PathMap Literature Based Discovery Engine

Share your Discovery:

Guaranteed to find unpublished literature based discoveries.

Clear Search

Experiment #00000136

Borneol-mediated membrane permeability can enhance the therapeutic delivery of plant-derived extracellular vesicles to deep-seated endometriotic lesions, bridging the gap between existing delivery enhancements for CNS ischemia and local anti-fibrotic treatments.

Borneol _gates_from_borneol Drug Delivery Systems _gates_to_drug_delivery_systems _gates_from_drug_delivery_systems Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles Fibrosis _gates_to_fibrosis
View Results
Experiment #00000135

Discovery: Vaginal delivery of Hyaluronic Acid-modified Ginger Extracellular Vesicles (HA-GDEVs) co-functionalized with borneol may penetrate fibrotic endometriotic lesions via CD44 targeting, delivering anti-angiogenic payloads to induce lesion regression without systemic hormonal toxicity.

Extracellular Vesicles _gates_from_extracellular_vesicles Drug Delivery Systems _gates_to_drug_delivery_systems _gates_from_drug_delivery_systems Remission Induction _gates_to_remission_induction _gates_from_remission_induction Drug-Related Side Effects and Adverse Reactions _gates_to_drug_related_side_effects_and_adverse_reactions
View Results
Experiment #00000134

Hypothesis: Intraperitoneal administration of a thermoresponsive hydrogel loaded with borneol-functionalized ginger derived extracellular vesicles (Moxibustion-Modified GDEVs) may provide a sustained, localized delivery to ovarian tumors, potentially enhancing deep tissue penetration and inducing apoptosis without systemic chemotoxicity.

Extracellular Vesicles _gates_from_extracellular_vesicles Nanocarriers _gates_to_nanocarriers Hydrogels _gates_to_hydrogels _gates_from_hydrogels Delayed-Action Preparations _gates_to_delayed_action_preparations Borneol/GEVs
View Results
Experiment #00000133

ApoE-mediated lipsignaling and EV-delivered bioenergetic substrates both converge on the stabilization of mitochondrial respiratory complexes, which is the requisite physiological precursor for renewed neurogenesis in the hippocampus.

Apolipoprotein E4 _gates_from_apolipoprotein_e4 Mitochondrial Respiration _gates_to_mitochondrial_respiration Extracellular Vesicles _gates_from_extracellular_vesicles Mitochondria _gates_to_mitochondria Energy Metabolism _gates_from_energy_metabolism
View Results
Experiment #00000131

Premise: Environmental metals, though present in many Amyotrophic Lateral Sclerosis anomalous clusters, are debated regarding causality within geographic epistemological data. Hypothesis: If plant derived extracellular vesicles (PDEVs) aerosolized with environmental metals, they could potentially bypass the blood brain barrier via the cribriform plate area. Given this potential method of delivery, environmental metals cannot be ruled out as causal in sporadic ALS until PDEV delivery of the metals is tested in wet lab experiments, but may potentially explain the confounding data.

Environmental Pollutants _gates_from_environmental_pollutants PDEV association _gates_to_pdev_association _gates_from_pdev_association Nose-to-Brain Delivery _gates_to_nose_to_brain_delivery _gates_from_nose_to_brain_delivery Brain Diseases _gates_to_brain_diseases
View Results
Experiment #00000130

Targeted alteration of the oral microbiome via a single polyphenol- and fiber-dense meal plan creates an immediate shift in the microbial composition of involuntary nocturnal microaspiration droplets. Upon entry into the lower respiratory tract, this eubiotic bacterial influx acts as an acute molecular signal that rapidly modulates microglia reactivity and neuroinflammation via the lung-brain axis, bypassing systemic colonic metabolite transport.

Dietary modification _gates_from_dietary_modification Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Respiratory Aspiration _gates_to_respiratory_aspiration _gates_from_respiratory_aspiration Microglia _gates_to_microglia
View Results
Experiment #00000129

COPD Dietary Idea: According to PubMed literature, he following lunchtime meal plan provides nutrients needed for production and regulation of tryptophan and 3-IPA and may help reduce COPD flare-ups, while also providing mucosal support for clearance of debris from the lungs: -2x slices sourdough bread, lightly spread with extra virgin olive oil, garlic, and ginger, with 2x slices of cooked turkey and spinach, with nutritional yeast and hi-maize corn starch mixed into the EVOO (for mucosal system support) -a spinach-based salad with 1 Tbsp EVOO -3 oz pomegranate juice mixed with 3 oz cherry juice

Tryptophan _gates_from_tryptophan Gut Microbiota _gates_to_gut_microbiota _gates_from_gut_microbiota Indolepropionic Acid _gates_to_indolepropionic_acid IPA _gates_from_ipa Lung
View Results
Experiment #00000128

Discovered Hypothesis: Spermidine-mediated autophagic activation may serve as an upstream regulator of lysosomal TMEM175 activity to prevent proteinopathy in C9orf72-ALS/FTD models.

