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Experiment #00000055

If the RGNEF NF 242 Terminal loses its functional ability to agitate or compete with TDP-43, perhaps from misfolding or sequestration, could it cause the TDP-43 proteinopathy seen in the retina, post-mortem, in Sporadic Amyotrophic Lateral Sclerosis patients, if the RGNEF failures were localized in the retina?

RGNEF/NF242 _gates_from_rgnef_nf242 TDP-43 _gates_to_tdp_43 Rho Guanine Nucleotide Exchange Factor _gates_from_rho_guanine_nucleotide_exchange_factor TDP-43 Proteinopathies _gates_to_tdp_43_proteinopathies Amyotrophic Lateral Sclerosis _gates_from_amyotrophic_lateral_sclerosis

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