PathMap Literature Based Discovery Engine

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Experiment #00000130

Targeted alteration of the oral microbiome via a single polyphenol- and fiber-dense meal plan creates an immediate shift in the microbial composition of involuntary nocturnal microaspiration droplets. Upon entry into the lower respiratory tract, this eubiotic bacterial influx acts as an acute molecular signal that rapidly modulates microglia reactivity and neuroinflammation via the lung-brain axis, bypassing systemic colonic metabolite transport.

Dietary modification _gates_from_dietary_modification Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Respiratory Aspiration _gates_to_respiratory_aspiration _gates_from_respiratory_aspiration Microglia _gates_to_microglia

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Experiment #00000129

COPD Dietary Idea: According to PubMed literature, he following lunchtime meal plan provides nutrients needed for production and regulation of tryptophan and 3-IPA and may help reduce COPD flare-ups, while also providing mucosal support for clearance of debris from the lungs: -2x slices sourdough bread, lightly spread with extra virgin olive oil, garlic, and ginger, with 2x slices of cooked turkey and spinach, with nutritional yeast and hi-maize corn starch mixed into the EVOO (for mucosal system support) -a spinach-based salad with 1 Tbsp EVOO -3 oz pomegranate juice mixed with 3 oz cherry juice

Tryptophan _gates_from_tryptophan Gut Microbiota _gates_to_gut_microbiota _gates_from_gut_microbiota Indolepropionic Acid _gates_to_indolepropionic_acid IPA _gates_from_ipa Lung

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Experiment #00000113

COPD Related Alveoli and Lung Microbiome Axis Restoration Hypothesis: The use of 'pre-digested' (fermented) plant-based nutritional additives as a means to circumvent the bioavailability paradox in patients with gut dysbiosis, effectively using botanical matrices as drug-delivery vehicles. Nucleotide supplementation may enhance the ability of A. muciniphila to modulate gut mucosal barrier integrity in hyperuricemia patients. Akkermansia possesses unique enzymes (β-N-acetylhexosaminidases) that allow it to colonize the mucosal layer and participate in mucin degradation.

Fermentation _gates_from_fermentation Bioavailability _gates_to_bioavailability _gates_from_bioavailability Homeostasis _gates_to_homeostasis Plant Preparations _gates_from_plant_preparations Probiotics

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