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Experiment #00000141
Hypothesis: Repurposing IVF screening tools to verify CRISPR-corrected induced pluripotent stem cells (iPSCs), combined with in vitro gametogenesis, may potentially create disease-free germlines that could eradicate heritable hematological mutations in future generations, such as sickle cell disease.
CRISPR-Cas Systems
_gates_from_crispr_cas_systems
Induced Pluripotent Stem Cells
_gates_to_induced_pluripotent_stem_cells
_gates_from_induced_pluripotent_stem_cells
Anemia, Sickle Cell
_gates_to_anemia__sickle_cell
View Results
Experiment #00000105
Gap Analysis: There is no PubMed data showing wet lab data or analysis of TPD-43 proteinopathy found (or not found) in the Cochlear, Spiral, or Scarpa's Ganglion of Amyotrophic Lateral Sclerosis patient data post mortem.
Amyotrophic Lateral Sclerosis
_gates_from_amyotrophic_lateral_sclerosis
TDP-43 proteinopathy
_gates_to_tdp_43_proteinopathy
_gates_from_tdp_43_proteinopathy
Spiral Ganglion
_gates_to_spiral_ganglion
Peripheral Nerves
_gates_from_peripheral_nerves
_gates_to_amyotrophic_lateral_sclerosis
Noise-Induced Hearing Loss
_gates_from_noise_induced_hearing_loss
DNA-Binding Proteins
_gates_to_dna_binding_proteins
_gates_from_dna_binding_proteins
Autophagy
_gates_to_autophagy
_gates_from_autophagy
Hearing Disorders
_gates_to_hearing_disorders
+10 more
View Results
Experiment #00000092
A Top-Down Mechanism for Sporadic ALS Initiated by Ocular Metal Dyshomeostasis and Retrograde Exosomal Transport along the Subcortical Visual Axis
Eye Diseases
_gates_from_eye_diseases
Retinal Diseases
_gates_to_retinal_diseases
_gates_from_retinal_diseases
Extracellular Vesicles
_gates_to_extracellular_vesicles
_gates_from_extracellular_vesicles
Motor Neurons
_gates_to_motor_neurons
View Results
Experiment #00000071
Do any recent non-proliferative diabetic retinopathy clinical trials reveal anything about Amyotrophic Lateral Sclerosis?
Diabetic Retinopathy
_gates_from_diabetic_retinopathy
ALS
_gates_to_als
Retinal Diseases
_gates_to_retinal_diseases
_gates_from_retinal_diseases
Neurodegenerative Diseases
_gates_to_neurodegenerative_diseases
_gates_from_neurodegenerative_diseases
Riluzole
_gates_to_riluzole
+2 more
View Results
Experiment #00000069
Keyword Analysis: diabetes; retinal diabetic neuropathy; ganglion cells; synapses; SPG302; tazbentetol; visual function; synaptic regeneration; neuroprotection; blindness; glaucoma
Glucose
_gates_from_glucose
Mitochondria
_gates_to_mitochondria
Mitochondrial Dysfunction
_gates_from_mitochondrial_dysfunction
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
SPG302 Treatment
_gates_from_spg302_treatment
Synapses
_gates_to_synapses
Hyperglycemia
_gates_from_hyperglycemia
Retinal Degeneration
_gates_to_retinal_degeneration
_gates_from_retinal_degeneration
_gates_from_synapses
Spastic Paraplegia, Hereditary
_gates_to_spastic_paraplegia__hereditary
Diabetes
_gates_from_diabetes
_gates_from_retinal_ganglion_cells
+13 more
View Results
Experiment #00000065
Does pathologically seeded TDP-43 exit the retina via anterograde axonal transport along the optic tract to midbrain hubs, enter the systemic circulation inside extracellular vesicles, and subsequently traffic into pancreatic beta-cells to accelerate type 2 diabetes phenotypes?
