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Experiment #00000015
Given that schizophrenia is characterized by a deficit in the attenuation of sensory input via corollary discharge, how might pathologically elevated RGC signaling—potentially caused by synaptic glutamate overflow without zinc modulation—interfere with the thalamic integration of extra-retinal CD signals to effectively reverse the predictive timing of visual stability?
SLC39A8 Protein
_gates_from_slc39a8_protein
Zinc Deficiency
_gates_to_zinc_deficiency
_gates_from_zinc_deficiency
Glutamic Acid
_gates_to_glutamic_acid
_gates_from_glutamic_acid
Thalamus
_gates_to_thalamus
_gates_from_thalamus
Models, Neurological
_gates_to_models__neurological
Retinal Ganglion Cells
_gates_from_retinal_ganglion_cells
Corollary Discharge
_gates_to_corollary_discharge
_gates_from_corollary_discharge
Perception
_gates_to_perception
Risk Factors
_gates_from_risk_factors
N-Methyl-D-Aspartate Receptor
_gates_to_n_methyl_d_aspartate_receptor
_gates_from_n_methyl_d_aspartate_receptor
Visual Perception
_gates_to_visual_perception
+17 more
View Results
Experiment #00000014
Under certain conditions, can hyperexcited retinal ganglion cells misfire corollary discharge(s) unexpectedly?
Oculomotor Motor Command
_gates_from_oculomotor_motor_command
Corollary Discharge
_gates_to_corollary_discharge
_gates_from_corollary_discharge
Sensory Processing, Sensory
_gates_to_sensory_processing__sensory
Retinal Ganglion Cells (RGCs)
_gates_from_retinal_ganglion_cells__rgcs_
Visual Perception
_gates_to_visual_perception
Retinal Ganglion Cells
_gates_from_retinal_ganglion_cells
Retinal Diseases
_gates_from_retinal_diseases
Hyperexcitability
_gates_to_hyperexcitability
_gates_from_hyperexcitability
Nonspecific
_gates_to_nonspecific
Neural Conduction
_gates_to_neural_conduction
_gates_from_neural_conduction
+13 more
View Results
Experiment #00000013
Can BMAA, a known glutamate mimic, cause hyperexcited retinal ganglion cells and cause them to "misfire" corollary discharge?
Amino Acids, Diamino
_gates_from_amino_acids__diamino
Retina
_gates_to_retina
_gates_from_retina
Corollary Discharge
_gates_to_corollary_discharge
NMDA receptors
_gates_to_nmda_receptors
NMDA receptor activation
_gates_from_nmda_receptor_activation
Reactive Oxygen Species
_gates_to_reactive_oxygen_species
_gates_from_reactive_oxygen_species
Cell Death
_gates_to_cell_death
_gates_from_cell_death
Receptors, N-Methyl-D-Aspartate
_gates_to_receptors__n_methyl_d_aspartate
_gates_from_receptors__n_methyl_d_aspartate
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
+12 more
View Results
Reference Abstract
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Source: PubMed
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