PathMap Literature Based Discovery Engine

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Experiment #00000141

Hypothesis: Repurposing IVF screening tools to verify CRISPR-corrected induced pluripotent stem cells (iPSCs), combined with in vitro gametogenesis, may potentially create disease-free germlines that could eradicate heritable hematological mutations in future generations, such as sickle cell disease.

CRISPR-Cas Systems _gates_from_crispr_cas_systems Induced Pluripotent Stem Cells _gates_to_induced_pluripotent_stem_cells _gates_from_induced_pluripotent_stem_cells Anemia, Sickle Cell _gates_to_anemia__sickle_cell
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Experiment #00000139

Foundational Dietary Theory: The dietary synergy between Hi-Maize and 6x Spermidine Yeast creates a potential cellular supply-and-clearance loop within the brain's astrocytes. Circulating spermidine metabolites utilize documented astrocytic polyamine uptake systems to access the central nervous system. Once inside, this exogenous spermidine drives FAM134B-mediated ER-phagy, clearing the endoplasmic reticulum matrix. This clearance removes the ER-stress bottleneck, allowing newly transcribed astrocytic EAAT2—upregulated by gut-derived butyrate from Hi-Maize fermentation—to successfully traffic to the plasma membrane and mitigate synaptic glutamate excitotoxicity.

Starch, Resistant _gates_from_starch__resistant Butyric Acid _gates_to_butyric_acid _gates_from_butyric_acid Glutamate Plasma Membrane Transport Proteins _gates_to_glutamate_plasma_membrane_transport_proteins Spermidine _gates_from_spermidine Autophagy
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Experiment #00000136

Borneol-mediated membrane permeability can enhance the therapeutic delivery of plant-derived extracellular vesicles to deep-seated endometriotic lesions, bridging the gap between existing delivery enhancements for CNS ischemia and local anti-fibrotic treatments.

Borneol _gates_from_borneol Drug Delivery Systems _gates_to_drug_delivery_systems _gates_from_drug_delivery_systems Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles Fibrosis _gates_to_fibrosis
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Experiment #00000135

Discovery: Vaginal delivery of Hyaluronic Acid-modified Ginger Extracellular Vesicles (HA-GDEVs) co-functionalized with borneol may penetrate fibrotic endometriotic lesions via CD44 targeting, delivering anti-angiogenic payloads to induce lesion regression without systemic hormonal toxicity.

Extracellular Vesicles _gates_from_extracellular_vesicles Drug Delivery Systems _gates_to_drug_delivery_systems _gates_from_drug_delivery_systems Remission Induction _gates_to_remission_induction _gates_from_remission_induction Drug-Related Side Effects and Adverse Reactions _gates_to_drug_related_side_effects_and_adverse_reactions
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Experiment #00000134

Hypothesis: Intraperitoneal administration of a thermoresponsive hydrogel loaded with borneol-functionalized ginger derived extracellular vesicles (Moxibustion-Modified GDEVs) may provide a sustained, localized delivery to ovarian tumors, potentially enhancing deep tissue penetration and inducing apoptosis without systemic chemotoxicity.

Extracellular Vesicles _gates_from_extracellular_vesicles Nanocarriers _gates_to_nanocarriers Hydrogels _gates_to_hydrogels _gates_from_hydrogels Delayed-Action Preparations _gates_to_delayed_action_preparations Borneol/GEVs
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Experiment #00000131

Premise: Environmental metals, though present in many Amyotrophic Lateral Sclerosis anomalous clusters, are debated regarding causality within geographic epistemological data. Hypothesis: If plant derived extracellular vesicles (PDEVs) aerosolized with environmental metals, they could potentially bypass the blood brain barrier via the cribriform plate area. Given this potential method of delivery, environmental metals cannot be ruled out as causal in sporadic ALS until PDEV delivery of the metals is tested in wet lab experiments, but may potentially explain the confounding data.

