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Experiment #00000098

A 3x3 Evaluation Matrix of Biological Interactions of ARHGAP32, RGNEF (ARHGEF28), and TDP-43 in Neurodegenerative Disease found in PubMed Literature as of August 5, 2026

TDP-43 Proteinopathies _gates_from_tdp_43_proteinopathies RNA Splicing _gates_to_rna_splicing RGNEF (ARHGEF28) _gates_from_rgnef__arhgef28_ TDP-43 _gates_to_tdp_43
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Experiment #00000097

Evaluation of Known Roles of ARHGAP32, RGNEF (ARHGEF28), and TDP-43 in Neurodegenerative Disease found in PubMed Literature as of August 5, 2026

DNA-Binding Proteins _gates_from_dna_binding_proteins RNA Splicing _gates_to_rna_splicing _gates_from_rna_splicing Neuronal Plasticity _gates_to_neuronal_plasticity Synaptic Transmission _gates_to_synaptic_transmission Neuronal Dysfunction
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Experiment #00000055

If the RGNEF NF 242 Terminal loses its functional ability to agitate or compete with TDP-43, perhaps from misfolding or sequestration, could it cause the TDP-43 proteinopathy seen in the retina, post-mortem, in Sporadic Amyotrophic Lateral Sclerosis patients, if the RGNEF failures were localized in the retina?

RGNEF/NF242 _gates_from_rgnef_nf242 TDP-43 _gates_to_tdp_43 Rho Guanine Nucleotide Exchange Factor _gates_from_rho_guanine_nucleotide_exchange_factor TDP-43 Proteinopathies _gates_to_tdp_43_proteinopathies Amyotrophic Lateral Sclerosis _gates_from_amyotrophic_lateral_sclerosis
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Experiment #00000039

What is the current evidence for RGNEF (ARHGEF28) functioning as a primary upstream regulator of axonal transport and TDP-43 homeostasis in ALS, and how does the failure of this 'terminal tether' initiate the pathological continuum compared to downstream protein aggregation?

Metabolic Stress _gates_from_metabolic_stress Protein Aggregation _gates_to_protein_aggregation _gates_from_protein_aggregation RNA Metabolism _gates_to_rna_metabolism _gates_from_rna_metabolism Axonal Transport _gates_to_axonal_transport
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Experiment #00000024

If RGNEF fails agitate and regulate TDP-43 at the RGNEF NF242 Terminal, does this cause TDP-43 propteinopathy?

Protein Interaction Mapping _gates_from_protein_interaction_mapping RNA Stability _gates_to_rna_stability Peptide Fragments _gates_from_peptide_fragments RNA Recognition Motif _gates_to_rna_recognition_motif Metabolic stress _gates_from_metabolic_stress
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Experiment #00000016

Analyze the potential for zinc-binding competition between synaptic transporters (e.g., SLC39A8, ZnT3) and ALS-associated proteins (RGNEF, TDP-43) in the RGC-thalamic axis. Can this competition explain the coexistence of RGC excitotoxicity and STMN2 depletion in clinical samples?

TAR DNA-Binding Protein 43 _gates_from_tar_dna_binding_protein_43 Stathmin 2 _gates_to_stathmin_2 SLC39A8 protein, human _gates_from_slc39a8_protein__human Zinc _gates_to_zinc Excitotoxicity _gates_from_excitotoxicity
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Experiment #00000012

If a toxin with a thermodynamic affinity for Zinc GREATER THAN that of Glutamate AND LESS THAN that of RGNEF, under certain conditions a pathway exists wherein the toxin could shuttle synaptic retinal zinc to RGNEF, thus potentially ultimately resulting in the retinal TDP-43 proteinopathy seen in the retina post mortem in Sporadic Amyotrophic Lateral Sclerosis

Synaptic Zinc _gates_from_synaptic_zinc Receptors, Glutamate _gates_to_receptors__glutamate _gates_from_receptors__glutamate Zinc Dyshomeostasis in RGCs _gates_to_zinc_dyshomeostasis_in_rgcs _gates_from_zinc_dyshomeostasis_in_rgcs TDP-43 Proteinopathy _gates_to_tdp_43_proteinopathy
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