_to_intestinal_permeability
_gates_from_intestinal_permeability
Systemic Inflammatory Response Syndrome
_gates_to_systemic_inflammatory_response_syndrome
_gates_from_systemic_inflammatory_response_syndrome
Neuroinflammation
_gates_to_neuroinflammation
Does chronic latent Epstein-Barr Virus (EBV) reactivation drive microglial activation and subsequent myelin destruction in Multiple Sclerosis via the activation of the cGAS-STING innate immune pathway?


Epstein-Barr Virus Infections
_gates_from_epstein_barr_virus_infections
Microglial Activation
_gates_to_microglial_activation
_gates_from_microglial_activation
cGAS-STING Signaling
_gates_to_cgas_sting_signaling
_gates_from_cgas_sting_signaling
Demyelinating Diseases
_gates_to_demyelinating_diseases
Need a custom Literature-Based Discovery?
Get 1-3 unpublished, new, novel, real and non-implausible literature based discoveries with each order of a PathMap Evaluation (3x) package.
Order a custom PathMap Evaluation (3x) - $29.99








