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PathMap Literature Based Discovery Engine
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Experiment #00000128
Discovered Hypothesis: Spermidine-mediated autophagic activation may serve as an upstream regulator of lysosomal TMEM175 activity to prevent proteinopathy in C9orf72-ALS/FTD models.
Spermidine
_gates_from_spermidine
Autophagy
_gates_to_autophagy
_gates_from_autophagy
Lysosomal Integrity
_gates_to_lysosomal_integrity
_gates_from_lysosomal_integrity
TMEM175
_gates_to_tmem175
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Reference Abstract
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Source: PubMed
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