Environmental Pollutants _gates_from_environmental_pollutants PDEV association _gates_to_pdev_association _gates_from_pdev_association Nose-to-Brain Delivery _gates_to_nose_to_brain_delivery _gates_from_nose_to_brain_delivery Brain Diseases _gates_to_brain_diseases
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Experiment #00000130

Targeted alteration of the oral microbiome via a single polyphenol- and fiber-dense meal plan creates an immediate shift in the microbial composition of involuntary nocturnal microaspiration droplets. Upon entry into the lower respiratory tract, this eubiotic bacterial influx acts as an acute molecular signal that rapidly modulates microglia reactivity and neuroinflammation via the lung-brain axis, bypassing systemic colonic metabolite transport.

Dietary modification _gates_from_dietary_modification Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Respiratory Aspiration _gates_to_respiratory_aspiration _gates_from_respiratory_aspiration Microglia _gates_to_microglia
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Experiment #00000129

COPD Dietary Idea: According to PubMed literature, he following lunchtime meal plan provides nutrients needed for production and regulation of tryptophan and 3-IPA and may help reduce COPD flare-ups, while also providing mucosal support for clearance of debris from the lungs: -2x slices sourdough bread, lightly spread with extra virgin olive oil, garlic, and ginger, with 2x slices of cooked turkey and spinach, with nutritional yeast and hi-maize corn starch mixed into the EVOO (for mucosal system support) -a spinach-based salad with 1 Tbsp EVOO -3 oz pomegranate juice mixed with 3 oz cherry juice

Tryptophan _gates_from_tryptophan Gut Microbiota _gates_to_gut_microbiota _gates_from_gut_microbiota Indolepropionic Acid _gates_to_indolepropionic_acid IPA _gates_from_ipa Lung
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Experiment #00000126

Hypothesis: Intranasal delivery of Spermidine-modified Ginseng Extracellular Vesicles (S-GEVs) loaded with multi-targeted mRNA suppresses MARK2-eIF2α-driven RAN translation to prevent dipeptide repeat clogging of FG-nucleoporins, synergizing with progranulin-mediated lysosomal clearance to arrest TMEM106B amyloid accumulation and block the execution of p38-Lamin B1-dependent Karyoptosis in motor neurons.

Spermidine _gates_from_spermidine Lysosomal Degradation _gates_to_lysosomal_degradation _gates_from_lysosomal_degradation Protein Aggregates _gates_to_protein_aggregates _gates_from_protein_aggregates Cell Death _gates_to_cell_death
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Experiment #00000124

Hypothesis: Intranasal delivery of Spermidine-modified Ginseng Extracellular Vesicles (S-GEVs) loaded with GRN mRNA exploits the cribriform plate anatomy to bypass the blood-brain barrier, providing a neuro-targeted delivery system for progranulin gene therapy that acts synergistically with spermidine-induced autophagy to suppress pathological TMEM106B amyloid accumulation and restore endolysosomal homeostasis.

Administration, Intranasal _gates_from_administration__intranasal Olfactory Bulb _gates_to_olfactory_bulb Progranulins _gates_from_progranulins _gates_to_progranulins RNA, Messenger _gates_from_rna__messenger PGRN protein
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Experiment #00000123

Hypothesis: Intranasal delivery of Spermidine-modified Ginseng Extracellular Vesicles (S-GEVs) loaded with GRN mRNA exploits the cribriform plate anatomy to bypass the blood-brain barrier, providing a neuro-targeted delivery system for progranulin gene therapy that acts synergistically with spermidine-induced autophagy to suppress pathological TMEM106B amyloid accumulation and restore endolysosomal homeostasis.

Administration, Intranasal _gates_from_administration__intranasal Olfactory Bulb _gates_to_olfactory_bulb Progranulins _gates_from_progranulins _gates_to_progranulins RNA, Messenger _gates_from_rna__messenger PGRN protein
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Experiment #00000119

Hypothesis: Considering PubMed #41177462, Intranasally administered GDEVs, specifically spermidine-modified ginger extracellular vesicles, may offer a multi-target therapeutic strategy for C9orf72-associated ALS by crossing the blood-brain barrier via olfactory routes to potentially deliver gene-editing components, support axonal translation, restore STMN2 expression, and attenuate neuroinflammation.

