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Experiment #00000078
Activated STING triggers inflammatory cytokines that directly drive astrocytic AQP4 depolarization; dampening this pathway restores the perivascular endfoot morphology necessary for glymphatic flow.
Metabolic Stress
_gates_from_metabolic_stress
DNA, Mitochondrial
_gates_to_dna__mitochondrial
_gates_from_dna__mitochondrial
cGAS-STING Pathway
_gates_to_cgas_sting_pathway
_gates_from_cgas_sting_pathway
Neuroinflammation
_gates_to_neuroinflammation
_gates_from_neuroinflammation
Aquaporin 4
_gates_to_aquaporin_4
_gates_from_aquaporin_4
Glymphatic System
_gates_to_glymphatic_system
DNA Sensing
_gates_from_dna_sensing
STING Antagonist
_gates_from_sting_antagonist
Cellular Stress
_gates_from_cellular_stress
STING Agonist
_gates_to_sting_agonist
cGAS-STING Activation
_gates_from_cgas_sting_activation
Cellular Senescence
_gates_to_cellular_senescence
Inflammatory Signaling
_gates_from_inflammatory_signaling
+20 more
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Reference Abstract
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Source: PubMed
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