PathMap Literature Based Discovery Engine
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Frontotemporal dementia; Splicing; TDP-43; Transcriptomics.


Sarcopenia and Amyotrophic Lateral Sclerosis: Biological Pathways and Analysis


What kinds of changes in voice occur prior to Amyotrophic Lateral Sclerosis onset?


What is Karyoptosis and how does it align with past and present neurodegenerative disease research? Does Karyoptosis provide a new context in which a new class of repurposed therapeutics is formed?


Proteotoxic Stress
_gates_from_proteotoxic_stress
Cyclic AMP-Response Element Binding Protein
_gates_to_cyclic_amp_response_element_binding_protein
_gates_from_cyclic_amp_response_element_binding_protein
Nuclear Envelope
_gates_to_nuclear_envelope
_gates_from_nuclear_envelope
Apoptosis
_gates_to_apoptosis
Why are frontotemporal dementia and c9orf72 ALS considered different diseases if they are both driven by the same abnormal expansion of a GGGGCC (G₄C₂) sequence in the first intron of the C9orf72 gene? Is it logical to think that CRISPR therapeutics for FTD potentially be used for ALS as well?


C9orf72 expansion
_gates_from_c9orf72_expansion
Gene Expression Regulation
_gates_to_gene_expression_regulation
_gates_from_gene_expression_regulation
Protein Aggregation, Pathological
_gates_to_protein_aggregation__pathological
_gates_from_protein_aggregation__pathological
CRISPR-Cas Systems
_gates_to_crispr_cas_systems
How does the gut-brain axis play a role in Alzheimer's Disease? Is there a potential link for gut-brain axis for other neurological disorders such as Amyotrophic Lateral Sclerosis?


Dysbiosis
_gates_from_dysbiosis
Intestinal Permeability
_gates_to_intestinal_permeability
_gates_from_intestinal_permeability
Systemic Inflammatory Response Syndrome
_gates_to_systemic_inflammatory_response_syndrome
_gates_from_systemic_inflammatory_response_syndrome
Neuroinflammation
_gates_to_neuroinflammation
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