PathMap Literature Based Discovery Engine
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Breakthroughs is bulbar palsy found in PubMed Literature, July 2026.


What types of infections might cause a high C-Reactive Protein result?


ALS; FUS; STMN2; TDP-43; protein translation; stress granule


Breakthroughs in Alzheimer's Research Discovered in PubMed Literature, July 2026


Amyotrophic Lateral Sclerosis breakthrough updates as of July 2026


The ALS-T2D comorbidity is driven by a bidirectional, exosome-mediated proteostatic collapse. Peripheral tissues (muscle, pancreas) dictate CNS TDP-43 stability via exosomal miRNAs (miR-126a-5p) and glucose-dependent modifications (O-GlcNAcylation). Conversely, pharmacological activation of ubiquitin-peptidases (e.g., Acarbose targeting USP46) or restitution of glycolytic cofactors (F2,6BP) represent novel, cross-disciplinary therapeutic targets capable of halting systemic proteinopathy.


Diabetes Mellitus, Type 2
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Extracellular Vesicles
_gates_to_extracellular_vesicles
_gates_from_extracellular_vesicles
DNA-Binding Proteins
_gates_to_dna_binding_proteins
_gates_from_dna_binding_proteins
Amyotrophic Lateral Sclerosis
_gates_to_amyotrophic_lateral_sclerosis
Can inhaled COVID-19 vaccinations be used to help treat COPD?


Pulmonary Disease, Chronic Obstructive
_gates_from_pulmonary_disease__chronic_obstructive
Administration, Inhalation
_gates_to_administration__inhalation
_gates_from_administration__inhalation
Immunity, Mucosal
_gates_to_immunity__mucosal
Mucous Membrane
_gates_to_mucous_membrane
_gates_from_mucous_membrane
Why are frontotemporal dementia and c9orf72 ALS considered different diseases if they are both driven by the same abnormal expansion of a GGGGCC (G₄C₂) sequence in the first intron of the C9orf72 gene? Is it logical to think that CRISPR therapeutics for FTD potentially be used for ALS as well?


C9orf72 expansion
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Gene Expression Regulation
_gates_to_gene_expression_regulation
_gates_from_gene_expression_regulation
Protein Aggregation, Pathological
_gates_to_protein_aggregation__pathological
_gates_from_protein_aggregation__pathological
CRISPR-Cas Systems
_gates_to_crispr_cas_systems
Can post-lyme disease syndrome be cured?


Lyme Disease
_gates_from_lyme_disease
Anti-Bacterial Agents
_gates_to_anti_bacterial_agents
_gates_from_anti_bacterial_agents
Post-Treatment Lyme Disease Syndrome
_gates_to_post_treatment_lyme_disease_syndrome
_gates_from_post_treatment_lyme_disease_syndrome
10-20% of cases
_gates_to_10_20__of_cases
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