PathMap Literature Based Discovery Engine

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Experiment #00000108

Restoration of efferocytosis is highly dependent on macrophage polarization states; M1 and M2 phenotypes can both contribute to resolution if metabolic cues are corrected.

Metabolic Signaling _gates_from_metabolic_signaling Efferocytic Capacity _gates_to_efferocytic_capacity PIEZO1 Protein _gates_from_piezo1_protein Calcium Influx _gates_to_calcium_influx _gates_from_calcium_influx Metabolic/Efferocytic Pathways
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Experiment #00000107

Restored Clearance of Senescent Neutrophils: Suggested Studies for Limiting Organ Aging

Neutrophils _gates_from_neutrophils Chronic Inflammation (Inflammaging) _gates_to_chronic_inflammation__inflammaging_ Chronic Inflammation _gates_from_chronic_inflammation Efferocytosis _gates_to_efferocytosis Pharmacological Phenomena _gates_from_pharmacological_phenomena
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Experiment #00000020

Does age-related gut dysbiosis drive sarcopenia by activating the cGAS-STING inflammatory pathway to suppress satellite cell renewal?

Gastrointestinal Microbiome _gates_from_gastrointestinal_microbiome Inflammation _gates_to_inflammation _gates_from_inflammation cGAS-STING Pathway Activation _gates_to_cgas_sting_pathway_activation _gates_from_cgas_sting_pathway_activation Satellite Cells _gates_to_satellite_cells
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