TAR DNA-Binding Protein 43
_gates_from_tar_dna_binding_protein_43
Extracellular Vesicles
_gates_to_extracellular_vesicles
Systemic circulating EVs
_gates_from_systemic_circulating_evs
Insulin-Secreting Cells
_gates_to_insulin_secreting_cells
Axonal Transport
_gates_to_axonal_transport
_gates_from_extracellular_vesicles
Diabetes Mellitus, Type 2
_gates_to_diabetes_mellitus__type_2
Pancreatic Beta-cells
_gates_to_pancreatic_beta_cells
Calcium Channels, L-Type
_gates_to_calcium_channels__l_type
+7 more
View Results
Experiment #00000064
Lon Protease, Alternaria; IL-33; TSLP; alarmins; asthma; chronic rhinosinusitis; fungal allergen; innate lymphoid cells
Alternaria
_gates_from_alternaria
Alarmins
_gates_to_alarmins
_gates_from_alarmins
Immunity, Innate
_gates_to_immunity__innate
_gates_from_immunity__innate
Lon-Peptidase
_gates_to_lon_peptidase
Fungal Proteins
_gates_from_fungal_proteins
Signal Transduction
_gates_from_signal_transduction
Cytokines
_gates_to_cytokines
Mitochondrial Diseases
_gates_from_mitochondrial_diseases
+8 more
View Results
Experiment #00000023
Does misfolded TDP43 affect Retinal Ganglion Cell STMN2 ability to repair in a similar way as what how it was shown to affect motor neurons with cryptic mis-splicing?
TDP-43 pathology
_gates_from_tdp_43_pathology
RNA Splicing
_gates_to_rna_splicing
_gates_from_rna_splicing
Stathmin 2
_gates_to_stathmin_2
Vitreous Body
_gates_to_vitreous_body
DNA-Binding Protein-43
_gates_from_dna_binding_protein_43
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
Cell Nucleus
_gates_from_cell_nucleus
_gates_from_stathmin_2
Axonal Degeneration
_gates_to_axonal_degeneration
Axons
_gates_to_axons
_gates_from_axons
+11 more
View Results
Experiment #00000022
Do Bulbar Amyotrophic Lateral Sclerosis patients have TDP43 proteinopathy in cochlear/spiral ganglion post mortem?
Ubiquilin-1
_gates_from_ubiquilin_1
TDP-43 Proteinopathies
_gates_to_tdp_43_proteinopathies
_gates_from_tdp_43_proteinopathies
Amyotrophic Lateral Sclerosis
_gates_to_amyotrophic_lateral_sclerosis
Disease Models, Animal
_gates_from_disease_models__animal
Cochlear Nucleus
_gates_to_cochlear_nucleus
_gates_from_cochlear_nucleus
TDP-43 proteinopathy
_gates_to_tdp_43_proteinopathy
_gates_from_amyotrophic_lateral_sclerosis
_gates_from_tdp_43_proteinopathy
Spiral Ganglion Neurons
_gates_to_spiral_ganglion_neurons
+8 more
View Results
Experiment #00000020
Does age-related gut dysbiosis drive sarcopenia by activating the cGAS-STING inflammatory pathway to suppress satellite cell renewal?
Gastrointestinal Microbiome
_gates_from_gastrointestinal_microbiome
Inflammation
_gates_to_inflammation
_gates_from_inflammation
cGAS-STING Pathway Activation
_gates_to_cgas_sting_pathway_activation
_gates_from_cgas_sting_pathway_activation
Satellite Cells
_gates_to_satellite_cells
Mitochondrial dysfunction
_gates_to_mitochondrial_dysfunction
_gates_from_mitochondrial_dysfunction
DNA, Mitochondrial
_gates_to_dna__mitochondrial
_gates_from_dna__mitochondrial
cGAS-STING Pathway
_gates_to_cgas_sting_pathway
_gates_from_cgas_sting_pathway
Inflammaging/Senescence
_gates_to_inflammaging_senescence
_gates_from_inflammaging_senescence
Muscular Atrophy
_gates_to_muscular_atrophy
+14 more
View Results
Experiment #00000016
Analyze the potential for zinc-binding competition between synaptic transporters (e.g., SLC39A8, ZnT3) and ALS-associated proteins (RGNEF, TDP-43) in the RGC-thalamic axis. Can this competition explain the coexistence of RGC excitotoxicity and STMN2 depletion in clinical samples?
TAR DNA-Binding Protein 43
_gates_from_tar_dna_binding_protein_43
Stathmin 2
_gates_to_stathmin_2
SLC39A8 protein, human
_gates_from_slc39a8_protein__human
Zinc
_gates_to_zinc
Excitotoxicity
_gates_from_excitotoxicity
Retinal Ganglion Cells
_gates_to_retinal_ganglion_cells
Cation Transport Proteins
_gates_from_cation_transport_proteins
Transcription, Genetic
_gates_to_transcription__genetic
_gates_from_zinc
Binding Sites
_gates_to_binding_sites
_gates_to_tar_dna_binding_protein_43
+10 more
View Results
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Reference Abstract
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Source: PubMed
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