Spermidine _gates_from_spermidine Autophagy _gates_to_autophagy _gates_from_autophagy Lysosomal Integrity _gates_to_lysosomal_integrity _gates_from_lysosomal_integrity TMEM175 _gates_to_tmem175
View Results
Experiment #00000126

Hypothesis: Intranasal delivery of Spermidine-modified Ginseng Extracellular Vesicles (S-GEVs) loaded with multi-targeted mRNA suppresses MARK2-eIF2α-driven RAN translation to prevent dipeptide repeat clogging of FG-nucleoporins, synergizing with progranulin-mediated lysosomal clearance to arrest TMEM106B amyloid accumulation and block the execution of p38-Lamin B1-dependent Karyoptosis in motor neurons.

Spermidine _gates_from_spermidine Lysosomal Degradation _gates_to_lysosomal_degradation _gates_from_lysosomal_degradation Protein Aggregates _gates_to_protein_aggregates _gates_from_protein_aggregates Cell Death _gates_to_cell_death
View Results
Experiment #00000125

Discovery: Considering PubMed #37563705, #42012729, and #42541426, Spermidine is a known inducer of autophagy through EP300 inhibition and TFEB activation. Since TMEM106B amylofilaments induce lysosomal dysfunction, TFEB-driven restoration of lysosomal capacity would logically prevent the accumulation of these filaments.

Spermidine _gates_from_spermidine Transcription Factor EB _gates_to_transcription_factor_eb _gates_from_transcription_factor_eb Lysosomes _gates_to_lysosomes _gates_from_lysosomes TMEM106B protein _gates_to_tmem106b_protein
View Results
Experiment #00000124

Hypothesis: Intranasal delivery of Spermidine-modified Ginseng Extracellular Vesicles (S-GEVs) loaded with GRN mRNA exploits the cribriform plate anatomy to bypass the blood-brain barrier, providing a neuro-targeted delivery system for progranulin gene therapy that acts synergistically with spermidine-induced autophagy to suppress pathological TMEM106B amyloid accumulation and restore endolysosomal homeostasis.

Administration, Intranasal _gates_from_administration__intranasal Olfactory Bulb _gates_to_olfactory_bulb Progranulins _gates_from_progranulins _gates_to_progranulins RNA, Messenger _gates_from_rna__messenger PGRN protein
View Results
Experiment #00000123

Hypothesis: Intranasal delivery of Spermidine-modified Ginseng Extracellular Vesicles (S-GEVs) loaded with GRN mRNA exploits the cribriform plate anatomy to bypass the blood-brain barrier, providing a neuro-targeted delivery system for progranulin gene therapy that acts synergistically with spermidine-induced autophagy to suppress pathological TMEM106B amyloid accumulation and restore endolysosomal homeostasis.

Administration, Intranasal _gates_from_administration__intranasal Olfactory Bulb _gates_to_olfactory_bulb Progranulins _gates_from_progranulins _gates_to_progranulins RNA, Messenger _gates_from_rna__messenger PGRN protein
View Results
Experiment #00000122

Differences and Similarities between Ginger Derived EVs and Ginseng Derived EVs, PubMed Literature, August 2026

Plants, Medicinal _gates_from_plants__medicinal Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles Immunomodulation _gates_to_immunomodulation Plant Extracts _gates_from_plant_extracts Macrophage Polarization
View Results
Experiment #00000119

Hypothesis: Considering PubMed #41177462, Intranasally administered GDEVs, specifically spermidine-modified ginger extracellular vesicles, may offer a multi-target therapeutic strategy for C9orf72-associated ALS by crossing the blood-brain barrier via olfactory routes to potentially deliver gene-editing components, support axonal translation, restore STMN2 expression, and attenuate neuroinflammation.

Spermidine _gates_from_spermidine Olfactory Bulb _gates_to_olfactory_bulb Drug Delivery Systems _gates_from_drug_delivery_systems Stathmin 2 _gates_to_stathmin_2 Eukaryotic Initiation Factor-5A _gates_from_eukaryotic_initiation_factor_5a
View Results
Experiment #00000114

Biohack, Anti-Ebola Hypothesis 1: PDEV-to-macrophage siRNA targeting VP40 Load the plant vesicles with synthetic siRNAs designed to silence VP40 transcription directly inside the macrophage. Exploration of dietary, pharmacological, and repurposed solutions to achieve this.

