PathMap Literature Based Discovery Engine

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Experiment #00000036

What is Karyoptosis and how does it align with past and present neurodegenerative disease research? Does Karyoptosis provide a new context in which a new class of repurposed therapeutics is formed?

Proteotoxic Stress _gates_from_proteotoxic_stress Cyclic AMP-Response Element Binding Protein _gates_to_cyclic_amp_response_element_binding_protein _gates_from_cyclic_amp_response_element_binding_protein Nuclear Envelope _gates_to_nuclear_envelope _gates_from_nuclear_envelope Apoptosis _gates_to_apoptosis

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Experiment #00000033

Acinetobacter baumannii and Pseudomonas may share pathways with other pathologies and there may be therapeutic bacteriophages or other non-antibiotic solutions hidden with in PubMed literature.

Drug Resistance, Multiple, Bacterial _gates_from_drug_resistance__multiple__bacterial Anti-Bacterial Agents _gates_to_anti_bacterial_agents Multidrug resistance _gates_from_multidrug_resistance Therapeutics _gates_to_therapeutics Biofilms _gates_from_biofilms

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Experiment #00000031

Why are frontotemporal dementia and c9orf72 ALS considered different diseases if they are both driven by the same abnormal expansion of a GGGGCC (G₄C₂) sequence in the first intron of the C9orf72 gene? Is it logical to think that CRISPR therapeutics for FTD potentially be used for ALS as well?

C9orf72 expansion _gates_from_c9orf72_expansion Gene Expression Regulation _gates_to_gene_expression_regulation _gates_from_gene_expression_regulation Protein Aggregation, Pathological _gates_to_protein_aggregation__pathological _gates_from_protein_aggregation__pathological CRISPR-Cas Systems _gates_to_crispr_cas_systems

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