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Experiment #00000105
Gap Analysis: There is no PubMed data showing wet lab data or analysis of TPD-43 proteinopathy found (or not found) in the Cochlear, Spiral, or Scarpa's Ganglion of Amyotrophic Lateral Sclerosis patient data post mortem.
Amyotrophic Lateral Sclerosis
_gates_from_amyotrophic_lateral_sclerosis
TDP-43 proteinopathy
_gates_to_tdp_43_proteinopathy
_gates_from_tdp_43_proteinopathy
Spiral Ganglion
_gates_to_spiral_ganglion
Peripheral Nerves
_gates_from_peripheral_nerves
_gates_to_amyotrophic_lateral_sclerosis
Noise-Induced Hearing Loss
_gates_from_noise_induced_hearing_loss
DNA-Binding Proteins
_gates_to_dna_binding_proteins
_gates_from_dna_binding_proteins
Autophagy
_gates_to_autophagy
_gates_from_autophagy
Hearing Disorders
_gates_to_hearing_disorders
+10 more
View Results
Experiment #00000098
A 3x3 Evaluation Matrix of Biological Interactions of ARHGAP32, RGNEF (ARHGEF28), and TDP-43 in Neurodegenerative Disease found in PubMed Literature as of August 5, 2026
TDP-43 Proteinopathies
_gates_from_tdp_43_proteinopathies
RNA Splicing
_gates_to_rna_splicing
RGNEF (ARHGEF28)
_gates_from_rgnef__arhgef28_
TDP-43
_gates_to_tdp_43
View Results
Experiment #00000059
Amyotrophic lateral sclerosis; Biomarkers; Clinical trials; Neuron-derived extracellular vesicles; Neuropathology; Pharmacodynamic biomarkers; Surrogate endpoints; TDP-43
Disease Progression
_gates_from_disease_progression
Biological Markers
_gates_to_biological_markers
_gates_from_biological_markers
Proteomics
_gates_to_proteomics
Platform Data
_gates_from_platform_data
Patient Selection
_gates_to_patient_selection
TDP-43 pathology
_gates_from_tdp_43_pathology
ALS
_gates_to_als
_gates_from_als
Axonal Injury
_gates_to_axonal_injury
_gates_from_axonal_injury
+9 more
View Results
Experiment #00000055
If the RGNEF NF 242 Terminal loses its functional ability to agitate or compete with TDP-43, perhaps from misfolding or sequestration, could it cause the TDP-43 proteinopathy seen in the retina, post-mortem, in Sporadic Amyotrophic Lateral Sclerosis patients, if the RGNEF failures were localized in the retina?
RGNEF/NF242
_gates_from_rgnef_nf242
TDP-43
_gates_to_tdp_43
Rho Guanine Nucleotide Exchange Factor
_gates_from_rho_guanine_nucleotide_exchange_factor
TDP-43 Proteinopathies
_gates_to_tdp_43_proteinopathies
Amyotrophic Lateral Sclerosis
_gates_from_amyotrophic_lateral_sclerosis
Retina
_gates_to_retina
+2 more
View Results
Experiment #00000030
Can AI and single-cell RNA sequencing help map cryptic TDP-43 splicing errors in sporadic ALS to design BBB-penetrant CRISPR gene therapies before neurotoxicity begins?
Single-Cell Analysis
_gates_from_single_cell_analysis
RNA Splicing
_gates_to_rna_splicing
_gates_from_rna_splicing
Blood-Brain Barrier
_gates_to_blood_brain_barrier
_gates_from_blood_brain_barrier
Neurotoxicity Syndromes
_gates_to_neurotoxicity_syndromes
TDP-43 pathology
_gates_from_tdp_43_pathology
Exons
_gates_to_exons
_gates_from_exons
_gates_to_single_cell_analysis
Artificial Intelligence
_gates_to_artificial_intelligence
_gates_from_artificial_intelligence
DNA-Binding Proteins
_gates_from_dna_binding_proteins
Sequence Analysis, RNA
_gates_to_sequence_analysis__rna
CRISPR-Cas Systems
_gates_to_crispr_cas_systems
+15 more
View Results
Experiment #00000024
If RGNEF fails agitate and regulate TDP-43 at the RGNEF NF242 Terminal, does this cause TDP-43 propteinopathy?
Protein Interaction Mapping
_gates_from_protein_interaction_mapping
RNA Stability
_gates_to_rna_stability
Peptide Fragments
_gates_from_peptide_fragments
RNA Recognition Motif
_gates_to_rna_recognition_motif
Metabolic stress
_gates_from_metabolic_stress
Micronuclei
_gates_to_micronuclei
Protein Aggregates
_gates_from_protein_aggregates
Neurofilament Proteins
_gates_to_neurofilament_proteins
NF242 Fragment
_gates_from_nf242_fragment
TDP-43 Proteinopathies
_gates_to_tdp_43_proteinopathies
RNA Sequestration
_gates_to_rna_sequestration
+12 more
View Results
Experiment #00000023
Does misfolded TDP43 affect Retinal Ganglion Cell STMN2 ability to repair in a similar way as what how it was shown to affect motor neurons with cryptic mis-splicing?