PDEV isolation _gates_from_pdev_isolation RNA, Small Interfering _gates_to_rna__small_interfering _gates_from_rna__small_interfering Macrophage Activation _gates_to_macrophage_activation _gates_from_macrophage_activation Gene Silencing _gates_to_gene_silencing
View Results
Experiment #00000113

COPD Related Alveoli and Lung Microbiome Axis Restoration Hypothesis: The use of 'pre-digested' (fermented) plant-based nutritional additives as a means to circumvent the bioavailability paradox in patients with gut dysbiosis, effectively using botanical matrices as drug-delivery vehicles. Nucleotide supplementation may enhance the ability of A. muciniphila to modulate gut mucosal barrier integrity in hyperuricemia patients. *Akkermansia* possesses unique enzymes (β-N-acetylhexosaminidases) that allow it to colonize the mucosal layer and participate in mucin degradation.

Fermentation _gates_from_fermentation Bioavailability _gates_to_bioavailability _gates_from_bioavailability Homeostasis _gates_to_homeostasis Plant Preparations _gates_from_plant_preparations Probiotics
View Results
Experiment #00000112

Exploration of fermentation of plant roots used as a gut-brain axis mediator to reduce microglia activation and inflammation.

Plant Roots _gates_from_plant_roots Fermentation _gates_to_fermentation _gates_from_fermentation Gut-Brain Axis _gates_to_gut_brain_axis _gates_from_gut_brain_axis Microglia _gates_to_microglia
View Results
Experiment #00000111

Identify specific patterns of TDP-43 proteinopathy induced cryptic mis-splicing of STMN2 and other "cryptic mis-splicing" patterns found within PubMed Literature, 2026.

DNA-Binding Protein 43 _gates_from_dna_binding_protein_43 Exons _gates_to_exons _gates_from_exons Protein Deficiency _gates_to_protein_deficiency Functional Protein Loss _gates_from_functional_protein_loss Neurodegeneration
View Results
Experiment #00000108

Restoration of efferocytosis is highly dependent on macrophage polarization states; M1 and M2 phenotypes can both contribute to resolution if metabolic cues are corrected.

Metabolic Signaling _gates_from_metabolic_signaling Efferocytic Capacity _gates_to_efferocytic_capacity PIEZO1 Protein _gates_from_piezo1_protein Calcium Influx _gates_to_calcium_influx _gates_from_calcium_influx Metabolic/Efferocytic Pathways
View Results
Experiment #00000107

Restored Clearance of Senescent Neutrophils: Suggested Studies for Limiting Organ Aging

Neutrophils _gates_from_neutrophils Chronic Inflammation (Inflammaging) _gates_to_chronic_inflammation__inflammaging_ Chronic Inflammation _gates_from_chronic_inflammation Efferocytosis _gates_to_efferocytosis Pharmacological Phenomena _gates_from_pharmacological_phenomena
View Results
Experiment #00000105

Gap Analysis: There is no PubMed data showing wet lab data or analysis of TPD-43 proteinopathy found (or not found) in the Cochlear, Spiral, or Scarpa's Ganglion of Amyotrophic Lateral Sclerosis patient data post mortem.

Amyotrophic Lateral Sclerosis _gates_from_amyotrophic_lateral_sclerosis TDP-43 proteinopathy _gates_to_tdp_43_proteinopathy _gates_from_tdp_43_proteinopathy Spiral Ganglion _gates_to_spiral_ganglion Peripheral Nerves _gates_from_peripheral_nerves _gates_to_amyotrophic_lateral_sclerosis
View Results
Experiment #00000104

Candida Auris: Biological and Molecular Pathways, Phenotype Data

Segmental Duplications _gates_from_segmental_duplications Drug Resistance, Fungal _gates_to_drug_resistance__fungal Adaptation, Biological _gates_from_adaptation__biological Immune Evasion _gates_to_immune_evasion _gates_from_immune_evasion Metabolic Networks and Pathways
View Results
Experiment #00000103

Candida Auris: Symptoms, Mechanisms, Transmission, Treatment, Prevention, Wellness Alternatives - PubMed Literature Review August 2026

Biofilms _gates_from_biofilms Biofilm formation _gates_to_biofilm_formation _gates_from_biofilm_formation Refractory transmission _gates_to_refractory_transmission
View Results
Experiment #00000102

Does the combination of anointment and ingestion of millipede secretions by red-fronted lemurs act as a joint action against gastrointestinal parasites?

