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Experiment #00000131

Premise: Environmental metals, though present in many Amyotrophic Lateral Sclerosis anomalous clusters, are debated regarding causality within geographic epistemological data. Hypothesis: If plant derived extracellular vesicles (PDEVs) aerosolized with environmental metals, they could potentially bypass the blood brain barrier via the cribriform plate area. Given this potential method of delivery, environmental metals cannot be ruled out as causal in sporadic ALS until PDEV delivery of the metals is tested in wet lab experiments, but may potentially explain the confounding data.

Environmental Pollutants _gates_from_environmental_pollutants PDEV association _gates_to_pdev_association _gates_from_pdev_association Nose-to-Brain Delivery _gates_to_nose_to_brain_delivery _gates_from_nose_to_brain_delivery Brain Diseases _gates_to_brain_diseases
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Experiment #00000118

Environmental plant-derived extracellular vesicles (such as those from pollen or agricultural dust) may act as stealth vectors via nasal-olfactory pathways, potentially delivering environmental toxins or pathogenic RNAs that bypass the BBB and trigger neurodegenerative pathologies, such as Amyotrophic Lateral Sclerosis.

Olfactory Pathways _gates_from_olfactory_pathways Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles Biological Factors _gates_to_biological_factors _gates_from_biological_factors Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis
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Experiment #00000114

Biohack, Anti-Ebola Hypothesis 1: PDEV-to-macrophage siRNA targeting VP40 Load the plant vesicles with synthetic siRNAs designed to silence VP40 transcription directly inside the macrophage. Exploration of dietary, pharmacological, and repurposed solutions to achieve this.

PDEV isolation _gates_from_pdev_isolation RNA, Small Interfering _gates_to_rna__small_interfering _gates_from_rna__small_interfering Macrophage Activation _gates_to_macrophage_activation _gates_from_macrophage_activation Gene Silencing _gates_to_gene_silencing
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