Spermidine _gates_from_spermidine Olfactory Bulb _gates_to_olfactory_bulb Drug Delivery Systems _gates_from_drug_delivery_systems Stathmin 2 _gates_to_stathmin_2 Eukaryotic Initiation Factor-5A _gates_from_eukaryotic_initiation_factor_5a
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Experiment #00000118

Environmental plant-derived extracellular vesicles (such as those from pollen or agricultural dust) may act as stealth vectors via nasal-olfactory pathways, potentially delivering environmental toxins or pathogenic RNAs that bypass the BBB and trigger neurodegenerative pathologies, such as Amyotrophic Lateral Sclerosis.

Olfactory Pathways _gates_from_olfactory_pathways Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles Biological Factors _gates_to_biological_factors _gates_from_biological_factors Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis
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Experiment #00000117

Ginger Derived Extracellular Vesicles may be a therapeutic hack for nasal C9orf72 CRISPR delivery, bypassing the BBB via nerve pathways to widely distribute gene edits without toxicity.

Drug Delivery Systems _gates_from_drug_delivery_systems _gates_to_drug_delivery_systems CRISPR-Cas Systems _gates_to_crispr_cas_systems Nanoparticles _gates_from_nanoparticles Blood-Brain Barrier _gates_to_blood_brain_barrier Intranasal Administration
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Experiment #00000114

Biohack, Anti-Ebola Hypothesis 1: PDEV-to-macrophage siRNA targeting VP40 Load the plant vesicles with synthetic siRNAs designed to silence VP40 transcription directly inside the macrophage. Exploration of dietary, pharmacological, and repurposed solutions to achieve this.

PDEV isolation _gates_from_pdev_isolation RNA, Small Interfering _gates_to_rna__small_interfering _gates_from_rna__small_interfering Macrophage Activation _gates_to_macrophage_activation _gates_from_macrophage_activation Gene Silencing _gates_to_gene_silencing
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Experiment #00000111

Identify specific patterns of TDP-43 proteinopathy induced cryptic mis-splicing of STMN2 and other "cryptic mis-splicing" patterns found within PubMed Literature, 2026.

DNA-Binding Protein 43 _gates_from_dna_binding_protein_43 Exons _gates_to_exons _gates_from_exons Protein Deficiency _gates_to_protein_deficiency Functional Protein Loss _gates_from_functional_protein_loss Neurodegeneration
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Experiment #00000105

Gap Analysis: There is no PubMed data showing wet lab data or analysis of TPD-43 proteinopathy found (or not found) in the Cochlear, Spiral, or Scarpa's Ganglion of Amyotrophic Lateral Sclerosis patient data post mortem.

Amyotrophic Lateral Sclerosis _gates_from_amyotrophic_lateral_sclerosis TDP-43 proteinopathy _gates_to_tdp_43_proteinopathy _gates_from_tdp_43_proteinopathy Spiral Ganglion _gates_to_spiral_ganglion Peripheral Nerves _gates_from_peripheral_nerves _gates_to_amyotrophic_lateral_sclerosis
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Experiment #00000101

Hypothesis: If Botox were injected into the nerve ending on the third toe on the left foot, the toxin can "climb" retrograde from toe through motor neurons eventually to the brain and temporarily inhibit vesicular docking "from toe to head", potentially allowing a timed pharmacological therapeutic window for toxic EV clearance through the lymph system instead of docking and seeding.

Botulinum Toxins, Type A _gates_from_botulinum_toxins__type_a Axonal Transport _gates_to_axonal_transport _gates_from_axonal_transport SNARE Proteins _gates_to_snare_proteins _gates_from_snare_proteins Lymphatic Vessel Endothelial Hyaluronan Receptor-1 _gates_to_lymphatic_vessel_endothelial_hyaluronan_receptor_1
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Experiment #00000091