Known anointing in capuchins _gates_from_known_anointing_in_capuchins Lemuridae _gates_to_lemuridae Observation of Anointment _gates_from_observation_of_anointment Observation _gates_to_observation
View Results
Experiment #00000101

Hypothesis: If Botox were injected into the nerve ending on the third toe on the left foot, the toxin can "climb" retrograde from toe through motor neurons eventually to the brain and temporarily inhibit vesicular docking "from toe to head", potentially allowing a timed pharmacological therapeutic window for toxic EV clearance through the lymph system instead of docking and seeding.

Botulinum Toxins, Type A _gates_from_botulinum_toxins__type_a Axonal Transport _gates_to_axonal_transport _gates_from_axonal_transport SNARE Proteins _gates_to_snare_proteins _gates_from_snare_proteins Lymphatic Vessel Endothelial Hyaluronan Receptor-1 _gates_to_lymphatic_vessel_endothelial_hyaluronan_receptor_1
View Results
Experiment #00000100

Hypothesis: Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging

Aging _gates_from_aging Phagocytosis _gates_to_phagocytosis _gates_from_phagocytosis Neutrophils _gates_to_neutrophils _gates_from_neutrophils _gates_to_aging Indoleacetic Acids
View Results
Experiment #00000098

A 3x3 Evaluation Matrix of Biological Interactions of ARHGAP32, RGNEF (ARHGEF28), and TDP-43 in Neurodegenerative Disease found in PubMed Literature as of August 5, 2026

TDP-43 Proteinopathies _gates_from_tdp_43_proteinopathies RNA Splicing _gates_to_rna_splicing RGNEF (ARHGEF28) _gates_from_rgnef__arhgef28_ TDP-43 _gates_to_tdp_43
View Results
Experiment #00000097

Evaluation of Known Roles of ARHGAP32, RGNEF (ARHGEF28), and TDP-43 in Neurodegenerative Disease found in PubMed Literature as of August 5, 2026

DNA-Binding Proteins _gates_from_dna_binding_proteins RNA Splicing _gates_to_rna_splicing _gates_from_rna_splicing Neuronal Plasticity _gates_to_neuronal_plasticity Synaptic Transmission _gates_to_synaptic_transmission Neuronal Dysfunction
View Results
Experiment #00000096

analysis of the splicing landscape of the frontal cortex in ftld-tdp reveals subtype specific patterns and cryptic splicing

Frontotemporal Lobar Degeneration _gates_from_frontotemporal_lobar_degeneration Alternative Splicing _gates_to_alternative_splicing _gates_from_alternative_splicing RNA Splicing _gates_to_rna_splicing _gates_from_rna_splicing Subtype Specificity _gates_to_subtype_specificity
View Results
Experiment #00000091

Context:A patient is brought into a remote aid station after an explosion inside a covert manufacturing facility. They have a known concussive blast injury, moderate skin irritation, and potential unknown chemical inhalation.Patient Clinical Presentation:Physical Trauma: Grade 2 concussion (confusion, mild disorientation, reactive pupils).Dermatological: Superficial skin burning and blistering across the forearms. The skin smells faintly of burnt almonds or cut grass.Respiratory/Systemic: Shortness of breath, mild tachypnea, and sudden, severe muscle twitching (fasciculations) that began 10 minutes post-exposure.Operational Constraint:Standard advanced diagnostics are unavailable. The primary treatment kit contains standard trauma items, atropine/pralidoxime (2-PAM) autoinjectors, sodium thiosulfate, hydroxycobalamin, and basic field-expedient wellness supplies.Scan Instructions:Run a single scan over the medical and toxicological corpus to map this multi-system presentation. Provide the following outputs using Veridical Enforcement:Differential Toxin Ranking: Based on the combination of blast concussion, skin burning, and the specific onset of muscle twitching vs. scent clues, identify and rank the top two most likely overlapping chemical exposure pathways.The Dynamic Counter-Response (The "If/Then" Fork): Map the exact treatment-response trap. If I suspect Toxin A and administer standard Countermeasure X (e.g., an anticholinergic like atropine), but the patient’s fasciculations instantly stop while their blood pressure dangerously spikes and pupils violently dilate, what secondary hidden pathway does this reaction reveal?Veridical Contraindications: Explicitly cite the exact physiological mechanisms and PubMed-grounded parameters where standard concussion management (e.g., specific fluid resuscitation volumes or sedatives) directly exacerbates the cellular hypoxia or neurotoxicity caused by the suspected chemical inhalants. Do not hallucinate or approximate citations.

Blast Injuries _gates_from_blast_injuries Toxicology _gates_to_toxicology Fasciculations _gates_from_fasciculations Cholinesterase Inhibitors _gates_to_cholinesterase_inhibitors
View Results
Experiment #00000089

Use of MBTPS1 inhibitors is a plausible strategy to prevent the terminal phase of nuclear death in specific cellular contexts.

