PathMap Literature Based Discovery Engine

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Experiment #00000119

Hypothesis: Considering PubMed #41177462, Intranasally administered GDEVs, specifically spermidine-modified ginger extracellular vesicles, may offer a multi-target therapeutic strategy for C9orf72-associated ALS by crossing the blood-brain barrier via olfactory routes to potentially deliver gene-editing components, support axonal translation, restore STMN2 expression, and attenuate neuroinflammation.

Spermidine _gates_from_spermidine Olfactory Bulb _gates_to_olfactory_bulb Drug Delivery Systems _gates_from_drug_delivery_systems Stathmin 2 _gates_to_stathmin_2 Eukaryotic Initiation Factor-5A _gates_from_eukaryotic_initiation_factor_5a
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Experiment #00000038

Map the direct mechanical and axonal transport pathways connecting intranasal administration or trigeminal nerve delivery to the clearance of TDP-43 aggregates in sporadic ALS, and the delivery of CRISPR-Cas/ASO gene therapies targeting C9orf72 hexanucleotide repeat expansions in the cerebellum and brainstem.

Intranasal Route _gates_from_intranasal_route Blood-Brain Barrier _gates_to_blood_brain_barrier C9orf72 Protein _gates_to_c9orf72_protein _gates_from_c9orf72_protein Brain _gates_to_brain Intranasal Administration
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