Context:A patient is brought into a remote aid station after an explosion inside a covert manufacturing facility. They have a known concussive blast injury, moderate skin irritation, and potential unknown chemical inhalation.Patient Clinical Presentation:Physical Trauma: Grade 2 concussion (confusion, mild disorientation, reactive pupils).Dermatological: Superficial skin burning and blistering across the forearms. The skin smells faintly of burnt almonds or cut grass.Respiratory/Systemic: Shortness of breath, mild tachypnea, and sudden, severe muscle twitching (fasciculations) that began 10 minutes post-exposure.Operational Constraint:Standard advanced diagnostics are unavailable. The primary treatment kit contains standard trauma items, atropine/pralidoxime (2-PAM) autoinjectors, sodium thiosulfate, hydroxycobalamin, and basic field-expedient wellness supplies.Scan Instructions:Run a single scan over the medical and toxicological corpus to map this multi-system presentation. Provide the following outputs using Veridical Enforcement:Differential Toxin Ranking: Based on the combination of blast concussion, skin burning, and the specific onset of muscle twitching vs. scent clues, identify and rank the top two most likely overlapping chemical exposure pathways.The Dynamic Counter-Response (The "If/Then" Fork): Map the exact treatment-response trap. If I suspect Toxin A and administer standard Countermeasure X (e.g., an anticholinergic like atropine), but the patient’s fasciculations instantly stop while their blood pressure dangerously spikes and pupils violently dilate, what secondary hidden pathway does this reaction reveal?Veridical Contraindications: Explicitly cite the exact physiological mechanisms and PubMed-grounded parameters where standard concussion management (e.g., specific fluid resuscitation volumes or sedatives) directly exacerbates the cellular hypoxia or neurotoxicity caused by the suspected chemical inhalants. Do not hallucinate or approximate citations.

Blast Injuries _gates_from_blast_injuries Toxicology _gates_to_toxicology Fasciculations _gates_from_fasciculations Cholinesterase Inhibitors _gates_to_cholinesterase_inhibitors
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Experiment #00000084

SOD1 Research July 2026

Genetic Testing _gates_from_genetic_testing Drug Delivery Systems _gates_to_drug_delivery_systems _gates_from_drug_delivery_systems Superoxide Dismutase-1 _gates_to_superoxide_dismutase_1 Protein Aggregates _gates_from_protein_aggregates Oxidative Stress
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Experiment #00000082

Microbiota-derived acetate can alleviate neurological inflammation and neurodegeneration induced by hypoxia via the upregulation of brain-derived neurotrophic factor (BDNF).

Hypoxia _gates_from_hypoxia Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Acetic Acid _gates_to_acetic_acid _gates_from_acetic_acid Neuroinflammation _gates_to_neuroinflammation
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Experiment #00000081

How does the gut microbiome modulate inflammation?

Microbial Dysbiosis _gates_from_microbial_dysbiosis Permeability _gates_to_permeability _gates_from_permeability Bacterial Translocation _gates_to_bacterial_translocation _gates_from_bacterial_translocation Toll-Like Receptor 4 _gates_to_toll_like_receptor_4
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Experiment #00000080

Prenatal iron deficiency (ID) exacerbates the risk of sudden infant death syndrome (SIDS) by modulating the expression of the hypothalamic orexin system, impairing homeostatic arousal mechanisms during hypoxia.

Anemia, Iron-Deficiency _gates_from_anemia__iron_deficiency Hypothalamic-Hypophyseal System _gates_to_hypothalamic_hypophyseal_system _gates_from_hypothalamic_hypophyseal_system Sudden Infant Death _gates_to_sudden_infant_death _gates_from_sudden_infant_death Orexins _gates_to_orexins
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Experiment #00000079

Why do seemingly perfectly healthy infants suddenly pass away in their sleep?

Infant, Newborn _gates_from_infant__newborn Autonomic Nervous System _gates_to_autonomic_nervous_system _gates_from_autonomic_nervous_system Death, Sudden _gates_to_death__sudden _gates_from_death__sudden Sudden Infant Death _gates_to_sudden_infant_death
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Experiment #00000078

Activated STING triggers inflammatory cytokines that directly drive astrocytic AQP4 depolarization; dampening this pathway restores the perivascular endfoot morphology necessary for glymphatic flow.

Metabolic Stress _gates_from_metabolic_stress DNA, Mitochondrial _gates_to_dna__mitochondrial _gates_from_dna__mitochondrial cGAS-STING Pathway _gates_to_cgas_sting_pathway _gates_from_cgas_sting_pathway Neuroinflammation _gates_to_neuroinflammation
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Experiment #00000077

The use of lysosome-acidifying nanoparticles (AcNPs) could potentially be adapted to treat nanoplastic-induced lysosomal alkalization or membrane rigidification, as these nanoparticles act to restore the degradative capacity lost during environmental contaminant stress.

