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Experiment #00000143

Hypothesis: Dual-axis intranasal delivery of Spermidine-Modified Ginger-Derived Extracellular Vesicles (Spd-GDEVs) and SPG302 (Tazbentetol) via the cribriform plate may synergistically reverse motor neuron degeneration in sporadic ALS by simultaneously activating upstream proteostatic clearance networks and restoring downstream cytoarchitectural synaptic timing.

Administration, Intranasal _gates_from_administration__intranasal Autophagy _gates_to_autophagy SPG302 Application _gates_from_spg302_application Post-Synaptic Density _gates_to_post_synaptic_density

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Experiment #00000073

Can botulinum toxin A (BTX-A) be repurposed from cosmetic/spasticity applications in order to treat oculomotor palsy and have utilization with endoscopic endonasal approaches to skull base tumors to protect cranial nerves?

Botulinum Toxins, Type A _gates_from_botulinum_toxins__type_a Muscle Relaxation _gates_to_muscle_relaxation _gates_from_muscle_relaxation Neuroprotection _gates_to_neuroprotection Oculomotor Nerve Diseases _gates_from_oculomotor_nerve_diseases BTX-A

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Experiment #00000069

Keyword Analysis: diabetes; retinal diabetic neuropathy; ganglion cells; synapses; SPG302; tazbentetol; visual function; synaptic regeneration; neuroprotection; blindness; glaucoma

Glucose _gates_from_glucose Mitochondria _gates_to_mitochondria Mitochondrial Dysfunction _gates_from_mitochondrial_dysfunction Retinal Ganglion Cells _gates_to_retinal_ganglion_cells SPG302 Treatment _gates_from_spg302_treatment

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