Membrane-Bound Transcription Factor Peptidase, Site 1 _gates_from_membrane_bound_transcription_factor_peptidase__site_1 SREBP Activation _gates_to_srebp_activation _gates_from_srebp_activation Cellular Lipid Homeostasis _gates_to_cellular_lipid_homeostasis _gates_from_cellular_lipid_homeostasis Terminal Cell Death _gates_to_terminal_cell_death
View Results
Experiment #00000088

Stabilizing the CREB3 tether via S1P/S2P protease inhibition represents a novel mechanism to prevent the terminal phase of neuronal death.

Endoplasmic Reticulum Stress _gates_from_endoplasmic_reticulum_stress Proteolysis _gates_to_proteolysis _gates_from_proteolysis Cyclic AMP-Response Element-Binding Protein _gates_to_cyclic_amp_response_element_binding_protein _gates_from_cyclic_amp_response_element_binding_protein Nuclear Envelope _gates_to_nuclear_envelope
View Results
Experiment #00000087

Karyoptosis, Apoptosis, Ferroptosis: An Amyotrophic Lateral Sclerosis Study of PubMed Literature

Proteotoxic stress _gates_from_proteotoxic_stress Karyoptosis (LaminB1 path) _gates_to_karyoptosis__laminb1_path_ Cell Death _gates_from_cell_death Ferroptosis _gates_to_ferroptosis _gates_from_ferroptosis Lipid Metabolism
View Results
Experiment #00000082

Microbiota-derived acetate can alleviate neurological inflammation and neurodegeneration induced by hypoxia via the upregulation of brain-derived neurotrophic factor (BDNF).

Hypoxia _gates_from_hypoxia Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Acetic Acid _gates_to_acetic_acid _gates_from_acetic_acid Neuroinflammation _gates_to_neuroinflammation
View Results
Experiment #00000080

Prenatal iron deficiency (ID) exacerbates the risk of sudden infant death syndrome (SIDS) by modulating the expression of the hypothalamic orexin system, impairing homeostatic arousal mechanisms during hypoxia.

Anemia, Iron-Deficiency _gates_from_anemia__iron_deficiency Hypothalamic-Hypophyseal System _gates_to_hypothalamic_hypophyseal_system _gates_from_hypothalamic_hypophyseal_system Sudden Infant Death _gates_to_sudden_infant_death _gates_from_sudden_infant_death Orexins _gates_to_orexins
View Results
Experiment #00000077

The use of lysosome-acidifying nanoparticles (AcNPs) could potentially be adapted to treat nanoplastic-induced lysosomal alkalization or membrane rigidification, as these nanoparticles act to restore the degradative capacity lost during environmental contaminant stress.

Nanoplastic exposure _gates_from_nanoplastic_exposure Lysosomes _gates_to_lysosomes _gates_from_lysosomes Autophagy _gates_to_autophagy Nanoparticles _gates_from_nanoparticles Hydrogen-Ion Concentration
View Results
Experiment #00000075

Polystyrene nanoplastics (PS-NPs) may act as a scaffold for the recruitment and accumulation of WDR44 at the lysosomal membrane, thereby accelerating the de novo aggregation of alpha-synuclein in the early stages of PD.

Nanoplastic exposure _gates_from_nanoplastic_exposure Lysosomal Storage Diseases _gates_to_lysosomal_storage_diseases _gates_from_lysosomal_storage_diseases alpha-Synuclein _gates_to_alpha_synuclein WDR44 _gates_from_wdr44 Protein Aggregates
View Results
Experiment #00000074

OGT (O-GlcNAc transferase) modulation via pharmacological agonists can prevent degeneration of cranial nerves following traumatic or surgical stress.

Trauma/Stress _gates_from_trauma_stress Ferritinophagy/Oxidative Stress _gates_to_ferritinophagy_oxidative_stress Autophagy _gates_from_autophagy N-Acetylglucosaminyltransferases _gates_to_n_acetylglucosaminyltransferases _gates_from_n_acetylglucosaminyltransferases Neuronal Survival
View Results
Experiment #00000070

What types of infections might cause a high C-Reactive Protein result?

Pathogen presence _gates_from_pathogen_presence Immunity, Innate _gates_to_immunity__innate _gates_from_immunity__innate C-Reactive Protein _gates_to_c_reactive_protein _gates_from_c_reactive_protein Biomarkers _gates_to_biomarkers
View Results
Experiment #00000067

Frontotemporal dementia; Splicing; TDP-43; Transcriptomics.

