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Experiment #00000092
A Top-Down Mechanism for Sporadic ALS Initiated by Ocular Metal Dyshomeostasis and Retrograde Exosomal Transport along the Subcortical Visual Axis
Eye Diseases
_gates_from_eye_diseases
Retinal Diseases
_gates_to_retinal_diseases
_gates_from_retinal_diseases
Extracellular Vesicles
_gates_to_extracellular_vesicles
_gates_from_extracellular_vesicles
Motor Neurons
_gates_to_motor_neurons
View Results
Experiment #00000071
Do any recent non-proliferative diabetic retinopathy clinical trials reveal anything about Amyotrophic Lateral Sclerosis?
Diabetic Retinopathy
_gates_from_diabetic_retinopathy
ALS
_gates_to_als
Retinal Diseases
_gates_to_retinal_diseases
_gates_from_retinal_diseases
Neurodegenerative Diseases
_gates_to_neurodegenerative_diseases
_gates_from_neurodegenerative_diseases
Riluzole
_gates_to_riluzole
+2 more
View Results
Experiment #00000069
Keyword Analysis: diabetes; retinal diabetic neuropathy; ganglion cells; synapses; SPG302; tazbentetol; visual function; synaptic regeneration; neuroprotection; blindness; glaucoma
Glucose
_gates_from_glucose
Mitochondria
_gates_to_mitochondria
Mitochondrial Dysfunction
_gates_from_mitochondrial_dysfunction
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
SPG302 Treatment
_gates_from_spg302_treatment
Synapses
_gates_to_synapses
Hyperglycemia
_gates_from_hyperglycemia
Retinal Degeneration
_gates_to_retinal_degeneration
_gates_from_retinal_degeneration
_gates_from_synapses
Spastic Paraplegia, Hereditary
_gates_to_spastic_paraplegia__hereditary
Diabetes
_gates_from_diabetes
_gates_from_retinal_ganglion_cells
+13 more
View Results
Experiment #00000065
Does pathologically seeded TDP-43 exit the retina via anterograde axonal transport along the optic tract to midbrain hubs, enter the systemic circulation inside extracellular vesicles, and subsequently traffic into pancreatic beta-cells to accelerate type 2 diabetes phenotypes?
TAR DNA-Binding Protein 43
_gates_from_tar_dna_binding_protein_43
Extracellular Vesicles
_gates_to_extracellular_vesicles
Systemic circulating EVs
_gates_from_systemic_circulating_evs
Insulin-Secreting Cells
_gates_to_insulin_secreting_cells
Axonal Transport
_gates_to_axonal_transport
_gates_from_extracellular_vesicles
Diabetes Mellitus, Type 2
_gates_to_diabetes_mellitus__type_2
Pancreatic Beta-cells
_gates_to_pancreatic_beta_cells
Calcium Channels, L-Type
_gates_to_calcium_channels__l_type
+7 more
View Results
Experiment #00000055
If the RGNEF NF 242 Terminal loses its functional ability to agitate or compete with TDP-43, perhaps from misfolding or sequestration, could it cause the TDP-43 proteinopathy seen in the retina, post-mortem, in Sporadic Amyotrophic Lateral Sclerosis patients, if the RGNEF failures were localized in the retina?
RGNEF/NF242
_gates_from_rgnef_nf242
TDP-43
_gates_to_tdp_43
Rho Guanine Nucleotide Exchange Factor
_gates_from_rho_guanine_nucleotide_exchange_factor
TDP-43 Proteinopathies
_gates_to_tdp_43_proteinopathies
Amyotrophic Lateral Sclerosis
_gates_from_amyotrophic_lateral_sclerosis
Retina
_gates_to_retina
+2 more
View Results
Experiment #00000023
Does misfolded TDP43 affect Retinal Ganglion Cell STMN2 ability to repair in a similar way as what how it was shown to affect motor neurons with cryptic mis-splicing?
TDP-43 pathology
_gates_from_tdp_43_pathology
RNA Splicing
_gates_to_rna_splicing
_gates_from_rna_splicing
Stathmin 2
_gates_to_stathmin_2
Vitreous Body
_gates_to_vitreous_body
DNA-Binding Protein-43
_gates_from_dna_binding_protein_43
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
Cell Nucleus
_gates_from_cell_nucleus
_gates_from_stathmin_2
Axonal Degeneration
_gates_to_axonal_degeneration
Axons
_gates_to_axons
_gates_from_axons
+11 more
View Results
Experiment #00000016
Analyze the potential for zinc-binding competition between synaptic transporters (e.g., SLC39A8, ZnT3) and ALS-associated proteins (RGNEF, TDP-43) in the RGC-thalamic axis. Can this competition explain the coexistence of RGC excitotoxicity and STMN2 depletion in clinical samples?
TAR DNA-Binding Protein 43
_gates_from_tar_dna_binding_protein_43
Stathmin 2
_gates_to_stathmin_2
SLC39A8 protein, human
_gates_from_slc39a8_protein__human
Zinc
_gates_to_zinc
Excitotoxicity
_gates_from_excitotoxicity
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
Cation Transport Proteins
_gates_from_cation_transport_proteins
Transcription, Genetic
_gates_to_transcription__genetic
_gates_from_zinc
Binding Sites
_gates_to_binding_sites
_gates_to_tar_dna_binding_protein_43
+10 more
View Results
Experiment #00000015
Given that schizophrenia is characterized by a deficit in the attenuation of sensory input via corollary discharge, how might pathologically elevated RGC signaling—potentially caused by synaptic glutamate overflow without zinc modulation—interfere with the thalamic integration of extra-retinal CD signals to effectively reverse the predictive timing of visual stability?
