PathMap Literature Based Discovery Engine

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Experiment #00000139

Foundational Dietary Theory: The dietary synergy between Hi-Maize and 6x Spermidine Yeast creates a potential cellular supply-and-clearance loop within the brain's astrocytes. Circulating spermidine metabolites utilize documented astrocytic polyamine uptake systems to access the central nervous system. Once inside, this exogenous spermidine drives FAM134B-mediated ER-phagy, clearing the endoplasmic reticulum matrix. This clearance removes the ER-stress bottleneck, allowing newly transcribed astrocytic EAAT2—upregulated by gut-derived butyrate from Hi-Maize fermentation—to successfully traffic to the plasma membrane and mitigate synaptic glutamate excitotoxicity.

Starch, Resistant _gates_from_starch__resistant Butyric Acid _gates_to_butyric_acid _gates_from_butyric_acid Glutamate Plasma Membrane Transport Proteins _gates_to_glutamate_plasma_membrane_transport_proteins Spermidine _gates_from_spermidine Autophagy
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Experiment #00000138

Dietary butyrate from resistant starch may synergize with sulforaphane-driven Nrf2 activation and spermidine-mediated FAM134B ER-phagy in order to restore astrocytic EAAT2 membrane trafficking and potentially clear synaptic glutamate excitotoxicity in neurodegeneration. (Literature Based Discovery)

Starch, Resistant _gates_from_starch__resistant Butyrate _gates_to_butyrate _gates_from_butyrate NF-E2-Related Factor 2 _gates_to_nf_e2_related_factor_2 Sulforaphane _gates_from_sulforaphane Spermidine
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Experiment #00000130

Targeted alteration of the oral microbiome via a single polyphenol- and fiber-dense meal plan creates an immediate shift in the microbial composition of involuntary nocturnal microaspiration droplets. Upon entry into the lower respiratory tract, this eubiotic bacterial influx acts as an acute molecular signal that rapidly modulates microglia reactivity and neuroinflammation via the lung-brain axis, bypassing systemic colonic metabolite transport.

Dietary modification _gates_from_dietary_modification Dysbiosis _gates_to_dysbiosis _gates_from_dysbiosis Respiratory Aspiration _gates_to_respiratory_aspiration _gates_from_respiratory_aspiration Microglia _gates_to_microglia
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Experiment #00000129

COPD Dietary Idea: According to PubMed literature, he following lunchtime meal plan provides nutrients needed for production and regulation of tryptophan and 3-IPA and may help reduce COPD flare-ups, while also providing mucosal support for clearance of debris from the lungs: -2x slices sourdough bread, lightly spread with extra virgin olive oil, garlic, and ginger, with 2x slices of cooked turkey and spinach, with nutritional yeast and hi-maize corn starch mixed into the EVOO (for mucosal system support) -a spinach-based salad with 1 Tbsp EVOO -3 oz pomegranate juice mixed with 3 oz cherry juice

Tryptophan _gates_from_tryptophan Gut Microbiota _gates_to_gut_microbiota _gates_from_gut_microbiota Indolepropionic Acid _gates_to_indolepropionic_acid IPA _gates_from_ipa Lung
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Experiment #00000124

Hypothesis: Intranasal delivery of Spermidine-modified Ginseng Extracellular Vesicles (S-GEVs) loaded with GRN mRNA exploits the cribriform plate anatomy to bypass the blood-brain barrier, providing a neuro-targeted delivery system for progranulin gene therapy that acts synergistically with spermidine-induced autophagy to suppress pathological TMEM106B amyloid accumulation and restore endolysosomal homeostasis.

Administration, Intranasal _gates_from_administration__intranasal Olfactory Bulb _gates_to_olfactory_bulb Progranulins _gates_from_progranulins _gates_to_progranulins RNA, Messenger _gates_from_rna__messenger PGRN protein
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Experiment #00000123

Hypothesis: Intranasal delivery of Spermidine-modified Ginseng Extracellular Vesicles (S-GEVs) loaded with GRN mRNA exploits the cribriform plate anatomy to bypass the blood-brain barrier, providing a neuro-targeted delivery system for progranulin gene therapy that acts synergistically with spermidine-induced autophagy to suppress pathological TMEM106B amyloid accumulation and restore endolysosomal homeostasis.

Administration, Intranasal _gates_from_administration__intranasal Olfactory Bulb _gates_to_olfactory_bulb Progranulins _gates_from_progranulins _gates_to_progranulins RNA, Messenger _gates_from_rna__messenger PGRN protein
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Experiment #00000121

Exploration: The gut microbial metabolite 3-indolepropionic acid as a functional neuroprotective agent against intracerebral hemorrhage: integrating epidemiological screening with in vivo validation.

Dietary Tryptophan _gates_from_dietary_tryptophan Gut Microbiota _gates_to_gut_microbiota _gates_from_gut_microbiota 3-indolepropionic acid (3-IPA) _gates_to_3_indolepropionic_acid__3_ipa_ _gates_from_3_indolepropionic_acid__3_ipa_ Neuroprotection in ICH _gates_to_neuroprotection_in_ich
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Experiment #00000114

Biohack, Anti-Ebola Hypothesis 1: PDEV-to-macrophage siRNA targeting VP40 Load the plant vesicles with synthetic siRNAs designed to silence VP40 transcription directly inside the macrophage. Exploration of dietary, pharmacological, and repurposed solutions to achieve this.

