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Experiment #00000131

Premise: Environmental metals, though present in many Amyotrophic Lateral Sclerosis anomalous clusters, are debated regarding causality within geographic epistemological data. Hypothesis: If plant derived extracellular vesicles (PDEVs) aerosolized with environmental metals, they could potentially bypass the blood brain barrier via the cribriform plate area. Given this potential method of delivery, environmental metals cannot be ruled out as causal in sporadic ALS until PDEV delivery of the metals is tested in wet lab experiments, but may potentially explain the condounding data.

Environmental Pollutants _gates_from_environmental_pollutants PDEV association _gates_to_pdev_association _gates_from_pdev_association Nose-to-Brain Delivery _gates_to_nose_to_brain_delivery _gates_from_nose_to_brain_delivery Brain Diseases _gates_to_brain_diseases
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Experiment #00000118

Environmental plant-derived extracellular vesicles (such as those from pollen or agricultural dust) may act as stealth vectors via nasal-olfactory pathways, potentially delivering environmental toxins or pathogenic RNAs that bypass the BBB and trigger neurodegenerative pathologies, such as Amyotrophic Lateral Sclerosis.

Olfactory Pathways _gates_from_olfactory_pathways Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles Biological Factors _gates_to_biological_factors _gates_from_biological_factors Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis
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Experiment #00000004

Can the identified lysosomal-targeted acidic nanoparticles (AcNPs) or specific small-molecule chaperones effectively reverse established alpha-synuclein aggregation in chronic exposure models, and do they provide neuroprotection against subsequent environmental pollutant insults?

Lysosomal Storage Diseases _gates_from_lysosomal_storage_diseases alpha-Synuclein _gates_to_alpha_synuclein Alpha-synuclein aggregation _gates_from_alpha_synuclein_aggregation Molecular Chaperones _gates_to_molecular_chaperones Lysosomes _gates_from_lysosomes
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Experiment #00000003

Does long-term microplastic or bisphenol exposure act as a catalyst for alpha-synucleitin aggregation in Parkinson's disease by disrupting lysosomal membrane permeabilization?

Environmental Exposure _gates_from_environmental_exposure Endolysosomes _gates_to_endolysosomes _gates_from_endolysosomes Lysosomal Membranes _gates_to_lysosomal_membranes _gates_from_lysosomal_membranes Autophagy _gates_to_autophagy
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