Nanoplastic exposure _gates_from_nanoplastic_exposure Lysosomes _gates_to_lysosomes _gates_from_lysosomes Autophagy _gates_to_autophagy Nanoparticles _gates_from_nanoparticles Hydrogen-Ion Concentration
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Experiment #00000076

Nanoplastic-induced lysosomal membrane remodeling may sequester WDR44, creating a 'hotspot' for α-synuclein aggregation initiation.

Nanoplastics internalization _gates_from_nanoplastics_internalization Lysosomal accumulation _gates_to_lysosomal_accumulation _gates_from_lysosomal_accumulation Lysosomal Membranes _gates_to_lysosomal_membranes WDR44 _gates_from_wdr44 WDR44 protein
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Experiment #00000070

What types of infections might cause a high C-Reactive Protein result?

Pathogen presence _gates_from_pathogen_presence Immunity, Innate _gates_to_immunity__innate _gates_from_immunity__innate C-Reactive Protein _gates_to_c_reactive_protein _gates_from_c_reactive_protein Biomarkers _gates_to_biomarkers
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Experiment #00000069

Keyword Analysis: diabetes; retinal diabetic neuropathy; ganglion cells; synapses; SPG302; tazbentetol; visual function; synaptic regeneration; neuroprotection; blindness; glaucoma

Glucose _gates_from_glucose Mitochondria _gates_to_mitochondria Mitochondrial Dysfunction _gates_from_mitochondrial_dysfunction Retinal Ganglion Cells _gates_to_retinal_ganglion_cells SPG302 Treatment _gates_from_spg302_treatment
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Experiment #00000065

Does pathologically seeded TDP-43 exit the retina via anterograde axonal transport along the optic tract to midbrain hubs, enter the systemic circulation inside extracellular vesicles, and subsequently traffic into pancreatic beta-cells to accelerate type 2 diabetes phenotypes?

TAR DNA-Binding Protein 43 _gates_from_tar_dna_binding_protein_43 Extracellular Vesicles _gates_to_extracellular_vesicles Systemic circulating EVs _gates_from_systemic_circulating_evs Insulin-Secreting Cells _gates_to_insulin_secreting_cells Axonal Transport _gates_to_axonal_transport
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Experiment #00000064

Lon Protease, Alternaria; IL-33; TSLP; alarmins; asthma; chronic rhinosinusitis; fungal allergen; innate lymphoid cells

Alternaria _gates_from_alternaria Alarmins _gates_to_alarmins _gates_from_alarmins Immunity, Innate _gates_to_immunity__innate _gates_from_immunity__innate Lon-Peptidase _gates_to_lon_peptidase
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Experiment #00000062

NESCO-induced pyroptosis in the peritoneal microenvironment might be attenuated by the upregulation of 11-oxygenated androgens in the systemic circulation.

Endometriosis _gates_from_endometriosis Tumor Microenvironment _gates_to_tumor_microenvironment Androgens _gates_from_androgens _gates_to_endometriosis Disease Models, Animal _gates_from_disease_models__animal NESCO and Androgens
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Experiment #00000057

Amyotrophic Lateral Sclerosis breakthrough updates as of July 2026

Systemic Disease _gates_from_systemic_disease Gene Expression Regulation _gates_to_gene_expression_regulation
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Experiment #00000048

The ALS-T2D comorbidity is driven by a bidirectional, exosome-mediated proteostatic collapse. Peripheral tissues (muscle, pancreas) dictate CNS TDP-43 stability via exosomal miRNAs (miR-126a-5p) and glucose-dependent modifications (O-GlcNAcylation). Conversely, pharmacological activation of ubiquitin-peptidases (e.g., Acarbose targeting USP46) or restitution of glycolytic cofactors (F2,6BP) represent novel, cross-disciplinary therapeutic targets capable of halting systemic proteinopathy.

