PathMap Literature Based Discovery Engine

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Experiment #00000139

Foundational Dietary Theory: The dietary synergy between Hi-Maize and 6x Spermidine Yeast creates a potential cellular supply-and-clearance loop within the brain's astrocytes. Circulating spermidine metabolites utilize documented astrocytic polyamine uptake systems to access the central nervous system. Once inside, this exogenous spermidine drives FAM134B-mediated ER-phagy, clearing the endoplasmic reticulum matrix. This clearance removes the ER-stress bottleneck, allowing newly transcribed astrocytic EAAT2—upregulated by gut-derived butyrate from Hi-Maize fermentation—to successfully traffic to the plasma membrane and mitigate synaptic glutamate excitotoxicity.

Starch, Resistant _gates_from_starch__resistant Butyric Acid _gates_to_butyric_acid _gates_from_butyric_acid Glutamate Plasma Membrane Transport Proteins _gates_to_glutamate_plasma_membrane_transport_proteins Spermidine _gates_from_spermidine Autophagy
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Experiment #00000138

Dietary butyrate from resistant starch may synergize with sulforaphane-driven Nrf2 activation and spermidine-mediated FAM134B ER-phagy in order to restore astrocytic EAAT2 membrane trafficking and potentially clear synaptic glutamate excitotoxicity in neurodegeneration. (Literature Based Discovery)

Starch, Resistant _gates_from_starch__resistant Butyrate _gates_to_butyrate _gates_from_butyrate NF-E2-Related Factor 2 _gates_to_nf_e2_related_factor_2 Sulforaphane _gates_from_sulforaphane Spermidine
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Experiment #00000136

Borneol-mediated membrane permeability can enhance the therapeutic delivery of plant-derived extracellular vesicles to deep-seated endometriotic lesions, bridging the gap between existing delivery enhancements for CNS ischemia and local anti-fibrotic treatments.

Borneol _gates_from_borneol Drug Delivery Systems _gates_to_drug_delivery_systems _gates_from_drug_delivery_systems Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles Fibrosis _gates_to_fibrosis
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Experiment #00000127

Neuroinflammatory astrocyte subtypes in the mouse brain

Pathologic Processes _gates_from_pathologic_processes Gene Expression Regulation _gates_to_gene_expression_regulation _gates_from_gene_expression_regulation Biological Phenomena _gates_to_biological_phenomena _gates_from_biological_phenomena Neuroinflammatory Diseases _gates_to_neuroinflammatory_diseases
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Experiment #00000113

COPD Related Alveoli and Lung Microbiome Axis Restoration Hypothesis: The use of 'pre-digested' (fermented) plant-based nutritional additives as a means to circumvent the bioavailability paradox in patients with gut dysbiosis, effectively using botanical matrices as drug-delivery vehicles. Nucleotide supplementation may enhance the ability of A. muciniphila to modulate gut mucosal barrier integrity in hyperuricemia patients. *Akkermansia* possesses unique enzymes (β-N-acetylhexosaminidases) that allow it to colonize the mucosal layer and participate in mucin degradation.

Fermentation _gates_from_fermentation Bioavailability _gates_to_bioavailability _gates_from_bioavailability Homeostasis _gates_to_homeostasis Plant Preparations _gates_from_plant_preparations Probiotics
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Experiment #00000089

Use of MBTPS1 inhibitors is a plausible strategy to prevent the terminal phase of nuclear death in specific cellular contexts.

Membrane-Bound Transcription Factor Peptidase, Site 1 _gates_from_membrane_bound_transcription_factor_peptidase__site_1 SREBP Activation _gates_to_srebp_activation _gates_from_srebp_activation Cellular Lipid Homeostasis _gates_to_cellular_lipid_homeostasis _gates_from_cellular_lipid_homeostasis Terminal Cell Death _gates_to_terminal_cell_death
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Experiment #00000077

The use of lysosome-acidifying nanoparticles (AcNPs) could potentially be adapted to treat nanoplastic-induced lysosomal alkalization or membrane rigidification, as these nanoparticles act to restore the degradative capacity lost during environmental contaminant stress.

Nanoplastic exposure _gates_from_nanoplastic_exposure Lysosomes _gates_to_lysosomes _gates_from_lysosomes Autophagy _gates_to_autophagy Nanoparticles _gates_from_nanoparticles Hydrogen-Ion Concentration
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Experiment #00000076

Nanoplastic-induced lysosomal membrane remodeling may sequester WDR44, creating a 'hotspot' for α-synuclein aggregation initiation.

Nanoplastics internalization _gates_from_nanoplastics_internalization Lysosomal accumulation _gates_to_lysosomal_accumulation _gates_from_lysosomal_accumulation Lysosomal Membranes _gates_to_lysosomal_membranes WDR44 _gates_from_wdr44 WDR44 protein
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Experiment #00000075

Polystyrene nanoplastics (PS-NPs) may act as a scaffold for the recruitment and accumulation of WDR44 at the lysosomal membrane, thereby accelerating the de novo aggregation of alpha-synuclein in the early stages of PD.

Nanoplastic exposure _gates_from_nanoplastic_exposure Lysosomal Storage Diseases _gates_to_lysosomal_storage_diseases _gates_from_lysosomal_storage_diseases alpha-Synuclein _gates_to_alpha_synuclein WDR44 _gates_from_wdr44 Protein Aggregates
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Experiment #00000040

Can inhaled COVID-19 vaccinations be used to help treat COPD?

Pulmonary Disease, Chronic Obstructive _gates_from_pulmonary_disease__chronic_obstructive Administration, Inhalation _gates_to_administration__inhalation _gates_from_administration__inhalation Immunity, Mucosal _gates_to_immunity__mucosal Mucous Membrane _gates_to_mucous_membrane _gates_from_mucous_membrane
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Experiment #00000009

How does autophagy work?

Cellular Stress _gates_from_cellular_stress Autophagy _gates_to_autophagy _gates_from_autophagy Phagosomes _gates_to_phagosomes _gates_from_phagosomes Apoptosis _gates_to_apoptosis
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