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Experiment #00000111
Identify specific patterns of TDP-43 proteinopathy induced cryptic mis-splicing of STMN2 and other "cryptic mis-splicing" patterns found within PubMed Literature, 2026.
DNA-Binding Protein 43
_gates_from_dna_binding_protein_43
Exons
_gates_to_exons
_gates_from_exons
Protein Deficiency
_gates_to_protein_deficiency
Functional Protein Loss
_gates_from_functional_protein_loss
Neurodegeneration
_gates_to_neurodegeneration
Peptides
_gates_to_peptides
_gates_from_peptides
Synaptic Transmission
_gates_to_synaptic_transmission
+6 more
View Results
Experiment #00000080
Prenatal iron deficiency (ID) exacerbates the risk of sudden infant death syndrome (SIDS) by modulating the expression of the hypothalamic orexin system, impairing homeostatic arousal mechanisms during hypoxia.
Anemia, Iron-Deficiency
_gates_from_anemia__iron_deficiency
Hypothalamic-Hypophyseal System
_gates_to_hypothalamic_hypophyseal_system
_gates_from_hypothalamic_hypophyseal_system
Sudden Infant Death
_gates_to_sudden_infant_death
_gates_from_sudden_infant_death
Orexins
_gates_to_orexins
Neurodevelopmental Disorders
_gates_to_neurodevelopmental_disorders
_gates_from_neurodevelopmental_disorders
_gates_from_orexins
Arousal
_gates_to_arousal
+6 more
View Results
Experiment #00000016
Analyze the potential for zinc-binding competition between synaptic transporters (e.g., SLC39A8, ZnT3) and ALS-associated proteins (RGNEF, TDP-43) in the RGC-thalamic axis. Can this competition explain the coexistence of RGC excitotoxicity and STMN2 depletion in clinical samples?
TAR DNA-Binding Protein 43
_gates_from_tar_dna_binding_protein_43
Stathmin 2
_gates_to_stathmin_2
SLC39A8 protein, human
_gates_from_slc39a8_protein__human
Zinc
_gates_to_zinc
Excitotoxicity
_gates_from_excitotoxicity
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
Cation Transport Proteins
_gates_from_cation_transport_proteins
Transcription, Genetic
_gates_to_transcription__genetic
_gates_from_zinc
Binding Sites
_gates_to_binding_sites
_gates_to_tar_dna_binding_protein_43
+10 more
View Results
Experiment #00000015
Given that schizophrenia is characterized by a deficit in the attenuation of sensory input via corollary discharge, how might pathologically elevated RGC signaling—potentially caused by synaptic glutamate overflow without zinc modulation—interfere with the thalamic integration of extra-retinal CD signals to effectively reverse the predictive timing of visual stability?
SLC39A8 Protein
_gates_from_slc39a8_protein
Zinc Deficiency
_gates_to_zinc_deficiency
_gates_from_zinc_deficiency
Glutamic Acid
_gates_to_glutamic_acid
_gates_from_glutamic_acid
Thalamus
_gates_to_thalamus
_gates_from_thalamus
Models, Neurological
_gates_to_models__neurological
Retinal Ganglion Cells
_gates_from_retinal_ganglion_cells
Corollary Discharge
_gates_to_corollary_discharge
_gates_from_corollary_discharge
Perception
_gates_to_perception
Risk Factors
_gates_from_risk_factors
N-Methyl-D-Aspartate Receptor
_gates_to_n_methyl_d_aspartate_receptor
_gates_from_n_methyl_d_aspartate_receptor
Visual Perception
_gates_to_visual_perception
+17 more
View Results
Experiment #00000012
If a toxin with a thermodynamic affinity for Zinc GREATER THAN that of Glutamate AND LESS THAN that of RGNEF, under certain conditions a pathway exists wherein the toxin could shuttle synaptic retinal zinc to RGNEF, thus potentially ultimately resulting in the retinal TDP-43 proteinopathy seen in the retina post mortem in Sporadic Amyotrophic Lateral Sclerosis
Synaptic Zinc
_gates_from_synaptic_zinc
Receptors, Glutamate
_gates_to_receptors__glutamate
_gates_from_receptors__glutamate
Zinc Dyshomeostasis in RGCs
_gates_to_zinc_dyshomeostasis_in_rgcs
_gates_from_zinc_dyshomeostasis_in_rgcs
TDP-43 Proteinopathy
_gates_to_tdp_43_proteinopathy
Glutamate
_gates_to_glutamate
Zinc
_gates_from_zinc
DNA-Binding Proteins
_gates_to_dna_binding_proteins
Glutamate release
_gates_to_glutamate_release
Glutamate Excitotoxicity
_gates_from_glutamate_excitotoxicity
Retinal Diseases
_gates_to_retinal_diseases
RGNEF
_gates_from_rgnef
TDP-43
_gates_to_tdp_43
Toxins
_gates_from_toxins
_gates_to_zinc
+19 more
View Results
Reference Abstract
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Source: PubMed
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