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Experiment #00000145

The use of cGAS-STING inhibitors (e.g., H151) and senotherapeutics, currently being explored for cancer and neurodegeneration, may provide a novel pharmacological path for rescuing sarcopenic muscle function.

Mitochondrial dysfunction _gates_from_mitochondrial_dysfunction DNA, Mitochondrial _gates_to_dna__mitochondrial _gates_from_dna__mitochondrial cGAS-STING signaling _gates_to_cgas_sting_signaling _gates_from_cgas_sting_signaling Cellular Senescence _gates_to_cellular_senescence
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Experiment #00000078

Activated STING triggers inflammatory cytokines that directly drive astrocytic AQP4 depolarization; dampening this pathway restores the perivascular endfoot morphology necessary for glymphatic flow.

Metabolic Stress _gates_from_metabolic_stress DNA, Mitochondrial _gates_to_dna__mitochondrial _gates_from_dna__mitochondrial cGAS-STING Pathway _gates_to_cgas_sting_pathway _gates_from_cgas_sting_pathway Neuroinflammation _gates_to_neuroinflammation
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Experiment #00000047

Does blast-induced mild traumatic brain injury (mTBI) drive progressive tau/TDP-43 seeding by disrupting astrocytic AQP4 glymphatic clearance and activating microglial cGAS-STING neuroinflammation? #mTBI #Glymphatic #cGASSTING

Blast Injuries _gates_from_blast_injuries Aquaporin 4 _gates_to_aquaporin_4 _gates_from_aquaporin_4 Glymphatic System _gates_to_glymphatic_system _gates_from_glymphatic_system Protein Aggregates _gates_to_protein_aggregates
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