DNA-Binding Protein-43 _gates_from_dna_binding_protein_43 RNA Splicing _gates_to_rna_splicing _gates_from_rna_splicing Neuronal dysfunction _gates_to_neuronal_dysfunction Exons _gates_to_exons Splicing defects
View Results
Experiment #00000062

NESCO-induced pyroptosis in the peritoneal microenvironment might be attenuated by the upregulation of 11-oxygenated androgens in the systemic circulation.

Endometriosis _gates_from_endometriosis Tumor Microenvironment _gates_to_tumor_microenvironment Androgens _gates_from_androgens _gates_to_endometriosis Disease Models, Animal _gates_from_disease_models__animal NESCO and Androgens
View Results
Experiment #00000057

Amyotrophic Lateral Sclerosis breakthrough updates as of July 2026

Systemic Disease _gates_from_systemic_disease Gene Expression Regulation _gates_to_gene_expression_regulation
View Results
Experiment #00000053

How do specific microbial-derived metabolites, beyond short-chain fatty acids and bile acids, function as 'molecular switches' to program hepatic lipid metabolism during the earliest stages of steatotic liver disease?

Microbial composition _gates_from_microbial_composition Metabolomics _gates_to_metabolomics _gates_from_metabolomics Signal Transduction _gates_to_signal_transduction Host signaling _gates_from_host_signaling Lipid Metabolism
View Results
Experiment #00000050

What are the symptoms of toxoplasmosis and how is it transmitted?

Host _gates_from_host Infection _gates_to_infection _gates_from_infection Clinical Symptoms _gates_to_clinical_symptoms Animals, Domestic _gates_from_animals__domestic Environment
View Results
Experiment #00000049

Explain the risks of veridical AI and human job displacement.

Artificial Intelligence _gates_from_artificial_intelligence Efficiency, Organizational _gates_to_efficiency__organizational _gates_from_efficiency__organizational Employment _gates_to_employment _gates_from_employment Patient-Centered Care _gates_to_patient_centered_care
View Results
Experiment #00000048

The ALS-T2D comorbidity is driven by a bidirectional, exosome-mediated proteostatic collapse. Peripheral tissues (muscle, pancreas) dictate CNS TDP-43 stability via exosomal miRNAs (miR-126a-5p) and glucose-dependent modifications (O-GlcNAcylation). Conversely, pharmacological activation of ubiquitin-peptidases (e.g., Acarbose targeting USP46) or restitution of glycolytic cofactors (F2,6BP) represent novel, cross-disciplinary therapeutic targets capable of halting systemic proteinopathy.

Diabetes Mellitus, Type 2 _gates_from_diabetes_mellitus__type_2 Extracellular Vesicles _gates_to_extracellular_vesicles _gates_from_extracellular_vesicles DNA-Binding Proteins _gates_to_dna_binding_proteins _gates_from_dna_binding_proteins Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis
View Results
Experiment #00000045

Sporadic ALS and C9orf72 affected ALS are two different pathologies and the mixing of test groups and datasets has produced confounding results.

Molecular Heterogeneity _gates_from_molecular_heterogeneity Diagnostic Errors _gates_to_diagnostic_errors Biomarkers _gates_to_biomarkers Genetic Heterogeneity _gates_from_genetic_heterogeneity Molecular Typing _gates_to_molecular_typing
View Results
Experiment #00000044

What kinds of changes in voice occur prior to Amyotrophic Lateral Sclerosis onset?

Amyotrophic Lateral Sclerosis _gates_from_amyotrophic_lateral_sclerosis Bulbar Palsy _gates_to_bulbar_palsy _gates_from_bulbar_palsy Speech _gates_to_speech _gates_from_speech Missing _gates_to_missing
View Results
Experiment #00000043

Subject-specific prognostic models can now predict articulatory precision and ALSFRS-R speech subscores 30–90 days in advance.

Speech-Language Pathology _gates_from_speech_language_pathology Algorithms _gates_to_algorithms _gates_from_algorithms Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis Speech _gates_from_speech Bulbar Palsy
View Results
Experiment #00000041

What is the biological/molecular pathway that causes sarcopenia with the scope of COPD? Do the quads serve as a pathological progression indicator?

Pulmonary Disease, Chronic Obstructive _gates_from_pulmonary_disease__chronic_obstructive Systemic Inflammatory Response Syndrome _gates_to_systemic_inflammatory_response_syndrome _gates_from_systemic_inflammatory_response_syndrome Signal Transduction _gates_to_signal_transduction _gates_from_signal_transduction Muscular Atrophy _gates_to_muscular_atrophy
View Results
Experiment #00000039

What is the current evidence for RGNEF (ARHGEF28) functioning as a primary upstream regulator of axonal transport and TDP-43 homeostasis in ALS, and how does the failure of this 'terminal tether' initiate the pathological continuum compared to downstream protein aggregation?

