PathMap Literature Based Discovery Engine
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ALS; FUS; STMN2; TDP-43; protein translation; stress granule


Frontotemporal dementia; Splicing; TDP-43; Transcriptomics.


Sarcopenia and Amyotrophic Lateral Sclerosis: Biological Pathways and Analysis


The ALS-T2D comorbidity is driven by a bidirectional, exosome-mediated proteostatic collapse. Peripheral tissues (muscle, pancreas) dictate CNS TDP-43 stability via exosomal miRNAs (miR-126a-5p) and glucose-dependent modifications (O-GlcNAcylation). Conversely, pharmacological activation of ubiquitin-peptidases (e.g., Acarbose targeting USP46) or restitution of glycolytic cofactors (F2,6BP) represent novel, cross-disciplinary therapeutic targets capable of halting systemic proteinopathy.


Diabetes Mellitus, Type 2
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Extracellular Vesicles
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DNA-Binding Proteins
_gates_to_dna_binding_proteins
_gates_from_dna_binding_proteins
Amyotrophic Lateral Sclerosis
_gates_to_amyotrophic_lateral_sclerosis
What kinds of changes in voice occur prior to Amyotrophic Lateral Sclerosis onset?


What is Karyoptosis and how does it align with past and present neurodegenerative disease research? Does Karyoptosis provide a new context in which a new class of repurposed therapeutics is formed?


Proteotoxic Stress
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Cyclic AMP-Response Element Binding Protein
_gates_to_cyclic_amp_response_element_binding_protein
_gates_from_cyclic_amp_response_element_binding_protein
Nuclear Envelope
_gates_to_nuclear_envelope
_gates_from_nuclear_envelope
Apoptosis
_gates_to_apoptosis
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