PathMap Literature Based Discovery Engine
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Guaranteed to find unpublished literature based discoveries.
Hypothesis: If Botox were injected into the nerve ending on the third toe on the left foot, the toxin can "climb" retrograde from toe through motor neurons eventually to the brain and temporarily inhibit vesicular docking "from toe to head", potentially allowing a timed pharmacological therapeutic window for toxic EV clearance through the lymph system instead of docking and seeding.


Botulinum Toxins, Type A
_gates_from_botulinum_toxins__type_a
Axonal Transport
_gates_to_axonal_transport
_gates_from_axonal_transport
SNARE Proteins
_gates_to_snare_proteins
_gates_from_snare_proteins
Lymphatic Vessel Endothelial Hyaluronan Receptor-1
_gates_to_lymphatic_vessel_endothelial_hyaluronan_receptor_1
Stabilizing the CREB3 tether via S1P/S2P protease inhibition represents a novel mechanism to prevent the terminal phase of neuronal death.


Endoplasmic Reticulum Stress
_gates_from_endoplasmic_reticulum_stress
Proteolysis
_gates_to_proteolysis
_gates_from_proteolysis
Cyclic AMP-Response Element-Binding Protein
_gates_to_cyclic_amp_response_element_binding_protein
_gates_from_cyclic_amp_response_element_binding_protein
Nuclear Envelope
_gates_to_nuclear_envelope
SOD1 Research July 2026


ALS; FUS; STMN2; TDP-43; protein translation; stress granule


Frontotemporal dementia; Splicing; TDP-43; Transcriptomics.







