PathMap Literature Based Discovery Engine

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Experiment #00000125

Discovery: Considering PubMed #37563705, #42012729, and #42541426, Spermidine is a known inducer of autophagy through EP300 inhibition and TFEB activation. Since TMEM106B amylofilaments induce lysosomal dysfunction, TFEB-driven restoration of lysosomal capacity would logically prevent the accumulation of these filaments.

Spermidine _gates_from_spermidine Transcription Factor EB _gates_to_transcription_factor_eb _gates_from_transcription_factor_eb Lysosomes _gates_to_lysosomes _gates_from_lysosomes TMEM106B protein _gates_to_tmem106b_protein
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Experiment #00000108

Restoration of efferocytosis is highly dependent on macrophage polarization states; M1 and M2 phenotypes can both contribute to resolution if metabolic cues are corrected.

Metabolic Signaling _gates_from_metabolic_signaling Efferocytic Capacity _gates_to_efferocytic_capacity PIEZO1 Protein _gates_from_piezo1_protein Calcium Influx _gates_to_calcium_influx _gates_from_calcium_influx Metabolic/Efferocytic Pathways
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Experiment #00000077

The use of lysosome-acidifying nanoparticles (AcNPs) could potentially be adapted to treat nanoplastic-induced lysosomal alkalization or membrane rigidification, as these nanoparticles act to restore the degradative capacity lost during environmental contaminant stress.

Nanoplastic exposure _gates_from_nanoplastic_exposure Lysosomes _gates_to_lysosomes _gates_from_lysosomes Autophagy _gates_to_autophagy Nanoparticles _gates_from_nanoparticles Hydrogen-Ion Concentration
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