TDP-43 pathology
_gates_from_tdp_43_pathology
RNA Splicing
_gates_to_rna_splicing
_gates_from_rna_splicing
Stathmin 2
_gates_to_stathmin_2
Vitreous Body
_gates_to_vitreous_body
DNA-Binding Protein-43
_gates_from_dna_binding_protein_43
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
Cell Nucleus
_gates_from_cell_nucleus
_gates_from_stathmin_2
Axonal Degeneration
_gates_to_axonal_degeneration
Axons
_gates_to_axons
_gates_from_axons
+11 more
View Results
Experiment #00000022
Do Bulbar Amyotrophic Lateral Sclerosis patients have TDP43 proteinopathy in cochlear/spiral ganglion post mortem?
Ubiquilin-1
_gates_from_ubiquilin_1
TDP-43 Proteinopathies
_gates_to_tdp_43_proteinopathies
_gates_from_tdp_43_proteinopathies
Amyotrophic Lateral Sclerosis
_gates_to_amyotrophic_lateral_sclerosis
Disease Models, Animal
_gates_from_disease_models__animal
Cochlear Nucleus
_gates_to_cochlear_nucleus
_gates_from_cochlear_nucleus
TDP-43 proteinopathy
_gates_to_tdp_43_proteinopathy
_gates_from_amyotrophic_lateral_sclerosis
_gates_from_tdp_43_proteinopathy
Spiral Ganglion Neurons
_gates_to_spiral_ganglion_neurons
+8 more
View Results
Experiment #00000012
If a toxin with a thermodynamic affinity for Zinc GREATER THAN that of Glutamate AND LESS THAN that of RGNEF, under certain conditions a pathway exists wherein the toxin could shuttle synaptic retinal zinc to RGNEF, thus potentially ultimately resulting in the retinal TDP-43 proteinopathy seen in the retina post mortem in Sporadic Amyotrophic Lateral Sclerosis
Synaptic Zinc
_gates_from_synaptic_zinc
Receptors, Glutamate
_gates_to_receptors__glutamate
_gates_from_receptors__glutamate
Zinc Dyshomeostasis in RGCs
_gates_to_zinc_dyshomeostasis_in_rgcs
_gates_from_zinc_dyshomeostasis_in_rgcs
TDP-43 Proteinopathy
_gates_to_tdp_43_proteinopathy
Glutamate
_gates_to_glutamate
Zinc
_gates_from_zinc
DNA-Binding Proteins
_gates_to_dna_binding_proteins
Glutamate release
_gates_to_glutamate_release
Glutamate Excitotoxicity
_gates_from_glutamate_excitotoxicity
Retinal Diseases
_gates_to_retinal_diseases
RGNEF
_gates_from_rgnef
TDP-43
_gates_to_tdp_43
Toxins
_gates_from_toxins
_gates_to_zinc
+19 more
View Results
Experiment #00000005
What are the biomarker differences in TDP-43 proteinopathy within the cerebellum and retina when comparing Sporadic Amyotrophic Lateral Sclerosis and c9orf72 affected Familial Amyotrophic Lateral Sclerosis? Are there any mutually exclusive biomarkers that can be deduced?
C9orf72 expansion
_gates_from_c9orf72_expansion
Dipeptide Repeats
_gates_to_dipeptide_repeats
_gates_from_dipeptide_repeats
Microglia
_gates_to_microglia
C9orf72 Protein
_gates_from_c9orf72_protein
Cerebellum
_gates_to_cerebellum
Sporadic ALS
_gates_from_sporadic_als
TDP-43 Proteinopathies
_gates_to_tdp_43_proteinopathies
Inclusion Bodies
_gates_to_inclusion_bodies
Amyotrophic Lateral Sclerosis
_gates_from_amyotrophic_lateral_sclerosis
Peptides
_gates_to_peptides
C9orf72 Expansion
Atrophy
_gates_to_atrophy
TDP-43 Proteinopathy
_gates_from_tdp_43_proteinopathy
Retinal Degeneration
_gates_to_retinal_degeneration
C9orf72 hexanucleotide repeat
_gates_from_c9orf72_hexanucleotide_repeat
Transcriptome
_gates_to_transcriptome
TDP-43 pathology
_gates_from_tdp_43_pathology
Retina
_gates_to_retina
+26 more
View Results
Reference Abstract
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Source: PubMed
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