PathMap Literature Based Discovery Engine

Share your Discovery:

Guaranteed to find unpublished literature based discoveries.

Experiment #00000129

COPD Dietary Idea: According to PubMed literature, he following lunchtime meal plan provides nutrients needed for production and regulation of tryptophan and 3-IPA and may help reduce COPD flare-ups, while also providing mucosal support for clearance of debris from the lungs: -2x slices sourdough bread, lightly spread with extra virgin olive oil, garlic, and ginger, with 2x slices of cooked turkey and spinach, with nutritional yeast and hi-maize corn starch mixed into the EVOO (for mucosal system support) -a spinach-based salad with 1 Tbsp EVOO -3 oz pomegranate juice mixed with 3 oz cherry juice

Tryptophan _gates_from_tryptophan Gut Microbiota _gates_to_gut_microbiota _gates_from_gut_microbiota Indolepropionic Acid _gates_to_indolepropionic_acid IPA _gates_from_ipa Lung

View Results

Experiment #00000019

What is the role of 3-indolepropionic acid within the body, and what foods or nutrients may help replenish it if deficient?

Edible Grain _gates_from_edible_grain Clostridium sporogenes _gates_to_clostridium_sporogenes Gastrointestinal Microbiome _gates_from_gastrointestinal_microbiome 3-indolepropionic acid _gates_to_3_indolepropionic_acid _gates_from_3_indolepropionic_acid Signal Transduction

View Results

Experiment #00000013

Can BMAA, a known glutamate mimic, cause hyperexcited retinal ganglion cells and cause them to "misfire" corollary discharge?

Amino Acids, Diamino _gates_from_amino_acids__diamino Retina _gates_to_retina _gates_from_retina Corollary Discharge _gates_to_corollary_discharge NMDA receptors _gates_to_nmda_receptors NMDA receptor activation

View Results

Experiment #00000012

If a toxin with a thermodynamic affinity for Zinc GREATER THAN that of Glutamate AND LESS THAN that of RGNEF, under certain conditions a pathway exists wherein the toxin could shuttle synaptic retinal zinc to RGNEF, thus potentially ultimately resulting in the retinal TDP-43 proteinopathy seen in the retina post mortem in Sporadic Amyotrophic Lateral Sclerosis

Synaptic Zinc _gates_from_synaptic_zinc Receptors, Glutamate _gates_to_receptors__glutamate _gates_from_receptors__glutamate Zinc Dyshomeostasis in RGCs _gates_to_zinc_dyshomeostasis_in_rgcs _gates_from_zinc_dyshomeostasis_in_rgcs TDP-43 Proteinopathy _gates_to_tdp_43_proteinopathy

View Results