Metabolic Stress _gates_from_metabolic_stress Protein Aggregation _gates_to_protein_aggregation _gates_from_protein_aggregation RNA Metabolism _gates_to_rna_metabolism _gates_from_rna_metabolism Axonal Transport _gates_to_axonal_transport
View Results
Experiment #00000038

Map the direct mechanical and axonal transport pathways connecting intranasal administration or trigeminal nerve delivery to the clearance of TDP-43 aggregates in sporadic ALS, and the delivery of CRISPR-Cas/ASO gene therapies targeting C9orf72 hexanucleotide repeat expansions in the cerebellum and brainstem.

Intranasal Route _gates_from_intranasal_route Blood-Brain Barrier _gates_to_blood_brain_barrier C9orf72 Protein _gates_to_c9orf72_protein _gates_from_c9orf72_protein Brain _gates_to_brain Intranasal Administration
View Results
Experiment #00000036

What is Karyoptosis and how does it align with past and present neurodegenerative disease research? Does Karyoptosis provide a new context in which a new class of repurposed therapeutics is formed?

Proteotoxic Stress _gates_from_proteotoxic_stress Cyclic AMP-Response Element Binding Protein _gates_to_cyclic_amp_response_element_binding_protein _gates_from_cyclic_amp_response_element_binding_protein Nuclear Envelope _gates_to_nuclear_envelope _gates_from_nuclear_envelope Apoptosis _gates_to_apoptosis
View Results
Experiment #00000035

What changes in a person's voice occur prior to Amyotrophic Lateral Sclerosis onset that may be useful as a non-clinical (or clinical if possible) early detection of the disease?

Motor Neuron Disease _gates_from_motor_neuron_disease Muscle Weakness _gates_to_muscle_weakness _gates_from_muscle_weakness Vocal Cord Dysfunction _gates_to_vocal_cord_dysfunction Quantitative Analysis _gates_from_quantitative_analysis Biomarkers
View Results
Experiment #00000034

Is cannabis a hyperaccumulator of metals such as Cadmium?

Cannabis sativa _gates_from_cannabis_sativa Biodegradation _gates_to_biodegradation _gates_from_biodegradation Hyperaccumulation status _gates_to_hyperaccumulation_status Metals, Heavy _gates_to_metals__heavy _gates_from_metals__heavy
View Results
Experiment #00000033

Acinetobacter baumannii and Pseudomonas may share pathways with other pathologies and there may be therapeutic bacteriophages or other non-antibiotic solutions hidden with in PubMed literature.

Drug Resistance, Multiple, Bacterial _gates_from_drug_resistance__multiple__bacterial Anti-Bacterial Agents _gates_to_anti_bacterial_agents Multidrug resistance _gates_from_multidrug_resistance Therapeutics _gates_to_therapeutics Biofilms _gates_from_biofilms
View Results
Experiment #00000031

Why are frontotemporal dementia and c9orf72 ALS considered different diseases if they are both driven by the same abnormal expansion of a GGGGCC (G₄C₂) sequence in the first intron of the C9orf72 gene? Is it logical to think that CRISPR therapeutics for FTD potentially be used for ALS as well?

C9orf72 expansion _gates_from_c9orf72_expansion Gene Expression Regulation _gates_to_gene_expression_regulation _gates_from_gene_expression_regulation Protein Aggregation, Pathological _gates_to_protein_aggregation__pathological _gates_from_protein_aggregation__pathological CRISPR-Cas Systems _gates_to_crispr_cas_systems
View Results
Experiment #00000028

Are there any vitamins or supplements that have either old or recent clinical trial evidence of being beneficial for preventing or reducing migraines that may have been overlooked? I cannot afford the current migraine medications.

Dietary Factors _gates_from_dietary_factors Mitochondrial Dysfunction _gates_to_mitochondrial_dysfunction _gates_from_mitochondrial_dysfunction Hyperacusis _gates_to_hyperacusis Neurogenic Inflammation _gates_from_neurogenic_inflammation Dietary Supplements
View Results
Experiment #00000026

Can post-lyme disease syndrome be cured?

Lyme Disease _gates_from_lyme_disease Anti-Bacterial Agents _gates_to_anti_bacterial_agents _gates_from_anti_bacterial_agents Post-Treatment Lyme Disease Syndrome _gates_to_post_treatment_lyme_disease_syndrome _gates_from_post_treatment_lyme_disease_syndrome 10-20% of cases _gates_to_10_20__of_cases
View Results
Experiment #00000024

If RGNEF fails agitate and regulate TDP-43 at the RGNEF NF242 Terminal, does this cause TDP-43 propteinopathy?

