PathMap Literature Based Discovery Engine

Share your Discovery:

Guaranteed to find unpublished literature based discoveries.

Clear Search

Experiment #00000076

Nanoplastic-induced lysosomal membrane remodeling may sequester WDR44, creating a 'hotspot' for α-synuclein aggregation initiation.

Nanoplastics internalization _gates_from_nanoplastics_internalization Lysosomal accumulation _gates_to_lysosomal_accumulation _gates_from_lysosomal_accumulation Lysosomal Membranes _gates_to_lysosomal_membranes WDR44 _gates_from_wdr44 WDR44 protein
View Results
Experiment #00000075

Polystyrene nanoplastics (PS-NPs) may act as a scaffold for the recruitment and accumulation of WDR44 at the lysosomal membrane, thereby accelerating the de novo aggregation of alpha-synuclein in the early stages of PD.

Nanoplastic exposure _gates_from_nanoplastic_exposure Lysosomal Storage Diseases _gates_to_lysosomal_storage_diseases _gates_from_lysosomal_storage_diseases alpha-Synuclein _gates_to_alpha_synuclein WDR44 _gates_from_wdr44 Protein Aggregates
View Results
Experiment #00000004

Can the identified lysosomal-targeted acidic nanoparticles (AcNPs) or specific small-molecule chaperones effectively reverse established alpha-synuclein aggregation in chronic exposure models, and do they provide neuroprotection against subsequent environmental pollutant insults?

Lysosomal Storage Diseases _gates_from_lysosomal_storage_diseases alpha-Synuclein _gates_to_alpha_synuclein Alpha-synuclein aggregation _gates_from_alpha_synuclein_aggregation Molecular Chaperones _gates_to_molecular_chaperones Lysosomes _gates_from_lysosomes
View Results
Experiment #00000003

Does long-term microplastic or bisphenol exposure act as a catalyst for alpha-synucleitin aggregation in Parkinson's disease by disrupting lysosomal membrane permeabilization?

Environmental Exposure _gates_from_environmental_exposure Endolysosomes _gates_to_endolysosomes _gates_from_endolysosomes Lysosomal Membranes _gates_to_lysosomal_membranes _gates_from_lysosomal_membranes Autophagy _gates_to_autophagy
View Results