Diabetes Mellitus, Type 2 _gates_from_diabetes_mellitus__type_2 Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles DNA-Binding Proteins _gates_to_dna_binding_proteins _gates_from_dna_binding_proteins Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis
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Experiment #00000047

Does blast-induced mild traumatic brain injury (mTBI) drive progressive tau/TDP-43 seeding by disrupting astrocytic AQP4 glymphatic clearance and activating microglial cGAS-STING neuroinflammation? #mTBI #Glymphatic #cGASSTING

Blast Injuries _gates_from_blast_injuries Aquaporin 4 _gates_to_aquaporin_4 _gates_from_aquaporin_4 Glymphatic System _gates_to_glymphatic_system _gates_from_glymphatic_system Protein Aggregates _gates_to_protein_aggregates
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Experiment #00000046

How does knitting help improve mental health?

Knitting _gates_from_knitting Psychophysiology _gates_to_psychophysiology _gates_from_psychophysiology Neurotransmitter Release _gates_to_neurotransmitter_release _gates_from_neurotransmitter_release Anxiety _gates_to_anxiety
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Experiment #00000041

What is the biological/molecular pathway that causes sarcopenia with the scope of COPD? Do the quads serve as a pathological progression indicator?

Pulmonary Disease, Chronic Obstructive _gates_from_pulmonary_disease__chronic_obstructive Systemic Inflammatory Response Syndrome _gates_to_systemic_inflammatory_response_syndrome _gates_from_systemic_inflammatory_response_syndrome Signal Transduction _gates_to_signal_transduction _gates_from_signal_transduction Muscular Atrophy _gates_to_muscular_atrophy
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Experiment #00000040

Can inhaled COVID-19 vaccinations be used to help treat COPD?

Pulmonary Disease, Chronic Obstructive _gates_from_pulmonary_disease__chronic_obstructive Administration, Inhalation _gates_to_administration__inhalation _gates_from_administration__inhalation Immunity, Mucosal _gates_to_immunity__mucosal Mucous Membrane _gates_to_mucous_membrane _gates_from_mucous_membrane
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Experiment #00000038

Map the direct mechanical and axonal transport pathways connecting intranasal administration or trigeminal nerve delivery to the clearance of TDP-43 aggregates in sporadic ALS, and the delivery of CRISPR-Cas/ASO gene therapies targeting C9orf72 hexanucleotide repeat expansions in the cerebellum and brainstem.

Intranasal Route _gates_from_intranasal_route Blood-Brain Barrier _gates_to_blood_brain_barrier C9orf72 Protein _gates_to_c9orf72_protein _gates_from_c9orf72_protein Brain _gates_to_brain Intranasal Administration
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Experiment #00000031

Why are frontotemporal dementia and c9orf72 ALS considered different diseases if they are both driven by the same abnormal expansion of a GGGGCC (G₄C₂) sequence in the first intron of the C9orf72 gene? Is it logical to think that CRISPR therapeutics for FTD potentially be used for ALS as well?

C9orf72 expansion _gates_from_c9orf72_expansion Gene Expression Regulation _gates_to_gene_expression_regulation _gates_from_gene_expression_regulation Protein Aggregation, Pathological _gates_to_protein_aggregation__pathological _gates_from_protein_aggregation__pathological CRISPR-Cas Systems _gates_to_crispr_cas_systems
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Experiment #00000030

Can AI and single-cell RNA sequencing help map cryptic TDP-43 splicing errors in sporadic ALS to design BBB-penetrant CRISPR gene therapies before neurotoxicity begins?

Single-Cell Analysis _gates_from_single_cell_analysis RNA Splicing _gates_to_rna_splicing _gates_from_rna_splicing Blood-Brain Barrier _gates_to_blood_brain_barrier _gates_from_blood_brain_barrier Neurotoxicity Syndromes _gates_to_neurotoxicity_syndromes
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Experiment #00000023

Does misfolded TDP43 affect Retinal Ganglion Cell STMN2 ability to repair in a similar way as what how it was shown to affect motor neurons with cryptic mis-splicing?

TDP-43 pathology _gates_from_tdp_43_pathology RNA Splicing _gates_to_rna_splicing _gates_from_rna_splicing Stathmin 2 _gates_to_stathmin_2 Vitreous Body _gates_to_vitreous_body DNA-Binding Protein-43
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Experiment #00000020

Does age-related gut dysbiosis drive sarcopenia by activating the cGAS-STING inflammatory pathway to suppress satellite cell renewal?