PDEV isolation _gates_from_pdev_isolation RNA, Small Interfering _gates_to_rna__small_interfering _gates_from_rna__small_interfering Macrophage Activation _gates_to_macrophage_activation _gates_from_macrophage_activation Gene Silencing _gates_to_gene_silencing
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Experiment #00000109

Clinically prescribed periodic "fasting" (caloric restriction), combined with dietary modification to include Omega-3 polyunsaturated fatty acids from fish and monounsaturated fats from olive oil, dietary fibers, and polyphenols from rich plant compounds may lower or balance toxic accumulated ceramides (like C16:0) via inhibition and metabolic processing in order to reduce organ aging and improve Circadian Efferocytosis Oscillation.

Caloric Restriction _gates_from_caloric_restriction Ceramides _gates_to_ceramides _gates_from_ceramides Insulin Resistance _gates_to_insulin_resistance Efferocytosis _gates_from_efferocytosis Inflammation
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Experiment #00000107

Restored Clearance of Senescent Neutrophils: Suggested Studies for Limiting Organ Aging

Neutrophils _gates_from_neutrophils Chronic Inflammation (Inflammaging) _gates_to_chronic_inflammation__inflammaging_ Chronic Inflammation _gates_from_chronic_inflammation Efferocytosis _gates_to_efferocytosis Pharmacological Phenomena _gates_from_pharmacological_phenomena
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Experiment #00000093

What is the core mechanism that Almased uses to improve metabolism and liver function and can the mechanism be repurposed as a therapeutic in neurodegenerative disease via the gut-brain axis?

Dietary Therapy _gates_from_dietary_therapy Intestinal Mucosa _gates_to_intestinal_mucosa _gates_from_intestinal_mucosa Inflammation Mediators _gates_to_inflammation_mediators Pro-inflammatory mediators _gates_from_pro_inflammatory_mediators Gastrointestinal Microbiome
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Experiment #00000084

SOD1 Research July 2026

Genetic Testing _gates_from_genetic_testing Drug Delivery Systems _gates_to_drug_delivery_systems _gates_from_drug_delivery_systems Superoxide Dismutase-1 _gates_to_superoxide_dismutase_1 Protein Aggregates _gates_from_protein_aggregates Oxidative Stress
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Experiment #00000083

Dietary strategy: High amylose maize starch may be identified as a non-invasive tool to improve outcomes in TBI, and potentially hypoxic neurovascular damage, suggesting it could be repurposed for high-altitude workers or elderly patients with cognitive frailty.

High Amylose Maize Starch (HAMS) _gates_from_high_amylose_maize_starch__hams_ Fatty Acids, Volatile _gates_to_fatty_acids__volatile _gates_from_fatty_acids__volatile Blood-Brain Barrier _gates_to_blood_brain_barrier _gates_from_blood_brain_barrier Brain Injuries, Traumatic _gates_to_brain_injuries__traumatic
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Experiment #00000066

Are there any wellness alternatives for Von Willebrand Disease?

von Willebrand Diseases _gates_from_von_willebrand_diseases Multidisciplinary Care _gates_to_multidisciplinary_care _gates_from_multidisciplinary_care Transcutaneous Electric Nerve Stimulation _gates_to_transcutaneous_electric_nerve_stimulation Electric Stimulation Therapy _gates_to_electric_stimulation_therapy _gates_from_electric_stimulation_therapy
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Experiment #00000054

What dietary habits are beneficial towards reducing excess/harmful tyramine in order to improve liver and gut health?

Dietary Proteins _gates_from_dietary_proteins Aromatic-L-Amino-Acid Decarboxylases _gates_to_aromatic_l_amino_acid_decarboxylases _gates_from_aromatic_l_amino_acid_decarboxylases Tyramine _gates_to_tyramine _gates_from_tyramine Gastrointestinal Diseases _gates_to_gastrointestinal_diseases
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Experiment #00000028

Are there any vitamins or supplements that have either old or recent clinical trial evidence of being beneficial for preventing or reducing migraines that may have been overlooked? I cannot afford the current migraine medications.

Dietary Factors _gates_from_dietary_factors Mitochondrial Dysfunction _gates_to_mitochondrial_dysfunction _gates_from_mitochondrial_dysfunction Hyperacusis _gates_to_hyperacusis Neurogenic Inflammation _gates_from_neurogenic_inflammation Dietary Supplements
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Experiment #00000027

How does eating legumes and vegetables help restore gut-brain axis homeostasis?

Vegetables _gates_from_vegetables Gastrointestinal Microbiome _gates_to_gastrointestinal_microbiome _gates_from_gastrointestinal_microbiome Inflammation _gates_to_inflammation _gates_from_inflammation Neuroprotection _gates_to_neuroprotection
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Experiment #00000019

What is the role of 3-indolepropionic acid within the body, and what foods or nutrients may help replenish it if deficient?

Edible Grain _gates_from_edible_grain Clostridium sporogenes _gates_to_clostridium_sporogenes Gastrointestinal Microbiome _gates_from_gastrointestinal_microbiome 3-indolepropionic acid _gates_to_3_indolepropionic_acid _gates_from_3_indolepropionic_acid Signal Transduction
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