SLC39A8 Protein
_gates_from_slc39a8_protein
Zinc Deficiency
_gates_to_zinc_deficiency
_gates_from_zinc_deficiency
Glutamic Acid
_gates_to_glutamic_acid
_gates_from_glutamic_acid
Thalamus
_gates_to_thalamus
_gates_from_thalamus
Models, Neurological
_gates_to_models__neurological
Retinal Ganglion Cells
_gates_from_retinal_ganglion_cells
Corollary Discharge
_gates_to_corollary_discharge
_gates_from_corollary_discharge
Perception
_gates_to_perception
Risk Factors
_gates_from_risk_factors
N-Methyl-D-Aspartate Receptor
_gates_to_n_methyl_d_aspartate_receptor
_gates_from_n_methyl_d_aspartate_receptor
Visual Perception
_gates_to_visual_perception
+17 more
View Results
Experiment #00000014
Under certain conditions, can hyperexcited retinal ganglion cells misfire corollary discharge(s) unexpectedly?
Oculomotor Motor Command
_gates_from_oculomotor_motor_command
Corollary Discharge
_gates_to_corollary_discharge
_gates_from_corollary_discharge
Sensory Processing, Sensory
_gates_to_sensory_processing__sensory
Retinal Ganglion Cells (RGCs)
_gates_from_retinal_ganglion_cells__rgcs_
Visual Perception
_gates_to_visual_perception
Retinal Ganglion Cells
_gates_from_retinal_ganglion_cells
Retinal Diseases
_gates_from_retinal_diseases
Hyperexcitability
_gates_to_hyperexcitability
_gates_from_hyperexcitability
Nonspecific
_gates_to_nonspecific
Neural Conduction
_gates_to_neural_conduction
_gates_from_neural_conduction
+13 more
View Results
Experiment #00000013
Can BMAA, a known glutamate mimic, cause hyperexcited retinal ganglion cells and cause them to "misfire" corollary discharge?
Amino Acids, Diamino
_gates_from_amino_acids__diamino
Retina
_gates_to_retina
_gates_from_retina
Corollary Discharge
_gates_to_corollary_discharge
NMDA receptors
_gates_to_nmda_receptors
NMDA receptor activation
_gates_from_nmda_receptor_activation
Reactive Oxygen Species
_gates_to_reactive_oxygen_species
_gates_from_reactive_oxygen_species
Cell Death
_gates_to_cell_death
_gates_from_cell_death
Receptors, N-Methyl-D-Aspartate
_gates_to_receptors__n_methyl_d_aspartate
_gates_from_receptors__n_methyl_d_aspartate
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
+12 more
View Results
Experiment #00000012
If a toxin with a thermodynamic affinity for Zinc GREATER THAN that of Glutamate AND LESS THAN that of RGNEF, under certain conditions a pathway exists wherein the toxin could shuttle synaptic retinal zinc to RGNEF, thus potentially ultimately resulting in the retinal TDP-43 proteinopathy seen in the retina post mortem in Sporadic Amyotrophic Lateral Sclerosis
Synaptic Zinc
_gates_from_synaptic_zinc
Receptors, Glutamate
_gates_to_receptors__glutamate
_gates_from_receptors__glutamate
Zinc Dyshomeostasis in RGCs
_gates_to_zinc_dyshomeostasis_in_rgcs
_gates_from_zinc_dyshomeostasis_in_rgcs
TDP-43 Proteinopathy
_gates_to_tdp_43_proteinopathy
Glutamate
_gates_to_glutamate
Zinc
_gates_from_zinc
DNA-Binding Proteins
_gates_to_dna_binding_proteins
Glutamate release
_gates_to_glutamate_release
Glutamate Excitotoxicity
_gates_from_glutamate_excitotoxicity
Retinal Diseases
_gates_to_retinal_diseases
RGNEF
_gates_from_rgnef
TDP-43
_gates_to_tdp_43
Toxins
_gates_from_toxins
_gates_to_zinc
+19 more
View Results
Experiment #00000005
What are the biomarker differences in TDP-43 proteinopathy within the cerebellum and retina when comparing Sporadic Amyotrophic Lateral Sclerosis and c9orf72 affected Familial Amyotrophic Lateral Sclerosis? Are there any mutually exclusive biomarkers that can be deduced?
C9orf72 expansion
_gates_from_c9orf72_expansion
Dipeptide Repeats
_gates_to_dipeptide_repeats
_gates_from_dipeptide_repeats
Microglia
_gates_to_microglia
C9orf72 Protein
_gates_from_c9orf72_protein
Cerebellum
_gates_to_cerebellum
Sporadic ALS
_gates_from_sporadic_als
TDP-43 Proteinopathies
_gates_to_tdp_43_proteinopathies
Inclusion Bodies
_gates_to_inclusion_bodies
Amyotrophic Lateral Sclerosis
_gates_from_amyotrophic_lateral_sclerosis
Peptides
_gates_to_peptides
C9orf72 Expansion
Atrophy
_gates_to_atrophy
TDP-43 Proteinopathy
_gates_from_tdp_43_proteinopathy
Retinal Degeneration
_gates_to_retinal_degeneration
C9orf72 hexanucleotide repeat
_gates_from_c9orf72_hexanucleotide_repeat
Transcriptome
_gates_to_transcriptome
TDP-43 pathology
_gates_from_tdp_43_pathology
Retina
_gates_to_retina
+26 more
View Results
Reference Abstract
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Source: PubMed
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