Protein Interaction Mapping _gates_from_protein_interaction_mapping RNA Stability _gates_to_rna_stability Peptide Fragments _gates_from_peptide_fragments RNA Recognition Motif _gates_to_rna_recognition_motif Metabolic stress _gates_from_metabolic_stress
View Results
Experiment #00000021

How long until I can sleep on my side after knee replacement surgery?

Arthroplasty, Replacement, Knee _gates_from_arthroplasty__replacement__knee Postural Balance _gates_to_postural_balance _gates_from_postural_balance Range of Motion, Articular _gates_to_range_of_motion__articular
View Results
Experiment #00000019

What is the role of 3-indolepropionic acid within the body, and what foods or nutrients may help replenish it if deficient?

Edible Grain _gates_from_edible_grain Clostridium sporogenes _gates_to_clostridium_sporogenes Gastrointestinal Microbiome _gates_from_gastrointestinal_microbiome 3-indolepropionic acid _gates_to_3_indolepropionic_acid _gates_from_3_indolepropionic_acid Signal Transduction
View Results
Experiment #00000016

Analyze the potential for zinc-binding competition between synaptic transporters (e.g., SLC39A8, ZnT3) and ALS-associated proteins (RGNEF, TDP-43) in the RGC-thalamic axis. Can this competition explain the coexistence of RGC excitotoxicity and STMN2 depletion in clinical samples?

TAR DNA-Binding Protein 43 _gates_from_tar_dna_binding_protein_43 Stathmin 2 _gates_to_stathmin_2 SLC39A8 protein, human _gates_from_slc39a8_protein__human Zinc _gates_to_zinc Excitotoxicity _gates_from_excitotoxicity
View Results
Experiment #00000015

Given that schizophrenia is characterized by a deficit in the attenuation of sensory input via corollary discharge, how might pathologically elevated RGC signaling—potentially caused by synaptic glutamate overflow without zinc modulation—interfere with the thalamic integration of extra-retinal CD signals to effectively reverse the predictive timing of visual stability?

SLC39A8 Protein _gates_from_slc39a8_protein Zinc Deficiency _gates_to_zinc_deficiency _gates_from_zinc_deficiency Glutamic Acid _gates_to_glutamic_acid _gates_from_glutamic_acid Thalamus _gates_to_thalamus
View Results
Experiment #00000012

If a toxin with a thermodynamic affinity for Zinc GREATER THAN that of Glutamate AND LESS THAN that of RGNEF, under certain conditions a pathway exists wherein the toxin could shuttle synaptic retinal zinc to RGNEF, thus potentially ultimately resulting in the retinal TDP-43 proteinopathy seen in the retina post mortem in Sporadic Amyotrophic Lateral Sclerosis

Synaptic Zinc _gates_from_synaptic_zinc Receptors, Glutamate _gates_to_receptors__glutamate _gates_from_receptors__glutamate Zinc Dyshomeostasis in RGCs _gates_to_zinc_dyshomeostasis_in_rgcs _gates_from_zinc_dyshomeostasis_in_rgcs TDP-43 Proteinopathy _gates_to_tdp_43_proteinopathy
View Results
Experiment #00000007

Simply put, we still don’t know why neurons are dying in ALS, and why motor neurons die while other types of neurons don’t. Even for genetic forms c9orf72 familial ALS, why is it that the mutation is in every cell but the motor neurons are dying ie have increased susceptibility?

Axonal Transport _gates_from_axonal_transport Motor Neuron Disease _gates_to_motor_neuron_disease C9orf72 Repeat Expansion _gates_from_c9orf72_repeat_expansion Dipeptide Repeats _gates_to_dipeptide_repeats _gates_from_dipeptide_repeats VAPB protein, human
View Results
Experiment #00000002

Does chronic latent Epstein-Barr Virus (EBV) reactivation drive microglial activation and subsequent myelin destruction in Multiple Sclerosis via the activation of the cGAS-STING innate immune pathway?

Epstein-Barr Virus Infections _gates_from_epstein_barr_virus_infections Microglial Activation _gates_to_microglial_activation _gates_from_microglial_activation cGAS-STING Signaling _gates_to_cgas_sting_signaling _gates_from_cgas_sting_signaling Demyelinating Diseases _gates_to_demyelinating_diseases
View Results
Experiment #00000001

Why does Amyotrophic Lateral Sclerosis seem to be on the rise?

Demographic Aging _gates_from_demographic_aging Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis At-Risk Populations _gates_to_at_risk_populations Palliative Care _gates_from_palliative_care Survival Rate _gates_to_survival_rate
View Results