Gastrointestinal Microbiome _gates_from_gastrointestinal_microbiome Inflammation _gates_to_inflammation _gates_from_inflammation cGAS-STING Pathway Activation _gates_to_cgas_sting_pathway_activation _gates_from_cgas_sting_pathway_activation Satellite Cells _gates_to_satellite_cells
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Experiment #00000018

Can smoking cigarettes cause dysbiosis?

Tobacco Smoke Pollution _gates_from_tobacco_smoke_pollution Epithelium _gates_to_epithelium _gates_from_epithelium Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Immune System Diseases _gates_to_immune_system_diseases
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Experiment #00000017

How does the gut-brain axis play a role in Alzheimer's Disease? Is there a potential link for gut-brain axis for other neurological disorders such as Amyotrophic Lateral Sclerosis?

Dysbiosis _gates_from_dysbiosis Intestinal Permeability _gates_to_intestinal_permeability _gates_from_intestinal_permeability Systemic Inflammatory Response Syndrome _gates_to_systemic_inflammatory_response_syndrome _gates_from_systemic_inflammatory_response_syndrome Neuroinflammation _gates_to_neuroinflammation
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Experiment #00000016

Analyze the potential for zinc-binding competition between synaptic transporters (e.g., SLC39A8, ZnT3) and ALS-associated proteins (RGNEF, TDP-43) in the RGC-thalamic axis. Can this competition explain the coexistence of RGC excitotoxicity and STMN2 depletion in clinical samples?

TAR DNA-Binding Protein 43 _gates_from_tar_dna_binding_protein_43 Stathmin 2 _gates_to_stathmin_2 SLC39A8 protein, human _gates_from_slc39a8_protein__human Zinc _gates_to_zinc Excitotoxicity _gates_from_excitotoxicity
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Experiment #00000015

Given that schizophrenia is characterized by a deficit in the attenuation of sensory input via corollary discharge, how might pathologically elevated RGC signaling—potentially caused by synaptic glutamate overflow without zinc modulation—interfere with the thalamic integration of extra-retinal CD signals to effectively reverse the predictive timing of visual stability?

SLC39A8 Protein _gates_from_slc39a8_protein Zinc Deficiency _gates_to_zinc_deficiency _gates_from_zinc_deficiency Glutamic Acid _gates_to_glutamic_acid _gates_from_glutamic_acid Thalamus _gates_to_thalamus
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Experiment #00000014

Under certain conditions, can hyperexcited retinal ganglion cells misfire corollary discharge(s) unexpectedly?

Oculomotor Motor Command _gates_from_oculomotor_motor_command Corollary Discharge _gates_to_corollary_discharge _gates_from_corollary_discharge Sensory Processing, Sensory _gates_to_sensory_processing__sensory Retinal Ganglion Cells (RGCs) _gates_from_retinal_ganglion_cells__rgcs_ Visual Perception
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Experiment #00000013

Can BMAA, a known glutamate mimic, cause hyperexcited retinal ganglion cells and cause them to "misfire" corollary discharge?

Amino Acids, Diamino _gates_from_amino_acids__diamino Retina _gates_to_retina _gates_from_retina Corollary Discharge _gates_to_corollary_discharge NMDA receptors _gates_to_nmda_receptors NMDA receptor activation
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Experiment #00000010

How long after a tick bite does it take before Lyme disease can be detected by a blood test?

Tick Bite _gates_from_tick_bite Infection/Colonization _gates_to_infection_colonization _gates_from_infection_colonization Serologic Tests _gates_to_serologic_tests _gates_from_serologic_tests False Negative Reactions _gates_to_false_negative_reactions
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Experiment #00000006

Does existing in vitro data show that Quercetin-induced autophagy can successfully degrade DUX4 or its downstream misfolded proteins?

Quercetin _gates_from_quercetin Autophagy _gates_to_autophagy _gates_from_autophagy Misfolded Proteins _gates_to_misfolded_proteins _gates_from_misfolded_proteins DUX4 _gates_to_dux4
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