PathMap Literature Based Discovery Engine

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Experiment #00000089

Use of MBTPS1 inhibitors is a plausible strategy to prevent the terminal phase of nuclear death in specific cellular contexts.

Membrane-Bound Transcription Factor Peptidase, Site 1 _gates_from_membrane_bound_transcription_factor_peptidase__site_1 SREBP Activation _gates_to_srebp_activation _gates_from_srebp_activation Cellular Lipid Homeostasis _gates_to_cellular_lipid_homeostasis _gates_from_cellular_lipid_homeostasis Terminal Cell Death _gates_to_terminal_cell_death
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Experiment #00000088

Stabilizing the CREB3 tether via S1P/S2P protease inhibition represents a novel mechanism to prevent the terminal phase of neuronal death.

Endoplasmic Reticulum Stress _gates_from_endoplasmic_reticulum_stress Proteolysis _gates_to_proteolysis _gates_from_proteolysis Cyclic AMP-Response Element-Binding Protein _gates_to_cyclic_amp_response_element_binding_protein _gates_from_cyclic_amp_response_element_binding_protein Nuclear Envelope _gates_to_nuclear_envelope
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