PathMap Literature Based Discovery Engine
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Why do seemingly perfectly healthy infants suddenly pass away in their sleep?


What types of infections might cause a high C-Reactive Protein result?


Amyotrophic Lateral Sclerosis breakthrough updates as of July 2026


The ALS-T2D comorbidity is driven by a bidirectional, exosome-mediated proteostatic collapse. Peripheral tissues (muscle, pancreas) dictate CNS TDP-43 stability via exosomal miRNAs (miR-126a-5p) and glucose-dependent modifications (O-GlcNAcylation). Conversely, pharmacological activation of ubiquitin-peptidases (e.g., Acarbose targeting USP46) or restitution of glycolytic cofactors (F2,6BP) represent novel, cross-disciplinary therapeutic targets capable of halting systemic proteinopathy.


Diabetes Mellitus, Type 2
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Extracellular Vesicles
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DNA-Binding Proteins
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Amyotrophic Lateral Sclerosis
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How does knitting help improve mental health?


What is the biological/molecular pathway that causes sarcopenia with the scope of COPD? Do the quads serve as a pathological progression indicator?


Pulmonary Disease, Chronic Obstructive
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Systemic Inflammatory Response Syndrome
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Signal Transduction
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Muscular Atrophy
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Can inhaled COVID-19 vaccinations be used to help treat COPD?


Pulmonary Disease, Chronic Obstructive
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Administration, Inhalation
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Immunity, Mucosal
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Mucous Membrane
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_gates_from_mucous_membrane
Why are frontotemporal dementia and c9orf72 ALS considered different diseases if they are both driven by the same abnormal expansion of a GGGGCC (G₄C₂) sequence in the first intron of the C9orf72 gene? Is it logical to think that CRISPR therapeutics for FTD potentially be used for ALS as well?


C9orf72 expansion
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Gene Expression Regulation
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_gates_from_gene_expression_regulation
Protein Aggregation, Pathological
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_gates_from_protein_aggregation__pathological
CRISPR-Cas Systems
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Can smoking cigarettes cause dysbiosis?


How does the gut-brain axis play a role in Alzheimer's Disease? Is there a potential link for gut-brain axis for other neurological disorders such as Amyotrophic Lateral Sclerosis?


Dysbiosis
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Intestinal Permeability
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_gates_from_intestinal_permeability
Systemic Inflammatory Response Syndrome
_gates_to_systemic_inflammatory_response_syndrome
_gates_from_systemic_inflammatory_response_syndrome
Neuroinflammation
_gates_to_neuroinflammation
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