PathMap Literature Based Discovery Engine

Share your Discovery:

Guaranteed to find unpublished literature based discoveries.

Clear Search

Experiment #00000120

Discovery: Considering PubMed #41177462 and PubMed #41231952, Spermidine-modified extracellular vesicles can mitigate ALS-related C9orf72 RAN translation by modulating the MARK2-eIF2α stress-sensing axis.

C9orf72 Protein _gates_from_c9orf72_protein EIF2A _gates_to_eif2a _gates_from_eif2a Nanoparticles _gates_to_nanoparticles
View Results
Experiment #00000038

Map the direct mechanical and axonal transport pathways connecting intranasal administration or trigeminal nerve delivery to the clearance of TDP-43 aggregates in sporadic ALS, and the delivery of CRISPR-Cas/ASO gene therapies targeting C9orf72 hexanucleotide repeat expansions in the cerebellum and brainstem.

Intranasal Route _gates_from_intranasal_route Blood-Brain Barrier _gates_to_blood_brain_barrier C9orf72 Protein _gates_to_c9orf72_protein _gates_from_c9orf72_protein Brain _gates_to_brain Intranasal Administration
View Results
Experiment #00000005

What are the biomarker differences in TDP-43 proteinopathy within the cerebellum and retina when comparing Sporadic Amyotrophic Lateral Sclerosis and c9orf72 affected Familial Amyotrophic Lateral Sclerosis? Are there any mutually exclusive biomarkers that can be deduced?

C9orf72 expansion _gates_from_c9orf72_expansion Dipeptide Repeats _gates_to_dipeptide_repeats _gates_from_dipeptide_repeats Microglia _gates_to_microglia C9orf72 Protein _gates_from_c9orf72_protein Cerebellum
View Results