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Experiment #00000113

COPD Related Alveoli and Lung Microbiome Axis Restoration Hypothesis: The use of 'pre-digested' (fermented) plant-based nutritional additives as a means to circumvent the bioavailability paradox in patients with gut dysbiosis, effectively using botanical matrices as drug-delivery vehicles. Nucleotide supplementation may enhance the ability of A. muciniphila to modulate gut mucosal barrier integrity in hyperuricemia patients. *Akkermansia* possesses unique enzymes (β-N-acetylhexosaminidases) that allow it to colonize the mucosal layer and participate in mucin degradation.

Fermentation _gates_from_fermentation Bioavailability _gates_to_bioavailability _gates_from_bioavailability Homeostasis _gates_to_homeostasis Plant Preparations _gates_from_plant_preparations Probiotics
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Experiment #00000094

Hypothesis: If studied by scientists, pickled ginseng may be found to have therapeutic use in treating gut dysbiosis, potentially acting as a pathway to reduce neuroinflammation in some neurodegenerative diseases such as ALS.

Ginseng _gates_from_ginseng Gut Microbiota _gates_to_gut_microbiota _gates_from_gut_microbiota Neuroinflammation _gates_to_neuroinflammation _gates_from_neuroinflammation Neurodegenerative Diseases _gates_to_neurodegenerative_diseases
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Experiment #00000093

What is the core mechanism that Almased uses to improve metabolism and liver function and can the mechanism be repurposed as a therapeutic in neurodegenerative disease via the gut-brain axis?

Dietary Therapy _gates_from_dietary_therapy Intestinal Mucosa _gates_to_intestinal_mucosa _gates_from_intestinal_mucosa Inflammation Mediators _gates_to_inflammation_mediators Pro-inflammatory mediators _gates_from_pro_inflammatory_mediators Gastrointestinal Microbiome
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Experiment #00000083

Dietary strategy: High amylose maize starch may be identified as a non-invasive tool to improve outcomes in TBI, and potentially hypoxic neurovascular damage, suggesting it could be repurposed for high-altitude workers or elderly patients with cognitive frailty.

High Amylose Maize Starch (HAMS) _gates_from_high_amylose_maize_starch__hams_ Fatty Acids, Volatile _gates_to_fatty_acids__volatile _gates_from_fatty_acids__volatile Blood-Brain Barrier _gates_to_blood_brain_barrier _gates_from_blood_brain_barrier Brain Injuries, Traumatic _gates_to_brain_injuries__traumatic
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Experiment #00000081

How does the gut microbiome modulate inflammation?

Microbial Dysbiosis _gates_from_microbial_dysbiosis Permeability _gates_to_permeability _gates_from_permeability Bacterial Translocation _gates_to_bacterial_translocation _gates_from_bacterial_translocation Toll-Like Receptor 4 _gates_to_toll_like_receptor_4
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Experiment #00000054

What dietary habits are beneficial towards reducing excess/harmful tyramine in order to improve liver and gut health?

Dietary Proteins _gates_from_dietary_proteins Aromatic-L-Amino-Acid Decarboxylases _gates_to_aromatic_l_amino_acid_decarboxylases _gates_from_aromatic_l_amino_acid_decarboxylases Tyramine _gates_to_tyramine _gates_from_tyramine Gastrointestinal Diseases _gates_to_gastrointestinal_diseases
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Experiment #00000052

Can fatty liver disease be treated in order to restore gut health?

MASLD pathophysiology _gates_from_masld_pathophysiology Gastrointestinal Microbiome _gates_to_gastrointestinal_microbiome _gates_from_gastrointestinal_microbiome Farnesoid X-Activated Receptor _gates_to_farnesoid_x_activated_receptor _gates_from_farnesoid_x_activated_receptor Intestinal Mucosa _gates_to_intestinal_mucosa
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Experiment #00000027

How does eating legumes and vegetables help restore gut-brain axis homeostasis?

Vegetables _gates_from_vegetables Gastrointestinal Microbiome _gates_to_gastrointestinal_microbiome _gates_from_gastrointestinal_microbiome Inflammation _gates_to_inflammation _gates_from_inflammation Neuroprotection _gates_to_neuroprotection
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Experiment #00000020

Does age-related gut dysbiosis drive sarcopenia by activating the cGAS-STING inflammatory pathway to suppress satellite cell renewal?

Gastrointestinal Microbiome _gates_from_gastrointestinal_microbiome Inflammation _gates_to_inflammation _gates_from_inflammation cGAS-STING Pathway Activation _gates_to_cgas_sting_pathway_activation _gates_from_cgas_sting_pathway_activation Satellite Cells _gates_to_satellite_cells
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Experiment #00000019

What is the role of 3-indolepropionic acid within the body, and what foods or nutrients may help replenish it if deficient?

Edible Grain _gates_from_edible_grain Clostridium sporogenes _gates_to_clostridium_sporogenes Gastrointestinal Microbiome _gates_from_gastrointestinal_microbiome 3-indolepropionic acid _gates_to_3_indolepropionic_acid _gates_from_3_indolepropionic_acid Signal Transduction
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