PathMap Literature Based Discovery Engine

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Experiment #00000141

Hypothesis: Repurposing IVF screening tools to verify CRISPR-corrected induced pluripotent stem cells (iPSCs), combined with in vitro gametogenesis, may potentially create disease-free germlines that could eradicate heritable hematological mutations in future generations, such as sickle cell disease.

CRISPR-Cas Systems _gates_from_crispr_cas_systems Induced Pluripotent Stem Cells _gates_to_induced_pluripotent_stem_cells _gates_from_induced_pluripotent_stem_cells Anemia, Sickle Cell _gates_to_anemia__sickle_cell
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Experiment #00000128

Discovered Hypothesis: Spermidine-mediated autophagic activation may serve as an upstream regulator of lysosomal TMEM175 activity to prevent proteinopathy in C9orf72-ALS/FTD models.

Spermidine _gates_from_spermidine Autophagy _gates_to_autophagy _gates_from_autophagy Lysosomal Integrity _gates_to_lysosomal_integrity _gates_from_lysosomal_integrity TMEM175 _gates_to_tmem175
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Experiment #00000076

Nanoplastic-induced lysosomal membrane remodeling may sequester WDR44, creating a 'hotspot' for α-synuclein aggregation initiation.

Nanoplastics internalization _gates_from_nanoplastics_internalization Lysosomal accumulation _gates_to_lysosomal_accumulation _gates_from_lysosomal_accumulation Lysosomal Membranes _gates_to_lysosomal_membranes WDR44 _gates_from_wdr44 WDR44 protein
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Experiment #00000062

NESCO-induced pyroptosis in the peritoneal microenvironment might be attenuated by the upregulation of 11-oxygenated androgens in the systemic circulation.

Endometriosis _gates_from_endometriosis Tumor Microenvironment _gates_to_tumor_microenvironment Androgens _gates_from_androgens _gates_to_endometriosis Disease Models, Animal _gates_from_disease_models__animal NESCO and Androgens
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Experiment #00000043

Subject-specific prognostic models can now predict articulatory precision and ALSFRS-R speech subscores 30–90 days in advance.

Speech-Language Pathology _gates_from_speech_language_pathology Algorithms _gates_to_algorithms _gates_from_algorithms Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis Speech _gates_from_speech Bulbar Palsy
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Experiment #00000022

Do Bulbar Amyotrophic Lateral Sclerosis patients have TDP43 proteinopathy in cochlear/spiral ganglion post mortem?

Ubiquilin-1 _gates_from_ubiquilin_1 TDP-43 Proteinopathies _gates_to_tdp_43_proteinopathies _gates_from_tdp_43_proteinopathies Amyotrophic Lateral Sclerosis _gates_to_amyotrophic_lateral_sclerosis Disease Models, Animal _gates_from_disease_models__animal Cochlear Nucleus
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Experiment #00000015

Given that schizophrenia is characterized by a deficit in the attenuation of sensory input via corollary discharge, how might pathologically elevated RGC signaling—potentially caused by synaptic glutamate overflow without zinc modulation—interfere with the thalamic integration of extra-retinal CD signals to effectively reverse the predictive timing of visual stability?

SLC39A8 Protein _gates_from_slc39a8_protein Zinc Deficiency _gates_to_zinc_deficiency _gates_from_zinc_deficiency Glutamic Acid _gates_to_glutamic_acid _gates_from_glutamic_acid Thalamus _gates_to_thalamus
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Experiment #00000004

Can the identified lysosomal-targeted acidic nanoparticles (AcNPs) or specific small-molecule chaperones effectively reverse established alpha-synuclein aggregation in chronic exposure models, and do they provide neuroprotection against subsequent environmental pollutant insults?

Lysosomal Storage Diseases _gates_from_lysosomal_storage_diseases alpha-Synuclein _gates_to_alpha_synuclein Alpha-synuclein aggregation _gates_from_alpha_synuclein_aggregation Molecular Chaperones _gates_to_molecular_chaperones Lysosomes _gates_from_lysosomes
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